Peri-implant soft tissue phenotype modification and its impact on peri-implant health: A systematic review and network meta-analysis

Lorenzo Tavelli, Shayan Barootchi, Gustavo Avila-Ortiz, Istvan A Urban, William V Giannobile, Hom-Lay Wang, Lorenzo Tavelli, Shayan Barootchi, Gustavo Avila-Ortiz, Istvan A Urban, William V Giannobile, Hom-Lay Wang

Abstract

Background: The peri-implant soft tissue phenotype (PSP) encompasses the keratinized mucosa width (KMW), mucosal thickness (MT), and supracrestal tissue height (STH). Numerous approaches to augment soft tissue volume around endosseous dental implants have been investigated. To what extent PSP modification is beneficial for peri-implant health has been subject of debate in the field of implant dentistry. The aim of this systematic review was to analyze the evidence regarding the efficacy of soft tissue augmentation procedures aimed at modifying the PSP and their impact on peri-implant health.

Methods: A comprehensive search was performed to identify clinical studies that involved soft tissue augmentation around dental implants and reported findings on KMW, MT, and/or STH changes. The effect of the intervention on peri-implant health was also assessed. Selected articles were classified based on the general type of surgical approach to increase PSP, either bilaminar or an apically positioned flap (APF) technique. A network meta-analysis including only randomized-controlled trials (RCTs) reporting on PSP outcomes was conducted to assess and compare different techniques.

Results: A total of 52 articles were included in the qualitative analysis, and 23 RCTs were included as part of the network meta-analysis. Sixteen RCTs reported the outcomes of PSP modification therapy with bilaminar techniques, whereas 7 involved the use of APF. The analysis showed that bilaminar techniques in combination with soft tissue grafts (connective tissue graft [CTG], collagen matrix [CM], and acellular dermal matrix [ADM]) resulted in a significant increase in MT compared to non-augmented sites. In particular, CTG and ADM were associated with higher MT gain as compared to CM and non-augmented sites. However, no significant differences in KMW were observed across different bilaminar techniques. PSP modification via a bilaminar approach utilizing either CTG or CM showed beneficial effects on marginal bone level stability. APF-based approaches in combination with free gingival graft (FGG), CTG, CM, or ADM showed a significant KMW gain compared to non-augmented sites. However, compared to APF alone, only FGG exhibited a significantly higher KMW gain. APF with any evaluated soft tissue graft was associated with with reduction of probing depth, soft tissue dehiscence and plaque index compared to non-augmented sites compared to non-augmented sites. The evidence regarding the effect of PSP modification via APF-based approaches on peri-implant marginal bone loss or preservation is inconclusive.

Conclusions: Bilaminar approach involving CTG or ADM obtained the highest amount of MT gain, whereas APF in combination with FGG was the most effective technique for increasing KMW. KMW augmentation via APF was associated with a significant reduction in probing depth, soft tissue dehiscence and plaque index, regardless of the soft tissue grafting material employed, whereas bilaminar techniques with CTG or CM showed beneficial effects on marginal bone level stability.

Keywords: acellular dermal graft; autogenous grafts; collagen matrix; dental implant; evidence-based dentistry; network meta-analysis; soft tissue augmentation; tissue graft.

© 2020 American Academy of Periodontology.

References

REFERENCES

    1. Buser D, Sennerby L, De Bruyn H. Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions. Periodontol 2000. 2017;73:7-21.
    1. Ravida A, Wang IC, Barootchi S, et al. Meta-analysis of randomized clinical trials comparing clinical and patient-reported outcomes between extra-short (</ = 6 mm) and longer (>/ = 10 mm) implants. J Clin Periodontol. 2019;46:118-142.
    1. Ravida A, Barootchi S, Askar H, Suarez-Lopez Del Amo F, Tavelli L, Wang HL. Long-term effectiveness of extra-short (</ = 6 mm) dental implants: a systematic review. Int J Oral Maxillofac Implants. 2019;34:68-84.
    1. Barootchi S, Ravida A, Tavelli L, Wang HL. Nonsurgical treatment for peri-implant mucositis: a systematic review and meta-analysis. Int J Oral Implantol (Berl). 2020;13:123-139.
    1. Spray JR, Black CG, Morris HF, Ochi S. The influence of bone thickness on facial marginal bone response: stage 1 placement through stage 2 uncovering. Ann Periodontol. 2000;5:119-128.
    1. Jepsen S, Schwarz F, Cordaro L, et al. Regeneration of alveolar ridge defects. Consensus report of group 4 of the 15th European Workshop on periodontology on bone regeneration. J Clin Periodontol. 2019;46(Suppl 21):277-286.
    1. Benic GI, Hammerle CH. Horizontal bone augmentation by means of guided bone regeneration. Periodontol 2000. 2014;66:13-40.
    1. Naenni N, Lim HC, Papageorgiou SN, Hammerle CHF. Efficacy of lateral bone augmentation prior to implant placement: a systematic review and meta-analysis. J Clin Periodontol. 2019;46(Suppl 21):287-306.
    1. Thoma DS, Muhlemann S, Jung RE. Critical soft-tissue dimensions with dental implants and treatment concepts. Periodontol 2000. 2014;66:106-118.
    1. Thoma DS, Naenni N, Figuero E, et al. Effects of soft tissue augmentation procedures on peri-implant health or disease: a systematic review and meta-analysis. Clin Oral Implants Res. 2018;29(Suppl 15):32-49.
    1. Bassetti RG, Stahli A, Bassetti MA, Sculean A. Soft tissue augmentation procedures at second-stage surgery: a systematic review. Clin Oral Investig. 2016;20:1369-1387.
    1. Cairo F, Pagliaro U, Nieri M. Soft tissue management at implant sites. J Clin Periodontol. 2008;35:163-167.
    1. Giannobile WV, Jung RE, Schwarz F, Groups of the 2nd Osteology Foundation Consensus Meeting. Evidence-based knowledge on the aesthetics and maintenance of peri-implant soft tissues: Osteology Foundation Consensus Report Part 1-Effects of soft tissue augmentation procedures on the maintenance of peri-implant soft tissue health. Clin Oral Implants Res. 2018;29(Suppl 15):7-10.
    1. Warrer K, Buser D, Lang NP, Karring T. Plaque-induced peri-implantitis in the presence or absence of keratinized mucosa. An experimental study in monkeys. Clin Oral Implants Res. 1995;6:131-138.
    1. Grischke J, Karch A, Wenzlaff A, Foitzik MM, Stiesch M, Eberhard J. Keratinized mucosa width is associated with severity of peri-implant mucositis. A cross-sectional study. Clin Oral Implants Res. 2019;30:457-465.
    1. Monje A, Blasi G. Significance of keratinized mucosa/gingiva on peri-implant and adjacent periodontal conditions in erratic maintenance compliers. J Periodontol. 2019;90:445-453.
    1. Perussolo J, Souza AB, Matarazzo F, Oliveira RP, Araujo MG. Influence of the keratinized mucosa on the stability of peri-implant tissues and brushing discomfort: a 4-year follow-up study. Clin Oral Implants Res. 2018;29:1177-1185.
    1. Lin GH, Chan HL, Wang HL. The significance of keratinized mucosa on implant health: a systematic review. J Periodontol. 2013;84:1755-1767.
    1. Bouri A, Jr., Bissada N, Al-Zahrani MS, Faddoul F, Nouneh I. Width of keratinized gingiva and the health status of the supporting tissues around dental implants. Int J Oral Maxillofac Implants. 2008;23:323-326.
    1. Strub JR, Gaberthuel TW, Grunder U. The role of attached gingiva in the health of peri-implant tissue in dogs. 1. Clinical findings. Int J Periodontics Restorative Dent. 1991;11:317-333.
    1. Schou S, Holmstrup P, Hjorting-Hansen E, Lang NP. Plaque-induced marginal tissue reactions of osseointegrated oral implants: a review of the literature. Clin Oral Implants Res. 1992;3:149-161.
    1. Wennstrom JL, Derks J. Is there a need for keratinized mucosa around implants to maintain health and tissue stability?. Clin Oral Implants Res. 2012;23(Suppl 6):136-146.
    1. Adibrad M, Shahabuei M, Sahabi M. Significance of the width of keratinized mucosa on the health status of the supporting tissue around implants supporting overdentures. J Oral Implantol. 2009;35:232-237.
    1. Roccuzzo M, Grasso G, Dalmasso P. Keratinized mucosa around implants in partially edentulous posterior mandible: 10-year results of a prospective comparative study. Clin Oral Implants Res. 2016;27:491-496.
    1. Schwarz F, Becker J, Civale S, Sahin D, Iglhaut T, Iglhaut G. Influence of the width of keratinized tissue on the development and resolution of experimental peri-implant mucositis lesions in humans. Clin Oral Implants Res. 2018;29:576-582.
    1. Bonino F, Steffensen B, Natto Z, Hur Y, Holtzman LP, Weber HP. Prospective study of the impact of peri-implant soft tissue properties on patient-reported and clinically assessed outcomes. J Periodontol. 2018;89:1025-1032.
    1. Stefanini M, Felice P, Mazzotti C, Mounssif I, Marzadori M, Zucchelli G. Esthetic evaluation and patient-centered outcomes in single-tooth implant rehabilitation in the esthetic area. Periodontol 2000. 2018;77:150-164.
    1. Zucchelli G, Sharma P, Mounssif I. Esthetics in periodontics and implantology. Periodontol 2000. 2018;77:7-18.
    1. Juodzbalys G, Wang HL. Esthetic index for anterior maxillary implant-supported restorations. J Periodontol. 2010;81:34-42.
    1. Furhauser R, Florescu D, Benesch T, Haas R, Mailath G, Watzek G. Evaluation of soft tissue around single-tooth implant crowns: the pink esthetic score. Clin Oral Implants Res. 2005;16:639-644.
    1. Jung RE, Sailer I, Hammerle CH, Attin T, Schmidlin P. In vitro color changes of soft tissues caused by restorative materials. Int J Periodontics Restorative Dent. 2007;27:251-257.
    1. Hosseini M, Worsaae N, Gotfredsen K. Tissue changes at implant sites in the anterior maxilla with and without connective tissue grafting: a five-year prospective study. Clin Oral Implants Res. 2020;31:18-28.
    1. Lops D, Stellini E, Sbricoli L, Cea N, Romeo E, Bressan E. Influence of abutment material on peri-implant soft tissues in anterior areas with thin gingival biotype: a multicentric prospective study. Clin Oral Implants Res. 2017;28:1263-1268.
    1. Zucchelli G, Felice P, Mazzotti C, et al. 5-year outcomes after coverage of soft tissue dehiscence around single implants: a prospective cohort study. Eur J Oral Implantol. 2018;11:215-224.
    1. Zucchelli G, Tavelli L, Stefanini M, et al. Classification of facial peri-implant soft tissue dehiscence/deficiencies at single implant sites in the esthetic zone. J Periodontol. 2019;90:1116-1124.
    1. Zuiderveld EG, Meijer HJA, den Hartog L, Vissink A, Raghoebar GM. Effect of connective tissue grafting on peri-implant tissue in single immediate implant sites: a RCT. J Clin Periodontol. 2018;45:253-264.
    1. Mazzotti C, Stefanini M, Felice P, Bentivogli V, Mounssif I, Zucchelli G. Soft-tissue dehiscence coverage at peri-implant sites. Periodontol 2000. 2018;77:256-272.
    1. Fu JH, Su CY, Wang HL. Esthetic soft tissue management for teeth and implants. J Evid Based Dent Pract. 2012;12:129-142.
    1. Berglundh T, Lindhe J. Dimension of the periimplant mucosa. Biological width revisited. J Clin Periodontol. 1996;23:971-973.
    1. Linkevicius T, Apse P, Grybauskas S, Puisys A. The influence of soft tissue thickness on crestal bone changes around implants: a 1-year prospective controlled clinical trial. Int J Oral Maxillofac Implants. 2009;24:712-719.
    1. Puisys A, Linkevicius T. The influence of mucosal tissue thickening on crestal bone stability around bone-level implants. A prospective controlled clinical trial. Clin Oral Implants Res. 2015;26:123-129.
    1. Linkevicius T, Linkevicius R, Alkimavicius J, Linkeviciene L, Andrijauskas P, Puisys A. Influence of titanium base, lithium disilicate restoration and vertical soft tissue thickness on bone stability around triangular-shaped implants: a prospective clinical trial. Clin Oral Implants Res. 2018;29:716-724.
    1. Diaz-Sanchez M, Soto-Penaloza D, Penarrocha-Oltra D, Penarrocha-Diago M. Influence of supracrestal tissue attachment thickness on radiographic bone level around dental implants: a systematic review and meta-analysis. J Periodontal Res. 2019;54:573-588.
    1. Avila-Ortiz G, Gonzalez-Martin O, Couso-Queiruga E, Wang HL. The peri-implant phenotype. J Periodontol. 2020;91:283-288.
    1. Tavelli L, Barootchi S, Cairo F, Rasperini G, Shedden K, Wang HL. The effect of time on root coverage outcomes: a network meta-analysis. J Dent Res. 2019;98:1195-1203.
    1. Zucchelli G, Tavelli L, McGuire MK, et al. Autogenous soft tissue grafting for periodontal and peri-implant plastic surgical reconstruction. J Periodontol. 2020;91:9-16.
    1. Tavelli L, Barootchi S, Ravida A, Oh TJ, Wang HL. What is the safety zone for palatal soft tissue graft harvesting based on the locations of the greater palatine artery and foramen? A systematic review. J Oral Maxillofac Surg. 2019;77: 271.e1-271.e9.
    1. Tavelli L, Ravida A, Saleh MHA, et al. Pain perception following epithelialized gingival graft harvesting: a randomized clinical trial. Clin Oral Investig. 2019;23:459-468.
    1. Tavelli L, McGuire MK, Zucchelli G, et al. Extracellular matrix-based scaffolding technologies for periodontal and peri-implant soft tissue regeneration. J Periodontol. 2020;91:17-25.
    1. Stefanini M, Mounssif I, Barootchi S, Tavelli L, Wang HL, Zucchelli G. An exploratory clinical study evaluating safety and performance of a volume-stable collagen matrix with coronally advanced flap for single gingival recession treatment. Clin Oral Investig. 2020. .
    1. Thoma DS, Buranawat B, Hammerle CH, Held U, Jung RE. Efficacy of soft tissue augmentation around dental implants and in partially edentulous areas: a systematic review. J Clin Periodontol. 2014;41(Suppl 15):S77-S91.
    1. Cairo F, Barbato L, Selvaggi F, Baielli MG, Piattelli A, Chambrone L. Surgical procedures for soft tissue augmentation at implant sites. A systematic review and meta-analysis of randomized controlled trials. Clin Implant Dent Relat Res. 2019;21:1262-1270.
    1. . . Accessed: 11/29/2019.
    1. Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.
    1. Hutton B, Salanti G, Caldwell DM, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162:777-784.
    1. Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;350:g7647.
    1. Berglundh T, Armitage G, Araujo MG, et al. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 2018;89(Suppl 1):S313-S318.
    1. Hammerle CHF, Tarnow D. The etiology of hard- and soft-tissue deficiencies at dental implants: a narrative review. J Periodontol. 2018;89(Suppl 1):S291-S303.
    1. Stillwell SB, Fineout-Overholt E, Melnyk BM, Williamson KM. Evidence-based practice, step by step: asking the clinical question: a key step in evidence-based practice. Am J Nurs. 2010;110:58-61.
    1. Berglundh T, Armitage G, Araujo MG, et al. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the classification of periodontal and peri-implant diseases and conditions. J Clin Periodontol. 2018;45(Suppl 20):S286-S291.
    1. . Accessed: 3/26/2020.
    1. Bassetti RG, Stahli A, Bassetti MA, Sculean A. Soft tissue augmentation around osseointegrated and uncovered dental implants: a systematic review. Clin Oral Investig. 2017;21:53-70.
    1. Gargallo-Albiol J, Barootchi S, Tavelli L, Wang HL. Efficacy of xenogeneic collagen matrix to augment peri-implant soft tissue thickness compared to autogenous connective tissue graft: a systematic review and meta-analysis. Int J Oral Maxillofac Implants. 2019;34:1059-1069.
    1. Gobbato L, Avila-Ortiz G, Sohrabi K, Wang CW, Karimbux N. The effect of keratinized mucosa width on peri-implant health: a systematic review. Int J Oral Maxillofac Implants. 2013;28:1536-1545.
    1. Lin CY, Chen Z, Pan WL, Wang HL. Impact of timing on soft tissue augmentation during implant treatment: a systematic review and meta-analysis. Clin Oral Implants Res. 2018;29:508-521.
    1. Poskevicius L, Sidlauskas A, Galindo-Moreno P, Juodzbalys G. Dimensional soft tissue changes following soft tissue grafting in conjunction with implant placement or around present dental implants: a systematic review. Clin Oral Implants Res. 2017;28:1-8.
    1. Rotundo R, Pagliaro U, Bendinelli E, Esposito M, Buti J. Long-term outcomes of soft tissue augmentation around dental implants on soft and hard tissue stability: a systematic review. Clin Oral Implants Res. 2015;26(Suppl 11):123-138.
    1. Suarez-Lopez Del Amo F, Lin GH, Monje A, Galindo-Moreno P, Wang HL. Influence of soft tissue thickness on peri-implant marginal bone loss: a systematic review and meta-analysis. J Periodontol. 2016;87:690-699.
    1. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand. 1963;21:533-551.
    1. Sterne JA, Hernan MA, Reeves BC, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919.
    1. Moola S, Munn Z, Tufanaru C. Joanna Briggs Institute Reviewer's Manual. In: Aromataris E, Munn Z, eds. Systematic Reviews of Etiology and Risk. The Joanna Briggs Institute; 2017.
    1. Barootchi S, Tavelli L, Zucchelli G, Giannobile WV, Wang HL. Gingival phenotype modification therapies on natural teeth: a network meta-analysis. J Periodontol. 2020. .
    1. Cairo F, Barootchi S, Tavelli L, et al. Esthetic- and patient-related outcomes following root coverage procedures: a systematic review and network meta-analysis. J Clin Periodontol. 2020. .
    1. Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67:1-48.
    1. Kuznetsova A, Brockhoff PB, Christensen RHB. ImerTest package: tests in linear mixed effects models. J Stat Softw. 2017;82:1-26.
    1. Wickham H, François R, Henry L, Müller K, dplyr: a grammar of data manipulation. 2019.
    1. Wickham H, Henry L, tidyr: Tidy Messy Data. 2019.
    1. Csardi GN, Nepusz T. The igraph software package for complex network research. InterJournal. 2006:1695. Complex Systems.
    1. Wickham H, ggplot2: Elegant Graphics for Data Analysis. 2016.
    1. Anderson LE, Inglehart MR, El-Kholy K, Eber R, Wang HL. Implant associated soft tissue defects in the anterior maxilla: a randomized control trial comparing subepithelial connective tissue graft and acellular dermal matrix allograft. Implant Dent. 2014;23:416-425.
    1. Basegmez C, Ersanli S, Demirel K, Bölükbasi N, Yalcin S. The comparison of two techniques to increase the amount of peri-implant attached mucosa: free gingival grafts versus vestibuloplasty. One-year results from a randomised controlled trial. Eur J Oral Implantol. 2012;5:139-145.
    1. Basegmez C, Karabuda ZC, Demirel K, Yalcin S. The comparison of acellular dermal matrix allografts with free gingival grafts in the augmentation of peri-implant attached mucosa: a randomised controlled trial. Eur J Oral Implantol. 2013;6:145-152.
    1. Bianchi AE, Sanfilippo F. Single-tooth replacement by immediate implant and connective tissue graft: a 1-9-year clinical evaluation. Clin Oral Implants Res. 2004;15:269-277.
    1. Burkhardt R, Joss A, Lang NP. Soft tissue dehiscence coverage around endosseous implants: a prospective cohort study. Clin Oral Implants Res. 2008;19:451-457.
    1. Buyukozdemir Askin S, Berker E, Akincibay H, et al. Necessity of keratinized tissues for dental implants: a clinical, immunological, and radiographic study. Clin Implant Dent Relat Res. 2015;17:1-12.
    1. Cairo F, Barbato L, Tonelli P, Batalocco G, Pagavino G, Nieri M. Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled clinical trial. J Clin Periodontol. 2017;44:769-776.
    1. Covani U, Marconcini S, Galassini G, Cornelini R, Santini S, Barone A. Connective tissue graft used as a biologic barrier to cover an immediate implant. J Periodontol. 2007;78:1644-1649.
    1. D'Elia C, Baldini N, Cagidiaco EF, Nofri G, Goracci C, de Sanctis M. Peri-implant soft tissue stability after single implant restorations using either guided bone regeneration or a connective tissue graft: a randomized clinical trial. Int J Periodontics Restorative Dent. 2017;37:413-421.
    1. De Bruyckere T, Eeckhout C, Eghbali A, et al. A randomized controlled study comparing guided bone regeneration with connective tissue graft to re-establish convexity at the buccal aspect of single implants: a one-year CBCT analysis. J Clin Periodontol. 2018;45:1375-1387.
    1. De Bruyckere T, Eghbali A, Younes F, De Bruyn H, Cosyn J. Horizontal stability of connective tissue grafts at the buccal aspect of single implants: a 1-year prospective case series. J Clin Periodontol. 2015;42:876-882.
    1. Eghbali A, De Bruyn H, Cosyn J, Kerckaert I, Van Hoof T. Ultrasonic assessment of mucosal thickness around implants: validity, reproducibility, and stability of connective tissue grafts at the buccal aspect. Clin Implant Dent Relat Res. 2016;18:51-61.
    1. Eghbali A, Seyssens L, De Bruyckere T, Younes F, Cleymaet R, Cosyn J. A 5-year prospective study on the clinical and aesthetic outcomes of alveolar ridge preservation and connective tissue graft at the buccal aspect of single implants. J Clin Periodontol. 2018;45:1475-1484.
    1. Fenner N, Hammerle CH, Sailer I, Jung RE. Long-term clinical, technical, and esthetic outcomes of all-ceramic vs. titanium abutments on implant supporting single-tooth reconstructions after at least 5 years. Clin Oral Implants Res. 2016;27:716-723.
    1. Froum SJ, Khouly I, Tarnow DP, et al. The use of a xenogeneic collagen matrix at the time of implant placement to increase the volume of buccal soft tissue. Int J Periodontics Restorative Dent. 2015;35:179-189.
    1. Hanser T, Khoury F. Alveolar ridge contouring with free connective tissue graft at implant placement: a 5-year consecutive clinical study. Int J Periodontics Restorative Dent. 2016;36:465-473.
    1. Huber S, Zeltner M, Hämmerle CHF, Jung RE, Thoma DS. Non-interventional 1-year follow-up study of peri-implant soft tissues following previous soft tissue augmentation and crown insertion in single-tooth gaps. J Clin Periodontol. 2018;45:504-512.
    1. Hutton CG, Johnson GK, Barwacz CA, Allareddy V, Avila-Ortiz G. Comparison of two different surgical approaches to increase peri-implant mucosal thickness: a randomized controlled clinical trial. J Periodontol. 2018;89:807-814.
    1. Lee KH, Kim BO, Jang HS. Clinical evaluation of a collagen matrix to enhance the width of keratinized gingiva around dental implants. J Periodontal Implant Sci. 2010;40:96-101.
    1. Linkevicius T, Puisys A, Linkeviciene L, Peciuliene V, Schlee M. Crestal bone stability around implants with horizontally matching connection after soft tissue thickening: a prospective clinical trial. Clin Implant Dent Relat Res. 2015;17:497-508.
    1. Lorenzo R, Garcia V, Orsini M, Martin C, Sanz M. Clinical efficacy of a xenogeneic collagen matrix in augmenting keratinized mucosa around implants: a randomized controlled prospective clinical trial. Clin Oral Implants Res. 2012;23:316-324.
    1. Oh SL, Masri RM, Williams DA, Ji C, Romberg E. Free gingival grafts for implants exhibiting lack of keratinized mucosa: a prospective controlled randomized clinical study. J Clin Periodontol. 2017;44:195-203.
    1. Papi P, Di Murro B, Pompa G. Use of a xenogenic collagen membrane in peri-implant soft tissue augmentation. Dent Cadmos. 2019;87:150-157.
    1. Papi P, Pompa G. The use of a novel porcine derived acellular dermal matrix (mucoderm) in peri-implant soft tissue augmentation: preliminary results of a prospective pilot cohort study. Biomed Res Int. 2018;2018.
    1. Park JB. Increasing the width of keratinized mucosa around endosseous implant using acellular dermal matrix allograft. Implant Dent. 2006;15:275-281.
    1. Poli PP, Maridati PC, Stoffella E, Beretta M, Maiorana C. Influence of timing on the horizontal stability of connective tissue grafts for buccal soft tissue augmentation at single implants: a prospective controlled pilot study. J Oral Maxillofac Surg. 2019;77(6):1170-1179.
    1. Puisys A, Vindasiute E, Linkevciene L, Linkevicius T. The use of acellular dermal matrix membrane for vertical soft tissue augmentation during submerged implant placement: a case series. Clin Oral Implants Res. 2015;26:465-470.
    1. Puzio M, Błaszczyszyn A, Hadzik J, Dominiak M. Ultrasound assessment of soft tissue augmentation around implants in the aesthetic zone using a connective tissue graft and xenogeneic collagen matrix - 1-year randomised follow-up. Ann Anat. 2018;217:129-141.
    1. Qiao M, Zhang K, Dong J, Xu BH. Clinical study of the effect of free gingival graft and apically repositioned flap surgery on peri-implant keratinized gingival augmentation. Zhonghua Kou Qiang Yi Xue Za Zhi. 2016;51:605-609.
    1. Rojo E, Stroppa G, Sanz-Martin I, Gonzalez-Martín O, Alemany AS, Nart J. Soft tissue volume gain around dental implants using autogenous subepithelial connective tissue grafts harvested from the lateral palate or tuberosity area. A randomized controlled clinical study. J Clin Periodontol. 2018;45:495-503.
    1. Sanz M, Lorenzo R, Aranda JJ, Martin C, Orsini M. Clinical evaluation of a new collagen matrix (Mucograft® prototype) to enhance the width of keratinized tissue in patients with fixed prosthetic restorations: a randomized prospective clinical trial. J Clin Periodontol. 2009;36:868-876.
    1. Schallhorn RA, McClain PK, Charles A, Clem D, Newman MG. Evaluation of a porcine collagen matrix used to augment keratinized tissue and increase soft tissue thickness around existing dental implants. Int J Periodontics Restorative Dent. 2015;35:99-103.
    1. Schmitt CM, Moest T, Lutz R, Wehrhan F, Neukam FW, Schlegel KA. Long-term outcomes after vestibuloplasty with a porcine collagen matrix (Mucograft®) versus the free gingival graft: a comparative prospective clinical trial. Clin Oral Implants Res. 2016;27:e125-e133.
    1. Schmitt CM, Tudor C, Kiener K, et al. Vestibuloplasty: porcine collagen matrix versus free gingival graft: a clinical and histologic study. J Periodontol. 2013;84:914-923.
    1. Stefanini M, Felice P, Mazzotti C, Marzadori M, Gherlone EF, Zucchelli G. Transmucosal implant placement with submarginal connective tissue graft in area of shallow buccal bone dehiscence: a three-year follow-up case series. Int J Periodontics Restorative Dent. 2016;36:621-630.
    1. Stimmelmayr M, Stangl M, Edelhoff D, Beuer F. Clinical prospective study of a modified technique to extend the keratinized gingiva around implants in combination with ridge augmentation: one-year results. Int J Oral Maxillofac Implants. 2011;26:1094-1101.
    1. Thoma DS, Zeltner M, Hilbe M, Hammerle CH, Husler J, Jung RE. Randomized controlled clinical study evaluating effectiveness and safety of a volume-stable collagen matrix compared to autogenous connective tissue grafts for soft tissue augmentation at implant sites. J Clin Periodontol. 2016;43:874-885.
    1. Vellis J, Kutkut A, Al-Sabbagh M. Comparison of xenogeneic collagen matrix vs. free gingival grafts to increase the zone of keratinized mucosa around functioning implants. Implant Dent. 2019;28:20-27.
    1. Wiesner G, Esposito M, Worthington H, Schlee M. Connective tissue grafts for thickening peri-implant tissues at implant placement. One-year results from an explanatory split-mouth randomised controlled clinical trial. Eur J Oral Implantol. 2010;3:27-35.
    1. Zafiropoulos GG, John G. Use of collagen matrix for augmentation of the peri-implant soft tissue at the time of immediate implant placement. J Contemp Dent. 2017;18:386-391.
    1. Zeltner M, Jung RE, Hammerle CH, Husler J, Thoma DS. Randomized controlled clinical study comparing a volume-stable collagen matrix to autogenous connective tissue grafts for soft tissue augmentation at implant sites: linear volumetric soft tissue changes up to 3 months. J Clin Periodontol. 2017;44:446-453.
    1. Zucchelli G, Mazzotti C, Mounssif I, Mele M, Stefanini M, Montebugnoli L. A novel surgical-prosthetic approach for soft tissue dehiscence coverage around single implant. Clin Oral Implants Res. 2013;24:957-962.
    1. Oh SL, Ji C, Azad S. Free gingival grafts for implants exhibiting a lack of keratinized mucosa: extended follow-up of a randomized controlled trial. J Clin Periodontol. 2020;47:777-785.
    1. Puzio M, Hadzik J, Blaszczyszyn A, Gedrange T, Dominiak M. Soft tissue augmentation around dental implants with connective tissue graft (CTG) and xenogenic collagen matrix (XCM). 1-year randomized control trail. Ann Anat. 2020:151484.
    1. Thoma DS, Gasser TJW, Jung RE, Hammerle CHF. Randomized controlled clinical trial comparing implant sites augmented with a volume-stable collagen matrix or an autogenous connective tissue graft: 3-year data after insertion of reconstructions. J Clin Periodontol. 2020;47:630-639.
    1. Fischer KR, Testori T, Wachtel H, Muhlemann S, Happe A, Del Fabbro M. Soft tissue augmentation applying a collagenated porcine dermal matrix during second stage surgery: a prospective multicenter case series. Clin Implant Dent Relat Res. 2019;21:923-930.
    1. Ustaoglu G, Paksoy T, Gumus KC. Titanium-prepared platelet-rich fibrin versus connective tissue graft on peri-implant soft tissue thickening and keratinized mucosa width: a randomized, controlled trial. J Oral Maxillofac Surg. 2020;78:1112-1123.
    1. Verardi S, Orsini M, Lombardi T, et al. Comparison between two different techniques for peri-implant soft tissue augmentation: porcine dermal matrix graft versus tenting screw. J Periodontol. 2019. .
    1. Yu SH, Tseng SC, Wang HL. Classification of soft tissue grafting materials based on biologic principles. Int J Periodontics Restorative Dent. 2018;38:849-854.
    1. Sculean A, Gruber R, Bosshardt DD. Soft tissue wound healing around teeth and dental implants. J Clin Periodontol. 2014;41(Suppl 15):S6-22.
    1. Sculean A, Chappuis V, Cosgarea R. Coverage of mucosal recessions at dental implants. Periodontol 2000. 2017;73:134-140.
    1. Boynuegri D, Nemli SK, Kasko YA. Significance of keratinized mucosa around dental implants: a prospective comparative study. Clin Oral Implants Res. 2013;24:928-933.
    1. Stefanini M, Marzadori M, Tavelli L, Bellone P, Zucchelli G. Peri-implant papillae reconstruction at an esthetically failing implant. Int J Periodontics Restorative Dent. 2020;40:213-222.
    1. Tavelli L, Barootchi S, Di Gianfilippo R, et al. Acellular dermal matrix and coronally advanced flap or tunnel technique in the treatment of multiple adjacent gingival recessions. A 12-year follow-up from a randomized clinical trial. J Clin Periodontol. 2019;46:937-948.
    1. Bohac M, Danisovic L, Koller J, Dragunova J, Varga I. What happens to an acellular dermal matrix after implantation in the human body? A histological and electron microscopic study. Eur J Histochem. 2018;62:2873.
    1. Ahmedbeyli C, Ipci SD, Cakar G, Kuru BE, Yilmaz S. Clinical evaluation of coronally advanced flap with or without acellular dermal matrix graft on complete defect coverage for the treatment of multiple gingival recessions with thin tissue biotype. J Clin Periodontol. 2014;41:303-310.
    1. de Queiroz Cortes A, Sallum AW, Casati MZ, Nociti FH, Jr, Sallum EA. A two-year prospective study of coronally positioned flap with or without acellular dermal matrix graft. J Clin Periodontol. 2006;33:683-689.
    1. Paolantonio M, Dolci M, Esposito P, et al. Subpedicle acellular dermal matrix graft and autogenous connective tissue graft in the treatment of gingival recessions: a comparative 1-year clinical study. J Periodontol. 2002;73:1299-1307.

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