Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
Makoto Hirotani, Masaaki Niino, Toshiyuki Fukazawa, Seiji Kikuchi, Ichiro Yabe, Shinsuke Hamada, Yasutaka Tajima, Hidenao Sasaki, Makoto Hirotani, Masaaki Niino, Toshiyuki Fukazawa, Seiji Kikuchi, Ichiro Yabe, Shinsuke Hamada, Yasutaka Tajima, Hidenao Sasaki
Abstract
The complexity of the roles of Toll-like receptors (TLRs) is attributable to their ability to promote or suppress autoimmune diseases. Recent studies have demonstrated that B cells regulate autoimmune diseases, including multiple sclerosis (MS), by producing interleukin (IL)-10. By using CpG DNA as a TLR9 agonist, we investigated the immunoregulatory functions of B cell via TLR9 in MS. Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS.
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Source: PubMed