Study protocol for Attachment & Child Health (ATTACHTM) program: promoting vulnerable Children's health at scale

Lubna Anis, Nicole Letourneau, Kharah M Ross, Martha Hart, Ian Graham, Simone Lalonde, Suzanna Varro, Alanna Baldwin, Angela Soulsby, Annette Majnemer, Carlene Donnelly, Caroline Piotrowski, Carrie Collier, Cliff Lindeman, Dan Goldowitz, Dawn Isaac, Denise Thomson, Diane Serré, Elisabeth Citro, Gabrielle Zimmermann, Harold Pliszka, Jackie Mann, Janine Baumann, Joanna Piekarski, Jo-Anne Dalton, Joy Johnson-Green, Karen Wood, Marcia Bruce, Maria Santana, Matt Mayer, Meghan Gould, Michael Kobor, Michelle Flowers, Michelle Haywood, Michelle Koerner, Nancy Parker, Nazeem Muhajarine, Paul Fairie, Rabea Chrishti, Robert Perry, Sarah Merrill, Shellie Pociuk, StephanieTaylor, Steve Cole, Tim Murphy, Tmira Marchment, Virginia Xavier, Zahra Shajani, Zoe West, Lubna Anis, Nicole Letourneau, Kharah M Ross, Martha Hart, Ian Graham, Simone Lalonde, Suzanna Varro, Alanna Baldwin, Angela Soulsby, Annette Majnemer, Carlene Donnelly, Caroline Piotrowski, Carrie Collier, Cliff Lindeman, Dan Goldowitz, Dawn Isaac, Denise Thomson, Diane Serré, Elisabeth Citro, Gabrielle Zimmermann, Harold Pliszka, Jackie Mann, Janine Baumann, Joanna Piekarski, Jo-Anne Dalton, Joy Johnson-Green, Karen Wood, Marcia Bruce, Maria Santana, Matt Mayer, Meghan Gould, Michael Kobor, Michelle Flowers, Michelle Haywood, Michelle Koerner, Nancy Parker, Nazeem Muhajarine, Paul Fairie, Rabea Chrishti, Robert Perry, Sarah Merrill, Shellie Pociuk, StephanieTaylor, Steve Cole, Tim Murphy, Tmira Marchment, Virginia Xavier, Zahra Shajani, Zoe West

Abstract

Background: Children's exposure to toxic stress (e.g., parental depression, violence, poverty) predicts developmental and physical health problems resulting in health care system burden. Supporting parents to develop parenting skills can buffer the effects of toxic stress, leading to healthier outcomes for those children. Parenting interventions that focus on promoting parental reflective function (RF), i.e., parents' capacity for insight into their child's and their own thoughts, feelings, and mental states, may understand help reduce societal health inequities stemming from childhood stress exposures. The Attachment and Child Health (ATTACHTM) program has been implemented and tested in seven rapid-cycling pilot studies (n = 64) and found to significantly improve parents' RF in the domains of attachment, parenting quality, immune function, and children's cognitive and motor development. The purpose of the study is to conduct an effectiveness-implementation hybrid (EIH) Type II study of ATTACHTM to assess its impacts in naturalistic, real-world settings delivered by community agencies rather than researchers under more controlled conditions.

Methods: The study is comprised of a quantitative pre/post-test quasi-experimental evaluation of the ATTACHTM program, and a qualitative examination of implementation feasibility using thematic analysis via Normalization Process Theory (NPT). We will work with 100 families and their children (birth to 36-months-old). Study outcomes include: the Parent Child Interaction Teaching Scale to assess parent-child interaction; the Parental Reflective Function and Reflective Function Questionnaires to assess RF; and the Ages and Stages Questionnaire - 3rd edition to examine child development, all administered pre-, post-, and 3-month-delayed post-assessment. Blood samples will be collected pre- and post- assessment to assess immune biomarkers. Further, we will conduct one-on-one interviews with study participants, health and social service providers, and administrators (total n = 60) from each collaborating agency, using NPT to explore perceptions and experiences of intervention uptake, the fidelity assessment tool and e-learning training as well as the benefits, barriers, and challenges to ATTACHTM implementation.

Discussion: The proposed study will assess effectiveness and implementation to help understand the delivery of ATTACHTM in community agencies.

Trial registration: Name of registry: https://clinicaltrials.gov/.

Registration number: NCT04853888 . Date of registration: April 22, 2021.

Keywords: ATTACHTM; Child development; EIH type 2 clinical trial; Normalization process theory; Parent-child interaction; Parenting program; Quasi-experimental design; Reflective function; Study protocol.

Conflict of interest statement

The authors have no competing interests to report.

© 2022. The Author(s).

Figures

Fig. 1
Fig. 1
The Schedule of Enrolment, Intervention, and Assessment

References

    1. Brent DA, Silverstein M. Shedding light on the long shadow of childhood adversity. JAMA. 2013;309(17):1777–1778. doi: 10.1001/jama.2013.4220.
    1. Cuijpers P, Smit F, Unger F, Stikkelbroek Y, ten Have M, de Graaf R. The disease burden of childhood adversities in adults: a population-based study. Child Abuse Negl. 2011;35(11):937–945. doi: 10.1016/j.chiabu.2011.06.005.
    1. Francis L, DePriest K, Wilson M, Gross D. Child poverty, toxic stress, and social determinants of health: screening and care coordination. Online J Issues Nurs. 2018;23(3). .
    1. Gershoff ET. Should parents' physical punishment of children be considered a source of toxic stress that affects brain development? Fam Relat. 2016;65(1):151–162. doi: 10.1111/fare.12177.
    1. Center on the Developing Child at Harvard University . The foundations of lifelong health are built in early childhood. Boston: Harvard University; 2010.
    1. Van Doesum KT, Riksen-Walraven JM, Hosman CM, Hoefnagels C. A randomized controlled trial of a home-visiting intervention aimed at preventing relationship problems in depressed mothers and their infants. Child Dev. 2008;79(3):547–561. doi: 10.1111/j.1467-8624.2008.01142.x.
    1. Yoshikawa H, Aber JL, Beardslee WR. The effects of poverty on the mental, emotional, and behavioral health of children and youth: implications for prevention. Am Psychol. 2012;67(4):272. doi: 10.1037/a0028015.
    1. Chiesa M, Fonagy P. Reflective function as a mediator between childhood adversity, personality disorder and symptom distress. Personal Ment Health. 2014;8(1):52–66. doi: 10.1002/pmh.1245.
    1. Anis L, Letourneau N, Benzies K, Ewashen C, Hart MJ. Effect of the attachment and child health parent training program on parent–child interaction quality and child development. Can J Nurs Res. 2020;52(2):157–68. .
    1. Letourneau N, Anis L, Ntanda H, Novick J, Steele M, Steele H, Hart M. Attachment & Child Health (ATTACH) pilot trials: Effect of parental reflective function intervention for families affected by toxic stress. Infant mental health journal. 2020;41(4):445–62. .
    1. Letourneau N, Tryphonopoulos P, Giesbrecht G, Dennis CL, Bhogal S, Watson B. Narrative and meta-analytic review of interventions aiming to improve maternal-child attachment security. Infant Ment Health J. 2015;36(4):366–387. doi: 10.1002/imhj.21525.
    1. Bergman K, Sarkar P, Glover V, O'Connor TG. Maternal prenatal cortisol and infant cognitive development: moderation by infant–mother attachment. Biol Psychiatry. 2010;67(11):1026–1032. doi: 10.1016/j.biopsych.2010.01.002.
    1. van IJzendoorn M, Dijkstra J, Bus A. Attachment, intelligence and language: a meta-analysis. Soc Dev. 1995;4(2):115–128. doi: 10.1111/j.1467-9507.1995.tb00055.x.
    1. Madigan S, Atkinson L, Laurin K, Benoit D. Attachment and internalizing behavior in early childhood: a meta-analysis. Dev Psychol. 2013;49(4):672–683. doi: 10.1037/a0028793.
    1. Puig J, Englund M, Simpson J, Collins W. Predicting adult physical illness from infant attachment: a prospective longitudinal study. Health Psychol. 2013;32(4):409–417. doi: 10.1037/a0028889.
    1. Anis L, Benzies KM, Ewashen C, Hart MJ, Letourneau N. Fidelity assessment checklist development for community nursing research in early childhood. Front Public Health. 2021;9:496. doi: 10.3389/fpubh.2021.582950.
    1. Perrin JM, Lu MC, Geller A, DeVoe JE. Vibrant and healthy kids: Aligning science, practice, and policy to advance health equity. Acad Pediatr. 2020;20(2):160–2. .
    1. CENTER OF THE DEVELOPING CHILD at Harvard University. From Best Practices to Breakthrough Impacts: A Science-Based Approach to Building a More Promising Future for Young Children and Families. Cambridge: Harvard University; 2016.
    1. Shonkoff J, Richmond J, Levitt P, Bunge S, Cameron J, Duncan G, et al. From best practices to breakthrough impacts a science-based approach to building a more promising future for young children and families. Cambirdge: Harvard University, Center on the Developing Child; 2016.
    1. Ross KM, Cole S, Sanghera H, Anis L, Hart M, Letourneau N. The ATTACHTM program and immune cell gene expression profiles in mothers and children: A pilot randomized controlled trial. Brain, behavior, & immunity-health. 2021;18:100358. .
    1. Anis L, Ross K, Ntanda H, Hart M, Letourneau N. Effect of the ATTACHTM on parent-child attachment and parental Reflective Function and parental depression scores. Int J Environ Res Public Health. 2022;19(14):8425. 10.3390/ijerph19148425.
    1. Miller G, Brody G, Yu T, E. C. A family-oriented psychosocial intervention reduces inflammation in low-SES American youth. PNAS. 2014;111(31):11287–11292. doi: 10.1073/pnas.1406578111.
    1. Stress T. Center on the Developing Child at Harvard University. Center on the Developing Child (). 2018.
    1. Jones M, Moore S, Kobor M. Principles and challenges of applying epigenetic epidemiology to psychology. Jones, MJ, Moore, SR, Kobor, MS. 2018. .
    1. Jull J, Giles A, Graham ID. Community-based participatory research and integrated knowledge translation: advancing the co-creation of knowledge. Implement Sci. 2017;12(1):1–9. doi: 10.1186/s13012-017-0696-3.
    1. CIHR/SPOR . Strategy for patient-oriented research: patient engagement framework. Ottawa: CIHR/SPOR; 2014.
    1. Graham ID, Kothari A, McCutcheon C. Moving knowledge into action for more effective practice, programmes and policy: protocol for a research programme on integrated knowledge translation. Implement Sci. 2018;13(1):22. doi: 10.1186/s13012-017-0700-y.
    1. Vandall-Walker V, Lead PE, Mason-Lai P, Goodman A, Hegadoren K, Pringle P, Wasylak T. www. aihealthsolutions. ca/initiatives-partnerships/spor/The views and opinions expressed in this report are those of the authors and do not necessarily reflect those of Alberta SPOR SUPPORT Unit's funding, or partnering organizations. .
    1. Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012;50(3):217. doi: 10.1097/MLR.0b013e3182408812.
    1. Education A. How are our young children doing. Final report of the early child development mapping project (ECMap). 2014. .
    1. Letourneau N, Dennis C, Benzies K, Duffett-Leger L, Stewart M, Tryphonopoulos P, et al. Postpartum depression is a family affair: addressing the impact on mothers, fathers, and children. Issues Mental Health Nurs. 2012;33(7):445–457. doi: 10.3109/01612840.2012.673054.
    1. Letourneau NL, Dennis CL, Cosic N, Linder J. The effect of perinatal depression treatment for mothers on parenting and child development: A systematic review. Depress Anxiety. 2017;34(10):928–66. .
    1. Abdollahi F, Abhari FR, Zarghami M. Post-partum depression effect on child health and development. Acta Medica Iranica. 2017:109–14. .
    1. Valla L, Wentzel-Larsen T, Smith L, Birkeland MS, Slinning K. Association between maternal postnatal depressive symptoms and infants’ communication skills: a longitudinal study. Infant Behav Dev. 2016;45:83–90. doi: 10.1016/j.infbeh.2016.10.001.
    1. Tuovinen S, Lahti-Pulkkinen M, Girchenko P, Lipsanen J, Lahti J, Heinonen K, et al. Maternal depressive symptoms during and after pregnancy and child developmental milestones. Depress Anxiety. 2018;35(8):732–741. doi: 10.1002/da.22756.
    1. Vameghi R, Akbari SAA, Sajedi F, Sajjadi H, Alavi H. Path analysis association between domestic violence, anxiety, depression and perceived stress in mothers and children’s development. Iranian J Child Neurol. 2016;10(4):36.
    1. Letourneau N, Young Morris C, Secco L, Stewart M, Hughes J, Critchley K. Mothers and infants exposed to intimate partner violence compensate. Violence Vict. 2013;28(4):571–586. doi: 10.1891/0886-6708.VV-D-12-00077.
    1. Wei Q, Zhang J, Scherpbier R, Zhao C, Luo S, Wang X, et al. High prevalence of developmental delay among children under three years of age in poverty-stricken areas of China. Public Health. 2015;129(12):1610–1617. doi: 10.1016/j.puhe.2015.07.036.
    1. Potijk MR, Kerstjens JM, Bos AF, Reijneveld SA, de Winter AF. Developmental delay in moderately preterm-born children with low socioeconomic status: risks multiply. J Pediatr. 2013;163(5):1289–1295. doi: 10.1016/j.jpeds.2013.07.001.
    1. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R. Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci. 2007;104(4):1319–1324. doi: 10.1073/pnas.0610362104.
    1. Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB. Cumulative childhood stress and autoimmune diseases in adults. Psychosom Med. 2009;71(2):243. doi: 10.1097/PSY.0b013e3181907888.
    1. Danese A, Moffitt TE, Harrington H, Milne BJ, Polanczyk G, Pariante CM, et al. Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med. 2009;163(12):1135–1143. doi: 10.1001/archpediatrics.2009.214.
    1. Rasmussen LJH, Moffitt TE, Eugen-Olsen J, Belsky DW, Danese A, Harrington H, et al. Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood. J Child Psychol Psychiatry. 2019;60(2):199–208. doi: 10.1111/jcpp.12928.
    1. Johnson SB, Riley AW, Granger DA, Riis J. The science of early life toxic stress for pediatric practice and advocacy. Pediatrics. 2013;131(2):319–327. doi: 10.1542/peds.2012-0469.
    1. Hantsoo L, Kornfield S, Anguera MC, Epperson CN. Inflammation: a proposed intermediary between maternal stress and offspring neuropsychiatric risk. Biol Psychiatry. 2019;85(2):97–106. doi: 10.1016/j.biopsych.2018.08.018.
    1. Shonkoff JP. Leveraging the biology of adversity to address the roots of disparities in health and development. Proc Natl Acad Sci. 2012;109(Supplement 2):17302–17307. doi: 10.1073/pnas.1121259109.
    1. Levendosky AA, Bogat GA, Bernard N, Garcia A. The effects of intimate partner violence on the early caregiving system. Motherhood in the face of trauma: Springer; 2018. p. 39–54.
    1. De Falco S, Emer A, Martini L, Rigo P, Pruner S, Venuti P. Predictors of mother–child interaction quality and child attachment security in at-risk families. Front Psychol. 2014;5:898. doi: 10.3389/fpsyg.2014.00898.
    1. Mesman J, van IJzendoorn MH, Bakermans-Kranenburg MJ. Unequal in opportunity, equal in process: parental sensitivity promotes positive child development in ethnic minority families. Child Dev Perspect. 2012;6(3):239–250. doi: 10.1111/j.1750-8606.2011.00223.x.
    1. Letourneau N, Hungler K, Fisher K. Comparing parent-child interactions of poor Aboriginal and non-Aboriginal people. Child Care Health Dev. 2005;31(5):545–554. doi: 10.1111/j.1365-2214.2005.00549.x.
    1. Suchman NE, DeCoste CL. Substance abuse and addiction: implications for early relationships and interventions. Zero Three. 2018;38(5):17.
    1. Forman DR, O'Hara MW, Stuart S, Gorman LL, Larsen KE, Coy KC. Effective treatment for postpartum depression is not sufficient to improve the developing mother-child relationship. Dev Psychopathol. 2007;19(2):585–602. doi: 10.1017/S0954579407070289.
    1. Suchman N, DeCoste C, Rosenberger P, McMahon T. Attachment-based intervention for substance-using mothers: a preliminary test of the proposed mechanisms of change. Infant Ment Health J. 2012;33(4):360–371. doi: 10.1002/imhj.21311.
    1. Ainsworth M, Blehar M, Waters B, Wall S. Patterns of attachment: a psychological study of the strange situation. Hillsdale: Lawrence Erlbaum Associates; 1978.
    1. Bowlby J. A secure base: parent-child attachment and healthy development. New York: Basic Books; 1988.
    1. Svanberg P, Mennet L, Spieker S. Promoting a secure attachment: a primary prevention practice model. Clin Child Psychol Psych. 2010;15(3):363–378. doi: 10.1177/1359104510367584.
    1. Crittenden P. A dynamic-maturational model of attachment. J Fam Ther. 2006;27(2):105–115. doi: 10.3917/tf.062.0105.
    1. West K, Matthews B, Kerns K. Mother-child attachment and cognitive perfromance in middle childhood: an examination of mediating mechanisms. Early Child Res Q. 2013;28(2):259–270. doi: 10.1016/j.ecresq.2012.07.005.
    1. Mikulincer M, Shaver PR, Pereg D. Attachment theory and affect regulation: the dynamics, development, and cognitive consequences of attachment-related strategies. Motiv Emot. 2003;27(2):77–102. doi: 10.1023/A:1024515519160.
    1. Pietromonaco PR, Powers SI. Attachment and health-related physiological stress processes. Curr Opin Psychol. 2015;1:34–39. doi: 10.1016/j.copsyc.2014.12.001.
    1. Letourneau NL, Kozyrskyj AL, Cosic N, Ntanda HN, Anis L, Hart MJ, et al. Maternal sensitivity and social support protect against childhood atopic dermatitis. Allergy, Asthma Clin Immunol. 2017;13(1):26. doi: 10.1186/s13223-017-0199-4.
    1. Steele H, Steele M. On the origns of reflective functionning. In: Busch F, editor. Mentalization: theoretical considerations, research findings, and clincal implications. Psychoanalytic inquiry book series. NY: Analytic Books; 2008. pp. 133–158.
    1. Fonagy P, Target M. Attachment and reflective function: their role in self-organization. Dev Psychopathol. 1997;9(4):679–700. doi: 10.1017/S0954579497001399.
    1. Slade A. Parental reflective function: an introduction. Attach Hum Dev. 2005;7(3):269–281. doi: 10.1080/14616730500245906.
    1. Slade A, Grienenberger J, Bernbach E, Levy D, Locker A. Maternal reflective functioning, attachment, and the transmission gap: a preliminary study. Attach Hum Dev. 2005;7(3):283–298. doi: 10.1080/14616730500245880.
    1. Savov S, Atanassov N. Deficits of affect mentalization in patients with drug addiction: Theoretical and clinical aspects. International Scholarly Research Notices. 2013;2013. .
    1. Asen E, Fonagy P. Mentalization-based family therapy. In: Fonagy ABP, editor. Handbood of mentalizing in mental health practice. London: American Psychiatric Publishing Inc.; 2012. pp. 107–128.
    1. Fischer-Kern M, Fonagy P, Kapusta ND, Luyten P, Boss S, Naderer A, et al. Mentalizing in female inpatients with major depressive disorder. J Nerv Ment Dis. 2013;201(3):202–207. doi: 10.1097/NMD.0b013e3182845c0a.
    1. Lyons-Ruth K. Dissociation and the parent–infant dialogue: a longitudinal perspective from attachment research. Attachment. 2015;9(3):253–276.
    1. Madigan S, Moran G, Schuengel C, Pederson DR, Otten R. Unresolved maternal attachment representations, disrupted maternal behavior and disorganized attachment in infancy: links to toddler behavior problems. J Child Psychol Psychiatry. 2007;48(10):1042–1050. doi: 10.1111/j.1469-7610.2007.01805.x.
    1. Midgely N, Vrouva I, editors. Mentalization-based interventions with children, young people and their families. New York: Routledge; 2012.
    1. Yaholkoski A, Hurl K, Theule J. Efficacy of the circle of security intervention: a meta-analysis. J Infant Child Adoles Psychother. 2016;15(2):95–103. doi: 10.1080/15289168.2016.1163161.
    1. Fonagy P. Thinking about thinking: some clinical and theoretical considerations in the treatmetn of a borderline patient. Int J Pscyho-Anal. 1991;72:1–18.
    1. Brody G, Yu T, Chen E, Beach S, Miller G. Family-centred prevention ameliorates the longitudinal association between risky family process and epigenetic aging. J Child Psychol Psychiatry. 2016;57(5):566–574. doi: 10.1111/jcpp.12495.
    1. May CR, Cummings A, Girling M, Bracher M, Mair FS, May CM, et al. Using normalization process theory in feasibility studies and process evaluations of complex healthcare interventions: a systematic review. Implement Sci. 2018;13(1):80. doi: 10.1186/s13012-018-0758-1.
    1. May CR, Mair F, Finch T, MacFarlane A, Dowrick C, Treweek S, et al. Development of a theory of implementation and integration: normalization process theory. Implement Sci. 2009;4(1):29. doi: 10.1186/1748-5908-4-29.
    1. May C, Finch T, Mair F, Ballini L, Dowrick C, Eccles M, et al. Understanding the implementation of complex interventions in health care: the normalization process model. BMC Health Serv Res. 2007;7(1):148. doi: 10.1186/1472-6963-7-148.
    1. Murray E, Treweek S, Pope C, MacFarlane A, Ballini L, Dowrick C, et al. Normalisation process theory: a framework for developing, evaluating and implementing complex interventions. BMC Med. 2010;8(1):63. doi: 10.1186/1741-7015-8-63.
    1. McEvoy R, Ballini L, Maltoni S, O’Donnell CA, Mair FS, MacFarlane A. A qualitative systematic review of studies using the normalization process theory to research implementation processes. Implement Sci. 2014;9(1):2. doi: 10.1186/1748-5908-9-2.
    1. Rutherford HJ, Booth CR, Luyten P, Bridgett DJ, Mayes LC. Investigating the association between parental reflective functioning and distress tolerance in motherhood. Infant Behav Dev. 2015;40:54–63. doi: 10.1016/j.infbeh.2015.04.005.
    1. Oxford M, Finlay D. NCAST caregiver/parent child interaction teaching manual. 2. Seattle: NCAST Programs; 2013.
    1. Anis L, Perez G, Benzies KM, Ewashen C, Hart M, Letourneau N. Convergent validity of three measures of reflective function: Parent development interview, parental reflective function questionnaire, and reflective function questionnaire. Front Psychol. 2020;11:574719. .
    1. Fonagy P, Luyten P, Moulton-Perkins A, Lee Y-W, Warren F, Howard S, et al. Development and validation of a self-report measure of mentalizing: the reflective functioning questionnaire. PLoS One. 2016;11(7):e0158678. doi: 10.1371/journal.pone.0158678.
    1. Bricker D, Squires J. Ages and stages Questionnaire-3. 3. Baltimore: Brookes Publishing; 2009.
    1. Mackrides PS, Ryherd SJ. Screening for developmental delay. American family physician. 2011;84(5):544–9. .
    1. Lamsal R, Dutton DJ, Zwicker JD. Using the ages and stages questionnaire in the general population as a measure for identifying children not at risk of a neurodevelopmental disorder. BMC Pediatr. 2018;18(1):122. doi: 10.1186/s12887-018-1105-z.
    1. McDade TW, M. Ross K, L. Fried R, Arevalo JM, Ma J, Miller GE, et al. Genome-wide profiling of RNA from dried blood spots: convergence with bioinformatic results derived from whole venous blood and peripheral blood mononuclear cells. Biodemogr Soc Biol. 2016;62(2):182–197. doi: 10.1080/19485565.2016.1185600.
    1. Walker RM, MacGillivray L, McCafferty S, Wrobel N, Murphy L, Kerr SM, Morris SW, Campbell A, McIntosh AM, Porteous DJ, Evans KL. Assessment of dried blood spots for DNA methylation profiling. Wellcome Open Research. 2019;4. .
    1. Pillai Riddell RR, Racine NM, Turcotte K, Uman LS, Horton RE, Din Osmun L, et al. Cochrane review: non-pharmacological management of infant and young child procedural pain. Evid-Based Child Health Cochr Rev J. 2012;7(6):1905–2121. doi: 10.1002/ebch.1883.
    1. Johnson JL, Greaves L, Repta R. Better science with sex and gender: facilitating the use of a sex and gender-based analysis in health research. Int J Equity Health. 2009;8(1):1–11. doi: 10.1186/1475-9276-8-14.
    1. Joffe H. Thematic analysis. Qualitative research methods in mental health and psychotherapy. 2012. p. 1.
    1. Patton M. Qualitative research and evaluation methods. 3. Thousand Oaks: Sage; 2002.
    1. Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression: development of the 10-item Edinburgh postnatal depression scale. Br J Psychiatry. 1987;150:782–786. doi: 10.1192/bjp.150.6.782.
    1. Matthey S, Henshaw C, Elliott S, Barnett B. Variability in use of cut-off scores and formats on the Edinburgh postnatal depression scale–implications for clinical and research practice. Arch Women's Mental Health. 2006;9(6):309–315. doi: 10.1007/s00737-006-0152-x.
    1. Straus MA, Douglas EM. A short form of the revised conflict tactics scales, and typologies for severity and mutuality. Violence Vict. 2004;19(5):507–520. doi: 10.1891/vivi.19.5.507.63686.
    1. WHO ASSIST Working Group The alcohol, smoking and substance involvement screening test (ASSIST): development, reliability and feasibility. Addiction. 2002;97(9):1183–1194. doi: 10.1046/j.1360-0443.2002.00185.x.
    1. Humeniuk R, Ali R, Babor TF, Farrell M, Formigoni ML, Jittiwutikarn J, et al. Validation of the alcohol, smoking and substance involvement screening test (ASSIST) Addiction. 2008;103(6):1039–1047. doi: 10.1111/j.1360-0443.2007.02114.x.
    1. Felitti V, Anda RF. The relationship of adverse childhood experiences to adult medical disease, psychiatric disorders, and sexual behavior: implications for health care. In: R. Lanius EV, editor. The hidden epidemic: the impact of early life trauma on health and disease. Cambridge: Cambridge University Press; 2009.
    1. Smith BW, Dalen J, Wiggins K, Tooley E, Christopher P, Bernard J. The brief resilience scale: assessing the ability to bounce back. Int J Behavioral Med. 2008;15(3):194–200. doi: 10.1080/10705500802222972.
    1. Terry G, Hayfield N, Clarke V, Braun V. Thematic analysis. The sage handbook of qualitative research in psychology. 2017. pp. 17–37.
    1. Richards L. Handling qualitative data: a practical guide. London: Sage; 2005.
    1. Ordway MR, Webb D, Sadler LS, Slade A. Parental reflective functioning: an approach to enhancing parent-child relationships in pediatric primary care. J Pediatr Health Care. 2015;29(4):325–34. .
    1. Center on the Developing Child . The Frontiers of innovation translational science model: a promising new approach for innovation in program develoment in program development and evaluation. Cambridge: MA Harvard University; 2016.
    1. Cowan PA, Cowan CP, Pruett MK, Pruett K, Wong JJ. Promoting fathers' engagement with children: preventive interventions for low-income families. J Marriage Fam. 2009;71(3):663–679. doi: 10.1111/j.1741-3737.2009.00625.x.
    1. Kochanska G, Kim S. Early attachment organization with both parents and future behavior problems: from infancy to middle childhood. Child Dev. 2013;84(1):283–296. doi: 10.1111/j.1467-8624.2012.01852.x.

Source: PubMed

Подписаться