Effects of topical dexamethasone in postoperative sore throat

Jeong Han Lee, Soo Bin Kim, Wonjin Lee, Seunghee Ki, Myoung-Hun Kim, Kwangrae Cho, Se Hun Lim, Kun Moo Lee, Deul-Nyuck Choi, Minkyung Oh, Jeong Han Lee, Soo Bin Kim, Wonjin Lee, Seunghee Ki, Myoung-Hun Kim, Kwangrae Cho, Se Hun Lim, Kun Moo Lee, Deul-Nyuck Choi, Minkyung Oh

Abstract

Background: Postoperative sore throat (POST) is a complication that undermines patient satisfaction and increases discomfort in the postoperative period. The present study examined the effects of dexamethasone gargle and endotracheal tube cuff soaking on the incidence and severity of POST.

Methods: Ninety patients undergoing laparoscopic cholecystectomy were randomly allocated into three groups: 0.9% normal saline gargling and tube soaking (group C), 0.05% dexamethasone solution gargling and 0.9% normal saline tube soaking (group G), 0.9% normal saline gargling and 0.05% dexamethasone tube soaking (group S). The incidence and severity of POST were then assessed and recorded at 24 hours after surgery.

Results: The total incidence of POST was significantly different among the groups (P < 0.05), and group S exhibited a significantly lower incidence of POST than group C (P < 0.0167). In addition, the POST intensity of group G and group S was less severe than those of group C (Both P < 0.0167).

Conclusions: Among patients undergoing laparoscopic cholecystectomy, those who gargled with 0.05% dexamethasone solution exhibited lower severity of POST than the control group, and those whose endotracheal tube cuff was soaked in the dexamethasone solution before intubation exhibited significantly lower incidence and severity of POST than the control group.

Keywords: Dexamethasone; Intratracheal intubation; Laparoscopic cholecystectomy; Pharyngitis; Postoperative complication.

Figures

Fig. 1. Flow diagram of study enrollment.…
Fig. 1. Flow diagram of study enrollment. ASA: American Society of Anesthesiologists, POST: postoperative sore throat, URI: upper respiratory tract infection, ENBD: endoscopic nasobiliary drainage.

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