The NIH Roadmap Epigenomics Mapping Consortium

Bradley E Bernstein, John A Stamatoyannopoulos, Joseph F Costello, Bing Ren, Aleksandar Milosavljevic, Alexander Meissner, Manolis Kellis, Marco A Marra, Arthur L Beaudet, Joseph R Ecker, Peggy J Farnham, Martin Hirst, Eric S Lander, Tarjei S Mikkelsen, James A Thomson, Bradley E Bernstein, John A Stamatoyannopoulos, Joseph F Costello, Bing Ren, Aleksandar Milosavljevic, Alexander Meissner, Manolis Kellis, Marco A Marra, Arthur L Beaudet, Joseph R Ecker, Peggy J Farnham, Martin Hirst, Eric S Lander, Tarjei S Mikkelsen, James A Thomson

Abstract

The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease.

Figures

Figure 1
Figure 1
Layers of genome organization. Genome function and cellular phenotypes are influenced by DNA methylation and the protein-DNA complex known as chromatin. In mammals, DNA methylation occurs on cytosine bases, primarily in the context of CpG dinucleotides. Accessible chromatin that is hypersensitive to DNase I digestion marks promoters and functional elements bound by transcription factors or other regulatory proteins. Histone modifications, associated proteins such as Polycomb repressors and noncoding RNAs constitute an additional layer of chromatin structure that affects genome function in a context-dependent manner.
Figure 2
Figure 2
Portal for the NIH Roadmap Epigenomics Mapping Consortium. A public portal (http://www.roadmapepigenomics.org/) provides general information about the consortium and its participants, along with links to experimental protocols, consortium data and interfaces for visualizing epigenomic maps.

Source: PubMed

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