Inflammation related miRNAs as an important player between obesity and cancers

Morteza Gholami, Bagher Larijani, Zhila Zahedi, Fatemeh Mahmoudian, Samira Bahrami, Sima Parvizi Omran, Zahra Saadatian, Shirin Hasani-Ranjbar, Reza Taslimi, Milad Bastami, Mahsa M Amoli, Morteza Gholami, Bagher Larijani, Zhila Zahedi, Fatemeh Mahmoudian, Samira Bahrami, Sima Parvizi Omran, Zahra Saadatian, Shirin Hasani-Ranjbar, Reza Taslimi, Milad Bastami, Mahsa M Amoli

Abstract

The growing trend in addition to their burden, prevalence, and death has made obesity and cancer two of the most concerning diseases worldwide. Obesity is an important risk factor for common types of cancers where the risk of some cancers is directly related to the obesity. Various inflammatory mechanisms and increased level of pro-inflammatory cytokines have been investigated in many previous studies, which play key roles in the pathophysiology and development of both of these conditions. On the other hand, in the recent years, many studies have individually focused on the biomarker's role and therapeutic targeting of microRNAs (miRNAs) in different types of cancers and obesity including newly discovered small noncoding RNAs (sncRNAs) which regulate gene expression and RNA silencing. This study is a comprehensive review of the main inflammation related miRNAs in obesity/obesity related traits. For the first time, the main roles of miRNAs in obesity related cancers have been discussed in response to the question raised in the following hypothesis; do the main inflammatory miRNAs link obesity with obesity-related cancers regarding their role as biomarkers? Graphical abstractConceptual design of inflammatory miRNAs which provide link between obesity and cancers.

Keywords: Cancer; Inflammation; MicroRNAs; Obesity.