Oseltamivir resistance during treatment of influenza A (H5N1) infection
Menno D de Jong, Tan Thanh Tran, Huu Khanh Truong, Minh Hien Vo, Gavin J D Smith, Vinh Chau Nguyen, Van Cam Bach, Tu Qui Phan, Quang Ha Do, Yi Guan, J S Malik Peiris, Tinh Hien Tran, Jeremy Farrar, Menno D de Jong, Tan Thanh Tran, Huu Khanh Truong, Minh Hien Vo, Gavin J D Smith, Vinh Chau Nguyen, Van Cam Bach, Tu Qui Phan, Quang Ha Do, Yi Guan, J S Malik Peiris, Tinh Hien Tran, Jeremy Farrar
Abstract
Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) virus infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. These observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents.
Copyright 2005 Massachusetts Medical Society.
Source: PubMed