High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction

Zhaoyue Shi, Khue Tran, Christof Karmonik, Timothy Boone, Rose Khavari, Zhaoyue Shi, Khue Tran, Christof Karmonik, Timothy Boone, Rose Khavari

Abstract

Background: Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potential alternative. The purpose of this study is to evaluate the feasibility of utilizing resting states as a non-invasive alternative for investigating the bladder-related networks in the brain.

Methods: We quantitatively compared FC in brain regions belonging to the bladder-related network during the following states: 'strong desire to void', 'voiding initiation (or attempt at voiding initiation)', and 'voiding (or continued attempt of voiding)' with FC during rest in nine multiple sclerosis women with voiding dysfunction using fMRI data acquired at 7 T and 3 T.

Results: The inter-subject correlation analysis showed that voiding (or continued attempt of voiding) is achieved through similar network connections in all subjects. The task-based bladder-related network closely resembles the resting-state intrinsic network only during voiding (or continued attempt of voiding) process but not at other states.

Conclusion: Resting states fMRI can be potentially utilized to accurately reflect the voiding (or continued attempt of voiding) network. Concurrent UDS testing is still necessary for studying the effects of strong desire to void and initiation of voiding (or attempt at initiation of voiding).

Keywords: Brain connectivity; Functional magnetic resonance imaging; Multiple sclerosis; Resting states; Urodynamics; Voiding dysfunction.

Conflict of interest statement

The authors declare that they have no conflict of interest.

© 2021. The Author(s).

Figures

Fig. 1
Fig. 1
a Averaged functional connectivity matrices of all 13 ROIs for 9 subjects in the following three urodynamic phases ‘strong desire to void’, ‘initiation of voiding (or attempt at initiation of voiding)’, ‘voiding (or continued attempt of voiding)’, and resting states. The row and column represent each ROI number and their corresponding brain regions can be seen in Table 1. The color bar represents correlation values ranging from -1 to 1. b Group analysis of inter-subject correlations in functional connectivity within 13 ROIs across 9 subjects during three urodynamic phases and resting states, respectively. c The boxplot shows a group analysis of correlations within the bladder-related network between resting states and three urodynamic phases, respectively.

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