Appropriateness of colonoscopy requests according to EPAGE-II in the Spanish region of Catalonia

M Marzo-Castillejo, J Almeda, J J Mascort, O Cunillera, R Saladich, R Nieto, P Piñeiro, M Llagostera, Fx Cantero, M Segarra, D Puente, M Marzo-Castillejo, J Almeda, J J Mascort, O Cunillera, R Saladich, R Nieto, P Piñeiro, M Llagostera, Fx Cantero, M Segarra, D Puente

Abstract

Background: In a context of increasing demand and pressure on the public health expenditure, appropriateness of colonoscopy indications is a topic of discussion. The objective of this study is to evaluate the appropriateness of colonoscopy requests performed in a primary care (PC) setting in Catalonia.

Methods: Cross-sectional descriptive study. Out-patients >14 years of age, referred by their reference physicians from PC or hospital care settings to the endoscopy units in their reference hospitals, to undergo a colonoscopy. Evaluation of the appropriateness of 1440 colonoscopy requests issued from January to July 2011, according to the EPAGE-II guidelines (European Panel on the Appropriateness of Gastrointestinal Endoscopy).

Results: The most frequent indications of diagnostic suspicion requests were: rectal bleeding (37.46 %), abdominal pain (26.54 %), and anaemia study (16.78 %). The most frequent indications of disease follow-up were adenomas (58.1 %), and CRC (31.16 %). Colonoscopy was appropriate in 73.68 % of the cases, uncertain in 16.57 %, and inappropriate in 9.74 %. In multivariate analysis, performed colonoscopies reached an OR of 9.9 (CI 95 % 1.16-84.08) for qualifying as appropriate for colorectal cancer (CRC) diagnosis, 1.49 (CI 95 % 1.1-2.02) when requested by a general practitioner, and 1.09 (CI 95 % 1.07-1.1) when performed on women.

Conclusions: Appropriateness of colonoscopy requests in our setting shows a suitable situation in accordance with recognized standards. General practitioners contribute positively to this appropriateness level. It is necessary to provide physicians with simple and updated guidelines, which stress recommendations for avoiding colonoscopy requests in the most prevalent conditions in PC.

References

    1. Atkin WS, Valori R, Kuipers EJ, Hoff G, Senore C, Segnan N, et al. European guidelines for quality assurance in colorectal cancer screening and diagnosis. First edition colonoscopic surveillance following adenoma removal. Endoscopy. 2012;44:SE151–63. doi: 10.1055/s-0031-1291643.
    1. Shaukat A, Mongin SJ, Geisser MS, Lederle FA, Bond JH, Mandel JS, et al. Long-term mortality after screening for colorectal cancer. N Engl J Med. 2013;369:1106–14. doi: 10.1056/NEJMoa1300720.
    1. Nishihara R, Wu K, Lochhead P, Morikawa T, Liao X, Qian ZR. Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med. 2013;369:1095–105. doi: 10.1056/NEJMoa1301969.
    1. Grupo de trabajo de la guía de práctica clínica sobre prevención cáncer colorectal. Guía de práctica clínica. Actualización 2009. Barcelona. Asociación Española de Gastroenterología, Sociedad Española de Medicina de Familia y Centro Cochrane Iberoamericano; 2009. Programa de guías de práctica clínica en enfermedades digestivas, desde la atención primaria a la especializada: 4.
    1. Globocan 2012. Cancer Incidence and Mortality Worldwide in 2012. [last accessed 30/03/2014]. Avalaible at:
    1. De Angelis R, Sant M, Coleman MP, Francisci S, Baili P, Pierannunzio D, et al. EUROCARE-5 Working Group. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE 5- a population-based study. Lancet Oncol. 2014;15:23–34. doi: 10.1016/S1470-2045(13)70546-1.
    1. Winawer SJ, NPS investigators The achievements, impact, and future of the national polyps study. Gastrointest Endosc. 2006;64:975–8. doi: 10.1016/j.gie.2006.08.039.
    1. Zauber AG, Winawer SJ, O’Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, et al. Colonoscopic polypectomy and long-term prevention colorectal-cancer deaths. N Engl J Med. 2012;366:687–96. doi: 10.1056/NEJMoa1100370.
    1. Rapuri S, Spencer J, Eckels D. Importance of postpolypectomy surveillance and postpolypectomy compliance to follow-up screening – review of literature. Int J Colorectal Dis. 2008;23:453–9. doi: 10.1007/s00384-007-0430-8.
    1. Schreuders E, Sint Nicolaas J, de Jonge V, van Kooten H, Soo I, Sadowski D, et al. The appropriateness of surveillance colonoscopy intervals after polypectomy. Can J Gastroenterol. 2013;27:33–8.
    1. Grupo de trabajo de la guía de práctica clínica sobre el manejo del paciente con rectorragia. Guía de práctica clínica. Actualización 2007. Barcelona. Asociación Española de Gastroenterología, Sociedad Española de Medicina de Familia y Centro Cochrane Iberoamericano; 2007. Programa de guías de práctica clínica en enfermedades digestivas, desde la atención primaria a la especializada: 2.
    1. Jover R, Herraiz M, Alarcon O, Brullet E, Bujanda L, Bustamante M, et al. Clinical practice guidelines: quality of colonoscopy in colorectal cancer screening. Endoscopy. 2012;44:444–51. doi: 10.1055/s-0032-1306690.
    1. Lee RH. Quality colonoscopy: a matter of time, technique or technology? World J Gastroenterology. 2013;19:1517–22. doi: 10.3748/wjg.v19.i10.1517.
    1. European Panel on the Appropriateness of Gastrointestinal endoscopy II. Institute for Social and Preventive Medecine - Division of gastroenterology & Hepatology. Copyright (©) 2008 IUMSP / CHUV, Lausanne, Switzerland Disponible en: . Last update: 04.06.2008.
    1. Early DS, Ben-Menachem T, Decker GA, Evans JA, Fanelli RD, Fisher DA, et al. ASGE. Standards of practice committee. Appropriate use of GI endoscopy. Gastrointest Endosc. 2012;75:1127–31. doi: 10.1016/j.gie.2012.01.011.
    1. Puente D, Cantero FX, Llagostera M, Piñeiro P, Nieto R, Saladich R, et al. The CANCER-REAP research group. A cross-sectional study of the appropriateness of colonoscopy requests in the spanish region of Catalonia. BMJ Open. 2012;2:e002207. doi: 10.1136/bmjopen-2012-002207.
    1. Fleiss JL. The design and analysis of clinical experiments. New York: John Wiley Sons; 1986. pp. 1–31.
    1. Burnand B, Kernan WN, Feinstein AR. Indexes and boundaries for “quantitative significance” in statistical decisions. J Clin Epidemiol. 1990;43:1273–84. doi: 10.1016/0895-4356(90)90093-5.
    1. España. Ley Orgánica 15/1999, de 13 de diciembre, de Protección de Datos de Carácter Personal. Boletín Oficial del Estado (BOE), 14 de diciembre de 1999, núm. 298, p. 43088–43099. [last accessed 05/10/2015]. Avalaible at: .
    1. Hassan C, Di Giulio E, Marmo R, Zullo A, Annibale B. Appropriateness of the indication for colonoscopy: systematic review and meta-analysis. J Gastrointestin Liver Dis. 2011;20:279–286.
    1. Harris JK, Froehlich F, Gonvers JJ, Wietlisbach V, Burnand B, Vader JP. The appropriateness of colonoscopy: a multi-center, international, observational study. Int J Qual Health Care. 2007;19:150–157. doi: 10.1093/intqhc/mzm008.
    1. Terraz O, Wietlisbach V, Jeannot JG, Burnanda B, Froehlich F, Gonvers JJ, et al. The EPAGE internet guideline as a decision support tool for determining the appropriateness of colonoscopy. Digestion. 2005;71:72–77. doi: 10.1159/000084522.
    1. Burnand B, Harris JK, Wietlisbach V, Froehlich F, Vader JP, Gonvers JJ. Use, appropriateness, and diagnostic yield of screening colonoscopy: an international observational study (EPAGE) Gastrointest Endosc. 2006;63:1018–1026. doi: 10.1016/j.gie.2006.01.051.
    1. de Bosset V, Froehlich F, Rey JP, Thorens J, Schneider C, Wietlisbach V, et al. Do explicit appropriateness criteria enhance the diagnostic yield of colonoscopy? Endoscopy. 2002;34:360–368. doi: 10.1055/s-2002-25277.
    1. Gonvers JJ, Harris JK, Wietlisbach V, et al. A European view of diagnostic yield and appropriateness of colonoscopy. Hepatogastroenterology. 2007;54:729–735.
    1. Balaguer F, Llach J, Castells A, Bordas JM, Pellisé M, Rodriguez-Moranta F, et al. The European panel on the appropriateness of gastrointestinal endoscopy guidelines colonoscopy in an open-access endoscopy unit: a prospective study. Aliment Pharmacol Ther. 2005;21:609–613. doi: 10.1111/j.1365-2036.2005.02359.x.
    1. Fernández-Esparrach G, Gimeno-García AZ, Llach J, Pellisé M, Ginès A, Balaguer F, et al. Recomendaciones de utilización de la endoscopia: análisis de la probabilidad de encontrar lesiones significativas en los pacientes procedentes de la atención extrahospitalaria. Med Clin (Barc) 2007;129:205–8. doi: 10.1157/13107917.
    1. Argüello L, Pertejo V, Ponce M, Peiró S, Garrigues V, Ponce J. The appropriateness of colonoscopies at a teaching hospital: magnitude, associated factors, and comparison of EPAGE and EPAGE-II criteria. Gastrointest Endosc. 2012;75:138–45. doi: 10.1016/j.gie.2011.08.039.
    1. Carrión S, Marín I, Lorenzo-Zuñiga V, Moreno-De Vega V, Boixa J. Adecuación de la indicación de la colonoscopia según los nuevos criterios de EPAGE II. Gastroenterol Hepatol. 2010;33:484–489. doi: 10.1016/j.gastrohep.2010.05.003.
    1. Gimeno García AZ, Gonzalez Y, Quintero E, Nicolas-Perez D, Adrian ZR, Romero R, et al. Clinical validation of the european panel on the appropriateness of gastrointestinal endoscopy (EPAGE) II criteria in an open-access unit: a prospective study. Endoscopy. 2012;44:32–37. doi: 10.1055/s-0031-1291386.
    1. Telford JJT. Inappropriate uses of colonoscopy. Advances in endoscopy. Current developments in diagnostic and therapeutic endoscopy. Gastroenterol Hepatol. 2012;8:343–4.
    1. Eskeland SL, Dalén E, Sponheim J, Lind E, Brunborg C, de Lange T. European panel on the appropriateness of gastrointestinal endoscopy II guidelines help in selecting and prioritizing patients referred to colonoscopy--a quality control study. Scand J Gastroenterol. 2014;49:492–500. doi: 10.3109/00365521.2014.886715.
    1. Hassan C, Quintero E, Dumonceau JM, Regula J, Brandão C, Chaussade S, et al. Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2013;45:842–851. doi: 10.1055/s-0033-1344548.

Source: PubMed

Подписаться