Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study
Caroline Jézéquel, Fabrice Lainé, Bruno Laviolle, Anita Kiani, Edouard Bardou-Jacquet, Yves Deugnier, Caroline Jézéquel, Fabrice Lainé, Bruno Laviolle, Anita Kiani, Edouard Bardou-Jacquet, Yves Deugnier
Abstract
Background & aims: Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI).
Methods: We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L.
Results: The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p<0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies.
Conflict of interest statement
Competing Interests: The authors have declared that no competing interests exist.
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