Emerging roles of non-coding RNAs in scoliosis

Zheng Li, Xingye Li, Jianxiong Shen, Lin Zhang, Matthew T V Chan, William K K Wu, Zheng Li, Xingye Li, Jianxiong Shen, Lin Zhang, Matthew T V Chan, William K K Wu

Abstract

Scoliosis, a complex three-dimensional deformity of the spine with the Cobb angle (a measure of the spinal lateral curvature) >10 degree, encompasses a spectrum of pathologies, including congenital, idiopathic, syndromic and neuromuscular aetiologies. The pathogenesis is multifactorial involving both environmental and genetic factors but the exact cellular and molecular mechanisms of disease development remain largely unknown. Emerging evidence showed that non-coding RNAs (ncRNAs), namely microRNAs, long ncRNAs and circular RNAs, are deregulated in many orthopaedic diseases, including scoliosis. Importantly, these deregulated ncRNAs functionally participate in the initiation and progression of scoliosis. Here, we review recent progress in ncRNA research on scoliosis.

Keywords: circRNAs; lncRNAs; miRNAs; non-coding RNAs; scoliosis.

Conflict of interest statement

There is no conflict of interest.

© 2019 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.

Figures

Figure 1
Figure 1
Pathogenic mechanism of deregulated ncRNAs in scoliosis

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