Neurorehabilitation of Traumatic Brain Injury (TBI): A Clinical Review

Michael Oberholzer, René M Müri, Michael Oberholzer, René M Müri

Abstract

Traumatic brain injury (TBI) and its potential long-term consequences are of major concern for public health. Neurorehabilitation of affected individuals has some specific characteristics in contrast to neurorehabilitation of patients with acquired brain lesions of other aetiology. This review will deal with the clinical consequences of the distinct lesions of TBI. In severe TBI, clinical course often follows a typical initial sequence of coma; followed by disturbed consciousness; later, post-traumatic agitation and amnesia; and finally, recovery of function occurs. In the different phases of neurorehabilitation, physicians should be aware of typical medical complications such as paroxysmal sympathetic hyperactivity, posttraumatic hydrocephalus, and posttraumatic neuroendocrine dysfunctions. Furthermore, we address questions on timing and on existing evidence for different rehabilitation programmes and for holistic neuropsychological rehabilitation approaches.

Keywords: cognitive rehabilitation; disorders of consciousness; neuropsychological rehabilitation; neurorehabilitation; paroxysmal sympathetic hyperactivity; posttraumatic agitation; posttraumatic hydrocephalus; posttraumatic neuroendocrine disorders; traumatic brain injury.

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Thurman D.J., Alverson C., Dunn K.A., Guerrero J., Sniezek J.E. Traumatic brain injury in the United States: A public health perspective. J. Head Trauma Rehabil. 1999;14:602–615. doi: 10.1097/00001199-199912000-00009.
    1. Zaloshnja E., Miller T., Langlois J.A., Selassie A.W. Prevalence of long-term disability from traumatic brain injury in the civilian population of the United States, 2005. J. Head Trauma Rehabil. 2008;23:394–400. doi: 10.1097/.
    1. Walder B., Haller G., Rebetez M.M.L., Delhumeau C., Bottequin E., Schoettker P., Ravussin P., Brodmann Maeder M., Stover J.F., Zürcher M., et al. Severe traumatic brain injury in a high-income country: An epidemiological study. J. Neurotrauma. 2013;30:1934–1942. doi: 10.1089/neu.2013.2955.
    1. Leo P., McCrea M. Epidemiology. In: Laskowitz D., Grant G., editors. Translational Research in Traumatic Brain Injury. CRC Press/Taylor and Francis Group; Boca Raton, FL, USA: 2016. Frontiers in Neuroscience.
    1. Adams J.H., Doyle D., Ford I., Gennarelli T.A., Graham D.I., Mclellan D.R. Diffuse axonal injury in head injury: Definition, diagnosis and grading. Histopathology. 1989;15:49–59. doi: 10.1111/j.1365-2559.1989.tb03040.x.
    1. Christman C.W., Grady M.S., Walker S.A., Holloway K.L., Povlishock J.T. Ultrastructural studies of diffuse axonal injury in humans. J. Neurotrauma. 1994;11:173–186. doi: 10.1089/neu.1994.11.173.
    1. Smith D.H., Meaney D.F., Shull W.H. Diffuse axonal injury in head trauma. J. Head Trauma Rehabil. 2003;18:307–316. doi: 10.1097/00001199-200307000-00003.
    1. Andriessen T.M.J.C., Jacobs B., Vos P.E. Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury. J. Cell. Mol. Med. 2010;14:2381–2392. doi: 10.1111/j.1582-4934.2010.01164.x.
    1. Johnson V.E., Stewart W., Smith D.H. Axonal pathology in traumatic brain injury. Exp. Neurol. 2013;246:35–43. doi: 10.1016/j.expneurol.2012.01.013.
    1. Ma J., Zhang K., Wang Z., Chen G. Progress of Research on Diffuse Axonal Injury after Traumatic Brain Injury. Neural Plast. 2016;2016:9746313. doi: 10.1155/2016/9746313.
    1. Povlishock J.T., Katz D.I. Update of neuropathology and neurological recovery after traumatic brain injury. J. Head Trauma Rehabil. 2005;20:76–94. doi: 10.1097/00001199-200501000-00008.
    1. Kinnunen K.M., Greenwood R., Powell J.H., Leech R., Hawkins P.C., Bonnelle V., Patel M.C., Counsell S.J., Sharp D.J. White matter damage and cognitive impairment after traumatic brain injury. Brain. 2011;134:449–463. doi: 10.1093/brain/awq347.
    1. Skandsen T., Kvistad K.A., Solheim O., Strand I.H., Folvik M., Vik A. Prevalence and impact of diffuse axonal injury in patients with moderate and severe head injury: A cohort study of early magnetic resonance imaging findings and 1-year outcome. J. Neurosurg. 2010;113:556–563. doi: 10.3171/2009.9.JNS09626.
    1. Bigler E.D. The lesion(s) in traumatic brain injury: Implications for clinical neuropsychology. Arch. Clin. Neuropsychol. 2001;16:95–131. doi: 10.1093/arclin/16.2.95.
    1. Bigler E.D. Anterior and middle cranial fossa in traumatic brain injury: Relevant neuroanatomy and neuropathology in the study of neuropsychological outcome. Neuropsychology. 2007;21:515–531. doi: 10.1037/0894-4105.21.5.515.
    1. Fork M., Bartels C., Ebert A.D., Grubich C., Synowitz H., Wallesch C.-W. Neuropsychological sequelae of diffuse traumatic brain injury. Brain Inj. 2005;19:101–108. doi: 10.1080/02699050410001726086.
    1. Scheid R., Walther K., Guthke T., Preul C., von Cramon D.Y. Cognitive sequelae of diffuse axonal injury. Arch. Neurol. 2006;63:418–424. doi: 10.1001/archneur.63.3.418.
    1. Sharp D.J., Scott G., Leech R. Network dysfunction after traumatic brain injury. Nat. Rev. Neurol. 2014;10:156–166. doi: 10.1038/nrneurol.2014.15.
    1. Jang S.H. Review of motor recovery in patients with traumatic brain injury. NeuroRehabilitation. 2009;24:349–353.
    1. Ponsford J.L., Downing M.G., Olver J., Ponsford M., Acher R., Carty M., Spitz G. Longitudinal follow-up of patients with traumatic brain injury: Outcome at two, five, and ten years post-injury. J. Neurotrauma. 2014;31:64–77. doi: 10.1089/neu.2013.2997.
    1. Ponsford J.L., Ziino C., Parcell D.L., Shekleton J.A., Roper M., Redman J.R., Phipps-Nelson J., Rajaratnam S.M.W. Fatigue and sleep disturbance following traumatic brain injury--their nature, causes, and potential treatments. J. Head Trauma Rehabil. 2012;27:224–233. doi: 10.1097/HTR.0b013e31824ee1a8.
    1. Alway Y., Gould K.R., Johnston L., McKenzie D., Ponsford J. A prospective examination of Axis I psychiatric disorders in the first 5 years following moderate to severe traumatic brain injury. Psychol. Med. 2016;46:1331–1341. doi: 10.1017/S0033291715002986.
    1. Posner J.B., Plum F., Saper C.B., Schiff N. Plum and Posner’s Diagnosis of Stupor and Coma. Oxford University Press; New York, NY, USA: 2007.
    1. Giacino J., Whyte J. The Vegetative and Minimally Conscious States. J. Head Trauma Rehabil. 2005;20:30–50. doi: 10.1097/00001199-200501000-00005.
    1. Laureys S., Celesia G.G., Cohadon F., Lavrijsen J., León-Carrión J., Sannita W.G., Sazbon L., Schmutzhard E., von Wild K.R., Zeman A., et al. Unresponsive wakefulness syndrome: A new name for the vegetative state or apallic syndrome. BMC Med. 2010;8:68. doi: 10.1186/1741-7015-8-68.
    1. Giacino J.T., Ashwal S., Childs N., Cranford R., Jennett B., Katz D.I., Kelly J.P., Rosenberg J.H., Whyte J., Zafonte R.D., et al. The minimally conscious state: Definition and diagnostic criteria. Neurology. 2002;58:349–353. doi: 10.1212/WNL.58.3.349.
    1. Giacino J.T., Kalmar K., Whyte J. The JFK Coma Recovery Scale-Revised: Measurement characteristics and diagnostic utility. Arch. Phys. Med. Rehabil. 2004;85:2020–2029. doi: 10.1016/j.apmr.2004.02.033.
    1. Mallinson T., Pape T.L.-B., Guernon A. Responsiveness, Minimal Detectable Change, and Minimally Clinically Important Differences for the Disorders of Consciousness Scale. J. Head Trauma Rehabil. 2016;31:E43–E51. doi: 10.1097/HTR.0000000000000184.
    1. Pignat J.-M., Mauron E., Jöhr J., Gilart de Keranflec’h C., Van De Ville D., Preti M.G., Meskaldji D.E., Hömberg V., Laureys S., Draganski B., et al. Outcome Prediction of Consciousness Disorders in the Acute Stage Based on a Complementary Motor Behavioural Tool. PLoS ONE. 2016;11:e0156882. doi: 10.1371/journal.pone.0156882.
    1. Løvstad M., Andelic N., Knoph R., Jerstad T., Anke A., Skandsen T., Hauger S.L., Giacino J.T., Røe C., Schanke A.-K. Rate of disorders of consciousness in a prospective population-based study of adults with traumatic brain injury. J. Head Trauma Rehabil. 2014;29:E31–E43. doi: 10.1097/HTR.0000000000000017.
    1. Whyte J., Katz D., Long D., DiPasquale M.C., Polansky M., Kalmar K., Giacino J., Childs N., Mercer W., Novak P., et al. Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: A multicenter study. Arch. Phys. Med. Rehabil. 2005;86:453–462. doi: 10.1016/j.apmr.2004.05.016.
    1. Katz D.I., Polyak M., Coughlan D., Nichols M., Roche A. Natural history of recovery from brain injury after prolonged disorders of consciousness: Outcome of patients admitted to inpatient rehabilitation with 1–4 year follow-up. In: Laureys S., Schiff N.D., Owen A.M., editors. Progress in Brain Research. Volume 177. Elsevier; New York, NY, USA: Oxford, UK: Amsterdam, The Netherlands: 2009. pp. 73–88. Coma Science: Clinical and Ethical Implications.
    1. Hammond F.M., Giacino J.T., Nakase Richardson R., Sherer M., Zafonte R.D., Whyte J., Arciniegas D.B., Tang X. Disorders of Consciousness due to Traumatic Brain Injury: Functional Status Ten Years Post-Injury. J. Neurotrauma. 2018 doi: 10.1089/neu.2018.5954.
    1. The Multi-Society Task Force on PVS Medical Aspects of the Persistent Vegetative State. N. Engl. J. Med. 1994;330:1572–1579. doi: 10.1056/NEJM199406023302206.
    1. Lammi M.H., Smith V.H., Tate R.L., Taylor C.M. The minimally conscious state and recovery potential: A follow-up study 2 to 5 years after traumatic brain injury. Arch. Phys. Med. Rehabil. 2005;86:746–754. doi: 10.1016/j.apmr.2004.11.004.
    1. Choi S.C., Barnes T.Y., Bullock R., Germanson T.A., Marmarou A., Young H.F. Temporal profile of outcomes in severe head injury. J. Neurosurg. 1994;81:169–173. doi: 10.3171/jns.1994.81.2.0169.
    1. Arts W., van Dongen H.R., van Hof-van Duin J., Lammens E. Unexpected improvement after prolonged posttraumatic vegetative state. J. Neurol. Neurosurg. Psychiatry. 1985;48:1300–1303. doi: 10.1136/jnnp.48.12.1300.
    1. Levin H.S., Saydjari C., Eisenberg H.M., Foulkes M., Marshall L.F., Ruff R.M., Jane J.A., Marmarou A. Vegetative state after closed-head injury. A Traumatic Coma Data Bank Report. Arch. Neurol. 1991;48:580–585. doi: 10.1001/archneur.1991.00530180032013.
    1. Childs N.L., Mercer W.N. Brief report: Late improvement in consciousness after post-traumatic vegetative state. N. Engl. J. Med. 1996;334:24–25. doi: 10.1056/NEJM199601043340105.
    1. Godbolt A., DeBoussard C., Stenberg M., Lindgren M., Ulfarsson T., Borg J. Disorders of consciousness after severe traumatic brain injury: A Swedish-Icelandic study of incidence, outcomes and implications for optimizing care pathways. J. Rehabil. Med. 2013;45:741–748. doi: 10.2340/16501977-1167.
    1. Schnakers C., Monti M.M. Disorders of consciousness after severe brain injury: Therapeutic options. Curr. Opin. Neurol. 2017;30:573–579. doi: 10.1097/WCO.0000000000000495.
    1. Giacino J.T., Kalmar K., Eifert B., Yablon S.A., Nordenbo A., Maurer-Karattup P. Placebo-Controlled Trial of Amantadine for Severe Traumatic Brain Injury. N. Engl. J. Med. 2012:8. doi: 10.1056/NEJMoa1102609.
    1. Whyte J., Myers R. Incidence of Clinically Significant Responses to Zolpidem Among Patients with Disorders of Consciousness: A Preliminary Placebo Controlled Trial. Am. J. Phys. Med. Rehabil. 2009;88:410–418. doi: 10.1097/PHM.0b013e3181a0e3a0.
    1. Thonnard M., Gosseries O., Demertzi A., Lugo Z., Vanhaudenhuyse A., Bruno M.-A., Chatelle C., Thibaut A., Charland-Verville V., Habbal D., et al. Effect of zolpidem in chronic disorders of consciousness: A prospective open-label study. Funct. Neurol. 2013;28:259.
    1. Meythaler J.M., Depalma L., Devivo M.J., Guin-Renfroe S., Novack T.A. Sertraline to improve arousal and alertness in severe traumatic brain injury secondary to motor vehicle crashes. Brain Inj. 2001;15:321–331. doi: 10.1080/026990501750111274.
    1. Pape T.L.-B., Rosenow J.M., Steiner M., Parrish T., Guernon A., Harton B., Patil V., Bhaumik D.K., McNamee S., Walker M., et al. Placebo-Controlled Trial of Familiar Auditory Sensory Training for Acute Severe Traumatic Brain Injury: A Preliminary Report. Neurorehabil. Neural Repair. 2015;29:537–547. doi: 10.1177/1545968314554626.
    1. Megha M., Harpreet S., Nayeem Z. Effect of frequency of multimodal coma stimulation on the consciousness levels of traumatic brain injury comatose patients. Brain Inj. 2013;27:570–577. doi: 10.3109/02699052.2013.767937.
    1. Cheng L., Cortese D., Monti M.M., Wang F., Riganello F., Arcuri F., Di H., Schnakers C. Do Sensory Stimulation Programs Have an Impact on Consciousness Recovery? Front. Neurol. 2018;9:826. doi: 10.3389/fneur.2018.00826.
    1. Frazzitta G., Zivi I., Valsecchi R., Bonini S., Maffia S., Molatore K., Sebastianelli L., Zarucchi A., Matteri D., Ercoli G., et al. Effectiveness of a Very Early Stepping Verticalization Protocol in Severe Acquired Brain Injured Patients: A Randomized Pilot Study in ICU. PLoS ONE. 2016;11:e0158030. doi: 10.1371/journal.pone.0158030.
    1. Krewer C., Luther M., Koenig E., Müller F. Tilt Table Therapies for Patients with Severe Disorders of Consciousness: A Randomized, Controlled Trial. PLoS ONE. 2015;10:e0143180. doi: 10.1371/journal.pone.0143180.
    1. Baguley I.J., Perkes I.E., Fernandez-Ortega J.-F., Rabinstein A.A., Dolce G., Hendricks H.T. for the Consensus Working Group Paroxysmal Sympathetic Hyperactivity after Acquired Brain Injury: Consensus on Conceptual Definition, Nomenclature, and Diagnostic Criteria. J. Neurotrauma. 2014;31:1515–1520. doi: 10.1089/neu.2013.3301.
    1. Perkes I., Baguley I.J., Nott M.T., Menon D.K. A review of paroxysmal sympathetic hyperactivity after acquired brain injury. Ann. Neurol. 2010;68:126–135. doi: 10.1002/ana.22066.
    1. Eapen B., Allred D., O’Rourke J., Cifu D. Rehabilitation of Moderate-to-Severe Traumatic Brain Injury. Semin. Neurol. 2015;35:e1–e13.
    1. Warden D.L., Gordon B., McAllister T.W., Silver J.M., Barth J.T., Bruns J., Drake A., Gentry T., Jagoda A., Katz D.I., et al. Guidelines for the Pharmacologic Treatment of Neurobehavioral Sequelae of Traumatic Brain Injury. J. Neurotrauma. 2006;23:1468–1501. doi: 10.1089/neu.2006.23.1468.
    1. Lombardi F. Pharmacological treatment of neurobehavioural sequelae of traumatic brain injury. Eur. J. Anaesthesiol. Suppl. 2008;42:131–136. doi: 10.1017/S0265021507003316.
    1. Luauté J., Plantier D., Wiart L., Tell L. Care management of the agitation or aggressiveness crisis in patients with TBI. Systematic review of the literature and practice recommendations. Ann. Phys. Rehabil. Med. 2016;59:58–67. doi: 10.1016/j.rehab.2015.11.001.
    1. Fleminger S., Greenwood R.R., Oliver D.L. Pharmacological management for agitation and aggression in people with acquired brain injury. Cochrane Database Syst. Rev. 2006 doi: 10.1002/14651858.CD003299.pub2.
    1. Sessler C.N., Gosnell M.S., Grap M.J., Brophy G.M., O’Neal P.V., Keane K.A., Tesoro E.P., Elswick R.K. The Richmond Agitation–Sedation Scale: Validity and Reliability in Adult Intensive Care Unit Patients. Am. J. Respir. Crit. Care Med. 2002;166:1338–1344. doi: 10.1164/rccm.2107138.
    1. Robinson D., Thompson S., Bauerschmidt A., Melmed K., Couch C., Park S., Agarwal S., Roh D., Connolly E.S., Claassen J. Dispersion in Scores on the Richmond Agitation and Sedation Scale as a Measure of Delirium in Patients with Subdural Hematomas. Neurocrit. Care. 2018 doi: 10.1007/s12028-018-0649-y.
    1. Bogner J.A., Corrigan J.D., Bode R.K., Heinemann A.W. Rating Scale Analysis of the Agitated Behavior Scale. J. Head Trauma Rehabil. 2000;15:656–669. doi: 10.1097/00001199-200002000-00005.
    1. Guyot L.L., Michael D.B. Post-traumatic hydrocephalus. Neurol. Res. 2000;22:25–28. doi: 10.1080/01616412.2000.11741034.
    1. Mazzini L., Campini R., Angelino E., Rognone F., Pastore I., Oliveri G. Posttraumatic hydrocephalus: A clinical, neuroradiologic, and neuropsychologic assessment of long-term outcome. Arch. Phys. Med. Rehabil. 2003;84:1637–1641. doi: 10.1053/S0003-9993(03)00314-9.
    1. Kammersgaard L.P., Linnemann M., Tibæk M. Hydrocephalus following severe traumatic brain injury in adults. Incidence, timing, and clinical predictors during rehabilitation. NeuroRehabilitation. 2013;33:473–480.
    1. Weintraub A.H., Gerber D.J., Kowalski R.G. Posttraumatic Hydrocephalus as a Confounding Influence on Brain Injury Rehabilitation: Incidence, Clinical Characteristics, and Outcomes. Arch. Phys. Med. Rehabil. 2017;98:312–319. doi: 10.1016/j.apmr.2016.08.478.
    1. Tian H.-L., Xu T., Hu J., Cui Y., Chen H., Zhou L.-F. Risk factors related to hydrocephalus after traumatic subarachnoid hemorrhage. Surg. Neurol. 2008;69:241–246. doi: 10.1016/j.surneu.2007.02.032.
    1. Denes Z., Barsi P., Szel I., Boros E., Fazekas G. Complication during postacute rehabilitation: Patients with posttraumatic hydrocephalus. Int. J. Rehabil. Res. 2011;34:222–226. doi: 10.1097/MRR.0b013e328346e87d.
    1. Daou B., Klinge P., Tjoumakaris S., Rosenwasser R.H., Jabbour P. Revisiting secondary normal pressure hydrocephalus: Does it exist? A review. Neurosurg. Focus. 2016;41:E6. doi: 10.3171/2016.6.FOCUS16189.
    1. Wen L., Wan S., Zhan R.Y., Li G., Gong J.B., Liu W.G., Yang X.F. Shunt implantation in a special sub-group of post-traumatic hydrocephalus–patients have normal intracranial pressure without clinical representations of hydrocephalus. Brain Inj. 2009;23:61–64. doi: 10.1080/02699050802635265.
    1. Webb N.E., Little B., Loupee-Wilson S., Power E.M. Traumatic brain injury and neuro-endocrine disruption: Medical and psychosocial rehabilitation. NeuroRehabilitation. 2014;34:625–636.
    1. Klose M., Feldt-Rasmussen U. Chronic endocrine consequences of traumatic brain injury—What is the evidence? Nat. Rev. Endocrinol. 2017;14:57–62. doi: 10.1038/nrendo.2017.103.
    1. Agha A., Rogers B., Mylotte D., Taleb F., Tormey W., Phillips J., Thompson C.J. Neuroendocrine dysfunction in the acute phase of traumatic brain injury. Clin. Endocrinol. 2004;60:584–591. doi: 10.1111/j.1365-2265.2004.02023.x.
    1. Schneider H.J., Schneider M., Kreitschmann-Andermahr I., Tuschy U., Wallaschofski H., Fleck S., Faust M., Renner C.I.E., Kopczak A., Saller B., et al. Structured assessment of hypopituitarism after traumatic brain injury and aneurysmal subarachnoid hemorrhage in 1242 patients: The German interdisciplinary database. J. Neurotrauma. 2011;28:1693–1698. doi: 10.1089/neu.2011.1887.
    1. Krewer C., Schneider M., Schneider H.J., Kreitschmann-Andermahr I., Buchfelder M., Faust M., Berg C., Wallaschofski H., Renner C., Uhl E., et al. Neuroendocrine Disturbances One to Five or More Years after Traumatic Brain Injury and Aneurysmal Subarachnoid Hemorrhage: Data from the German Database on Hypopituitarism. J. Neurotrauma. 2016;33:1544–1553. doi: 10.1089/neu.2015.4109.
    1. Quinn M., Agha A. Post-Traumatic Hypopituitarism—Who Should Be Screened, When, and How? Front. Endocrinol. 2018;9 doi: 10.3389/fendo.2018.00008.
    1. Hannon M.J., Crowley R.K., Behan L.A., O’Sullivan E.P., O’Brien M.M.C., Sherlock M., Rawluk D., O’Dwyer R., Tormey W., Thompson C.J. Acute glucocorticoid deficiency and diabetes insipidus are common after acute traumatic brain injury and predict mortality. J. Clin. Endocrinol. Metab. 2013;98:3229–3237. doi: 10.1210/jc.2013-1555.
    1. Shafi S., Barnes S.A., Millar D., Sobrino J., Kudyakov R., Berryman C., Rayan N., Dubiel R., Coimbra R., Magnotti L.J., et al. Suboptimal compliance with evidence-based guidelines in patients with traumatic brain injuries. J. Neurosurg. 2014;120:773–777. doi: 10.3171/2013.12.JNS132151.
    1. Schumacher R., Walder B., Delhumeau C., Müri R.M. Predictors of inpatient (neuro)rehabilitation after acute care of severe traumatic brain injury: An epidemiological study. Brain Inj. 2016;30:1186–1193. doi: 10.1080/02699052.2016.1183821.
    1. Sveen U., Røe C., Sigurdardottir S., Skandsen T., Andelic N., Manskow U., Berntsen S.A., Soberg H.L., Anke A. Rehabilitation pathways and functional independence one year after severe traumatic brain injury. Eur. J. Phys. Rehabil. Med. 2016;52:650–661.
    1. Odgaard L., Poulsen I., Kammersgaard L.P., Johnsen S.P., Nielsen J.F. Surviving severe traumatic brain injury in Denmark: Incidence and predictors of highly specialized rehabilitation. Clin. Epidemiol. 2015;7:225–234. doi: 10.2147/CLEP.S78141.
    1. Greenwald B.D., Rigg J.L. Neurorehabilitation in traumatic brain injury: Does it make a difference? Mt. Sinai J. Med. N. Y. 2009;76:182–189. doi: 10.1002/msj.20103.
    1. Lamontagne M.-E., Truchon C., Kagan C., Bayley M., Swaine B., Marshall S., Kua A., Allaire A.-S., Marier Deschenes P., Gargaro J. INESSS-ONF Clinical Practice Guidelines for the Rehabilitation of Adults Having Sustained a Moderate-To-Severe TBI. Taylor & Francis Inc.; Philadelphia, PA, USA: 2016.
    1. Cnossen M.C., Lingsma H.F., Tenovuo O., Maas A.I.R., Menon D., Steyerberg E.W., Ribbers G.M., Polinder S. Rehabilitation after traumatic brain injury: A survey in 70 European neurotrauma centres participating in the CENTER-TBI study. J. Rehabil. Med. 2017;49:395–401. doi: 10.2340/16501977-2216.
    1. Schumacher R., Müri R.M., Walder B. Integrated Health Care Management of Moderate to Severe TBI in Older Patients-A Narrative Review. Curr. Neurol. Neurosci. Rep. 2017;17:92. doi: 10.1007/s11910-017-0801-7.
    1. Turner-Stokes L., Pick A., Nair A., Disler P.B., Wade D.T. Multi-disciplinary rehabilitation for acquired brain injury in adults of working age. Cochrane Database Syst. Rev. 2015;12:CD004170. doi: 10.1002/14651858.CD004170.pub3.
    1. Turner-Stokes L. Evidence for the effectiveness of multi-disciplinary rehabilitation following acquired brain injury: A synthesis of two systematic approaches. J. Rehabil. Med. 2008;40:691–701. doi: 10.2340/16501977-0265.
    1. Atkins D., Briss P.A., Eccles M., Flottorp S., Guyatt G.H., Harbour R.T., Hill S., Jaeschke R., Liberati A., Magrini N., et al. Systems for grading the quality of evidence and the strength of recommendations II: Pilot study of a new system. BMC Health Serv. Res. 2005;5:25. doi: 10.1186/1472-6963-5-25.
    1. Andelic N., Bautz-Holter E., Ronning P., Olafsen K., Sigurdardottir S., Schanke A.-K., Sveen U., Tornas S., Sandhaug M., Roe C. Does an Early Onset and Continuous Chain of Rehabilitation Improve the Long-Term Functional Outcome of Patients with Severe Traumatic Brain Injury? J. Neurotrauma. 2012;29:66–74. doi: 10.1089/neu.2011.1811.
    1. Königs M., Beurskens E.A., Snoep L., Scherder E.J., Oosterlaan J. Effects of Timing and Intensity of Neurorehabilitation on Functional Outcome After Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Arch. Phys. Med. Rehabil. 2018;99:1149–1159. doi: 10.1016/j.apmr.2018.01.013.
    1. Formisano R., Azicnuda E., Sefid M.K., Zampolini M., Scarponi F., Avesani R. Early rehabilitation: Benefits in patients with severe acquired brain injury. Neurol. Sci. 2017;38:181–184. doi: 10.1007/s10072-016-2724-5.
    1. Zhu X.L., Poon W.S., Chan C.H., Chan S.H. Does intensive rehabilitation improve the functional outcome of patients with traumatic brain injury? Interim result of a randomized controlled trial. Br. J. Neurosurg. 2001;15:464–473. doi: 10.1080/02688690120097688.
    1. Shiel A., Burn J.P., Henry D., Clark J., Wilson B.A., Burnett M.E., McLellan D.L. The effects of increased rehabilitation therapy after brain injury: Results of a prospective controlled trial. Clin. Rehabil. 2001;15:501–514. doi: 10.1191/026921501680425225.
    1. Hart T., Whyte J., Poulsen I., Kristensen K.S., Nordenbo A.M., Chervoneva I., Vaccaro M.J. How Do Intensity and Duration of Rehabilitation Services Affect Outcomes from Severe Traumatic Brain Injury? A Natural Experiment Comparing Health Care Delivery Systems in 2 Developed Nations. Arch. Phys. Med. Rehabil. 2016;97:2045–2053. doi: 10.1016/j.apmr.2016.07.012.
    1. Slade A., Tennant A., Chamberlain M.A. A randomised controlled trial to determine the effect of intensity of therapy upon length of stay in a neurological rehabilitation setting. J. Rehabil. Med. 2002;34:260–266. doi: 10.1080/165019702760390347.
    1. Formisano R., Contrada M., Aloisi M., Buzzi M.G., Cicinelli P., Vedova C.D., Laurenza L., Matteis M., Spanedda F., Vinicola V., et al. Improvement rate of patients with severe brain injury during post-acute intensive rehabilitation. Neurol. Sci. 2018;39:753–755. doi: 10.1007/s10072-017-3203-3.
    1. McLafferty F.S., Barmparas G., Ortega A., Roberts P., Ko A., Harada M., Nuño M., Black K.L., Ley E.J. Predictors of improved functional outcome following inpatient rehabilitation for patients with traumatic brain injury. NeuroRehabilitation. 2016;39:423–430. doi: 10.3233/NRE-161373.
    1. Foy C.M.L., Somers J.S. Increase in functional abilities following a residential educational and neurorehabilitation programme in young adults with acquired brain injury. NeuroRehabilitation. 2013;32:671–678.
    1. Turner-Stokes L. Cost-efficiency of longer-stay rehabilitation programmes: Can they provide value for money? Brain Inj. 2007;21:1015–1021. doi: 10.1080/02699050701591445.
    1. Institute of Medicine . Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence. The National Academics Press; Washington, DC, USA: 2011.
    1. Brasure M., Lamberty G.J., Sayer N.A., Nelson N.W., MacDonald R., Ouellette J., Wilt T.J. Participation After Multidisciplinary Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults: A Systematic Review. Arch. Phys. Med. Rehabil. 2013;94:1398–1420. doi: 10.1016/j.apmr.2012.12.019.
    1. Cicerone K.D., Mott T., Azulay J., Sharlow-Galella M.A., Ellmo W.J., Paradise S., Friel J.C. A randomized controlled trial of holistic neuropsychologic rehabilitation after traumatic brain injury. Arch. Phys. Med. Rehabil. 2008;89:2239–2249. doi: 10.1016/j.apmr.2008.06.017.
    1. Cicerone K.D., Langenbahn D.M., Braden C., Malec J.F., Kalmar K., Fraas M., Felicetti T., Laatsch L., Harley J.P., Bergquist T., et al. Evidence-based cognitive rehabilitation: Updated review of the literature from 2003 through 2008. Arch. Phys. Med. Rehabil. 2011;92:519–530. doi: 10.1016/j.apmr.2010.11.015.
    1. Bayley M.T., Tate R., Douglas J.M., Turkstra L.S., Ponsford J., Stergiou-Kita M., Kua A., Bragge P. INCOG Expert Panel INCOG guidelines for cognitive rehabilitation following traumatic brain injury: Methods and overview. J. Head Trauma Rehabil. 2014;29:290–306. doi: 10.1097/HTR.0000000000000070.
    1. Scottish Intercollegiate Guidelines Network (SIGN) Brain Injury Rehabilitation in Adults: A National Clinical Guideline. SIGN; Edinburgh, UK: 2013. SIGN Publication No. 130.

Source: PubMed

Подписаться