Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults

Abstract

Background & aims: The impact of vitamin D supplementation in overweight and obese adults during resistance training on body composition, muscle function, and glucose tolerance was investigated.

Methods: Twenty-three overweight and obese (age: 26.1±4.7 y; BMI: 31.3±3.2 kg/m(2); 25-hydroxyvitamin D: 19.3±7.2 ng/mL) adults were recruited for participation in a double-blind, placebo-controlled trial. Participants were randomly divided into vitamin D (VitD, 4000 IU/d; 5 females, 5 males) and placebo (PL; 7 females, 6 males) groups. Both groups completed 12 weeks of resistance training. 25-hydroxyvitamin D, parathyroid hormone, body composition, and glucose tolerance were assessed at baseline and 12 weeks. Muscle function (strength and power) was assessed at baseline, 4, 8, and 12 weeks.

Results: During the intervention, 25-hydroxyvitamin D increased and parathyroid hormone decreased in the VitD group (P<0.05). Peak power was significantly increased at 4 weeks in the VitD group only (P<0.05). Regression analysis revealed an inverse association between the change in 25-hydroxyvitamin D with the change in waist-to-hip ratio (R(2)=0.205, P=0.02). No other improvements were observed with supplementation.

Conclusions: Vitamin D supplementation in overweight and obese adults during resistance training induced an early improvement in peak power, and elevated vitamin D status was associated with reduced waist-to-hip ratio.

Clinical trial registration number: NCT01199926.

Conflict of interest statement

Conflict of Interest

The authors report no conflict of interest.

Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Figures

Figure 1

Absolute change (from baseline) in lean mass and fat mass after the 12 week resistance exercise intervention. All values are mean ± SEM’s. Placebo (□) and vitamin D (■) groups.

Figure 2

Correlation between the change in waist-to-hip ratio and the change in serum 25OHD at 12 weeks. A significant correlation between change (12 week-baseline) in waist-to-hip ratio and change in serum 25OHD was shown (simple linear regression R2 = 0.205, F (1, 21) = 5.40, P = 0.02). Placebo (○) and vitamin D (●) groups.

Figure 3

Change from baseline in peak power. All values are mean ± SEM’s. The (a) indicates a significant increase from baseline, P