Environmental monitoring of secondhand smoke exposure

Benjamin J Apelberg, Lisa M Hepp, Erika Avila-Tang, Lara Gundel, S Katharine Hammond, Melbourne F Hovell, Andrew Hyland, Neil E Klepeis, Camille C Madsen, Ana Navas-Acien, James Repace, Jonathan M Samet, Patrick N Breysse, Benjamin J Apelberg, Lisa M Hepp, Erika Avila-Tang, Lara Gundel, S Katharine Hammond, Melbourne F Hovell, Andrew Hyland, Neil E Klepeis, Camille C Madsen, Ana Navas-Acien, James Repace, Jonathan M Samet, Patrick N Breysse

Abstract

The complex composition of secondhand smoke (SHS) provides a range of constituents that can be measured in environmental samples (air, dust and on surfaces) and therefore used to assess non-smokers' exposure to tobacco smoke. Monitoring SHS exposure (SHSe) in indoor environments provides useful information on the extent and consequences of SHSe, implementing and evaluating tobacco control programmes and behavioural interventions, and estimating overall burden of disease caused by SHSe. The most widely used markers have been vapour-phase nicotine and respirable particulate matter (PM). Numerous other environmental analytes of SHS have been measured in the air including carbon monoxide, 3-ethenylpyridine, polycyclic aromatic hydrocarbons, tobacco-specific nitrosamines, nitrogen oxides, aldehydes and volatile organic compounds, as well as nicotine in dust and on surfaces. The measurement of nicotine in the air has the advantage of reflecting the presence of tobacco smoke. While PM measurements are not as specific, they can be taken continuously, allowing for assessment of exposure and its variation over time. In general, when nicotine and PM are measured in the same setting using a common sampling period, an increase in nicotine concentration of 1 μg/m(3) corresponds to an average increase of 10 μg/m3 of PM. This topic assessment presents a comprehensive summary of SHSe monitoring approaches using environmental markers and discusses the strengths and weaknesses of these methods and approaches.

Conflict of interest statement

Competing interests: None.

References

    1. Lofroth G. Environmental tobacco smoke: overview of chemical composition and Genotoxic components. Mutat Res 1989;222:73–80
    1. National Research Council Environmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects. 3rd edn Washington, D.C.: National Academy Press; 1986
    1. Repace JL, Lowrey AH. Indoor air pollution, tobacco smoke and public health. Science 1980;208:464–74
    1. Spengler JD, Ferris BG., Jr Harvard air pollution health study in Six Cities in the U.S.A. Tokai J Exp Clin Med 1985;10:263–86
    1. Hammond SK, Leaderer BP. A diffusion monitor to measure exposure to passive smoking. Environ Sci Technol 1987;21:494–7
    1. Schlotzhauer SW, Chortyk OT. Effects of varied smoking machine parameters on deliveries of total particulate matter and selected smoke constituents from an ultra low-tar cigarette. J Anal Toxicol 1983;7:92–5
    1. Rickert WS, Robinson JC, Collishaw N. Yields of tar, nicotine, and carbon monoxide in the sidestream smoke from 15 brands of Canadian cigarettes. Am J Public Health 1984;74:228–31
    1. United States Department of Health and Human Services The Health Consequences Of Involuntary Exposure To Tobacco Smoke: A Report Of The Surgeon General. Washington D.C: U.S Govt Printing Off, 2006
    1. Gorini G, Gasparrini A, Fondelli MC, et al. Secondhand Smoke (SHS) Markers: Review of Methods For Monitoring Exposure Levels. Belgium: Eur Netw Smoking Prev, 2005
    1. Jaakkola MS, Jaakkola JJ. Assessment of exposure to environmental tobacco smoke. Eur Respir J 1997;10:2384–97
    1. Ott WR. Mathematical models for predicting indoor air quality from smoking activity. Environ Health Perspect 1999;107(Suppl 2):375–81
    1. Repace J. Respirable particles and carcinogens in the air of delaware hospitality venues before and after a smoking ban. J Occup Environ Med 2004;46:887–905
    1. Repace JL, Lowrey AH. An Enforceable indoor air quality standard for environmental tobacco smoke in the workplace. Risk Anal 1993;13:463–75
    1. Klepeis NE, Ott WR, Switzer P. Real-time measurement of outdoor tobacco smoke particles. J Air Waste Manag Assoc 2007;57:522–34
    1. Ott WR, Klepeis NE, Switzer P. Air change rates of motor vehicles and in-vehicle pollutant concentrations from secondhand smoke. J Expo Sci Environ Epidemiol 2008;18:312–25
    1. Klepeis NE, Nazaroff WW. Modeling residential exposure to secondhand tobacco smoke. Atmos Environ 2006;40:4393–407
    1. Ott WR, Klepeis NE, Switzer P. Analytical solutions to compartmental indoor air quality models with application to environmental tobacco smoke concentrations measured in a house. J Air Waste Manag Assoc 2003;53:918–36
    1. McBride SJ, Ferro AR, Ott WR, et al. Investigations of the proximity effect for pollutants in the indoor environment. J Expo Anal Environ Epidemiol 1999;9:602–21
    1. Ferro AR. Effect of interior door position on room-to-room differences in residential pollutant concentrations after short term releases. Atmos Environ 2009;43:706
    1. Miller SL, Branoff S, Nazaroff WW. Exposure to toxic air contaminants in environmental tobacco smoke: an assessment for California based on personal monitoring data. J Expo Anal Environ Epidemiol 1998;8:287–311
    1. Klepeis NR, Ott WR, Switzer P. A multiple-smoker model for predicting indoor air quality in public lounges. Environ Sci Technol 1996;30:2813–20
    1. Klepeis NE, Ott WR, Repace JL. The effect of cigar smoking on indoor levels of carbon monoxide and particles. J Expo Anal Environ Epidemiol 1999;9:622–35
    1. Repace JL. Exposure to secondhand smoke. In: Ott WR, Steinenmann AC, Wallace LA, eds. Exposure Analysis. Boca Raton: CRC Press, 2007:201–36
    1. Ott WR. Mathematical modeling of indoor air quality. In: Ott WR, Steinenmann AC, Wallace LA, eds. Exposure Analysis. Boca Raton: CRC Press, 2006:411–44
    1. Ott WR, Steinenmann AC, Wallace LA. Exposure Analysis. Boca Raton: CRC Press, 2006
    1. Repace J, Al-Delaimy WK, Bernert JT. Correlating atmospheric and biological markers in studies of secondhand tobacco smoke exposure and dose in children and adults. J Occup Environ Med 2006;48:181–94
    1. Repace J. Controlling tobacco smoke pollution. ASHRAE IAQ 2005;6:11–15
    1. Repace JL, Lowrey AH. A quantative estimate of nonsmokers' lung cancer risk from passive smoking. Environ Int 1985;11:3–22
    1. Hedge A, Erickson WA, Rubin G. The effects of alternative smoking policies on indoor air quality in 27 office buildings. Ann Occup Hyg 1994;38:265–78
    1. Hyvarinen MJ, Rothberg M, Kahkonen E, et al. Nicotine and 3-ethenylpyridine concentrations as markers for environmental tobacco smoke in restaurants. Indoor Air 2000;10:121–5
    1. Sterling TD, Mueller B. Concentrations of nicotine, RSP, CO and CO2 in nonsmoking areas of offices ventilated by air recirculated from smoking designated areas. Am Ind Hyg Assoc J 1988;49:423–6
    1. Weber A, Fischer T. Passive smoking at work. Int Arch Occup Environ Health 1980;47:209–21
    1. Muramatsu M, Umemura S, Okada T, et al. Estimation of personal exposure to tobacco smoke with a newly developed nicotine personal monitor. Environ Res 1984;35:218–27
    1. Bolte G, Heitmann D, Kiranoglu M, et al. Exposure to environmental tobacco smoke in German restaurants, pubs and discotheques. J Expo Sci Environ Epidemiol 2008;18:262–71
    1. Leaderer BP, Hammond SK. Evaluation of vapour-phase nicotine and respirable suspended particle mass as markers for environmental tobacco smoke. Environ Sci Technol 1991;25:770–7
    1. Muramatsu T, Weber A, Muramatsu S, et al. An experimental study on irritation and annoyance due to passive smoking. Int Arch Occup Environ Health 1983;51:305–17
    1. Ott WR, Switzer P, Robinson J. Particle concentrations inside a tavern before and after prohibition of smoking: evaluating the performance of an indoor air quality model. J Air Waste Manag Assoc 1996;46:1120–34
    1. Waring MS, Siegel JA. An evaluation of the indoor air quality in bars before and after a smoking Ban in Austin, Texas. J Expo Sci Environ Epidemiol 2007;17:260–8
    1. Wang JN, Zhang Y. CO and particle pollution of indoor air in Beijing and its elemental analysis. Biomed Environ Sci 1990;3:132–8
    1. Olander L, Johansson J, Johansson R. Tobacco smoke removal with room air cleaners. Scand J Work Environ Health 1988;14:390–7
    1. Bohanon HR, Jr, Piade JJ, Schorp MK, et al. An international survey of indoor air quality, ventilation, and smoking activity in restaurants: a pilot study. J Expo Anal Environ Epidemiol 2003;13:378–92
    1. Jenkins RA, Maskarinec MP, Counts RW, et al. Environmental tobacco smoke in an unrestricted smoking workplace: area and personal exposure monitoring. J Expo Anal Environ Epidemiol 2001;11:369–80
    1. Jenkins RA, Palausky MA, Counts RW, et al. Determination of personal exposure of non-smokers to environmental tobacco smoke in the United States. Lung cancer 1996;14 (Suppl 1):S195–213
    1. Johnsson T, Tuomi T, Riuttala H, et al. Environmental tobacco smoke in Finnish restaurants and bars before and after smoking restrictions were introduced. Ann Occup Hyg 2006;50:331–41
    1. Kuusimaki L, Peltonen K, Vainiotalo S. Assessment of environmental tobacco smoke exposure of Finnish restaurant workers, using 3-ethenylpyridine as marker. Indoor Air 2007;17:394–403
    1. Maskarinec MP, Jenkins RA, Counts RW, et al. Determination of exposure to environmental tobacco smoke in restaurant and Tavern Workers in one US City. J Expo Anal Environ Epidemiol 2000;10:36–49
    1. Phillips K, Bentley MC, Howard DA, et al. Assessment of environmental tobacco smoke and respirable suspended particle exposures for nonsmokers in prague using personal monitoring. Int Arch Occup Environ Health 1998;71:379–90
    1. Phillips K, Howard DA, Bentley MC, et al. Measured exposures by personal monitoring for respirable suspended particles and environmental tobacco smoke of housewives and office workers resident in Bremen, Germany. Int Arch Occup Environ Health 1998;71:201–12
    1. Phillips K, Bentley MC. Seasonal assessment of environmental tobacco smoke and respirable suspended particle exposures for nonsmokers in Bremen using personal monitoring. Environ Int 2001;27:69–85
    1. Vainiotalo S, Vaaranrinta R, Tornaeus J, et al. Passive monitoring method for 3-Ethenylpyridine: a marker for environmental tobacco smoke. Environ Sci Technol 2001;35:1818–22
    1. Triebig G, Zober MA. Indoor air pollution by smoke constituents–a survey. Prev Med 1984;13:570–81
    1. Lung SC, Wu MJ, Lin CC. Customers' exposure to PM2.5 and polycyclic aromatic hydrocarbons in smoking/nonsmoking sections of 24-h coffee shops in Taiwan. J Expo Anal Environ Epidemiol 2004;14:529–35
    1. Siwinska E, Mielzynska D, Bubak A, et al. The effect of coal Stoves and environmental tobacco smoke on the level of urinary 1-hydroxypyrene. Mutat Res 1999;445:147–53
    1. Besaratinia A, Maas LM, Brouwer EM, et al. A molecular dosimetry approach to assess human exposure to environmental tobacco smoke in pubs. Carcinogenesis 2002;23:1171–6
    1. Chuang JC, Callahan PJ, Lyu CW, et al. Polycyclic aromatic hydrocarbon exposures of children in low-income families. J Expo Anal Environ Epidemiol 1999;9:85–98
    1. Fromme H, Dietrich S, Heitmann D, et al. Indoor air contamination during a waterpipe (narghile) smoking session. Food Chem Toxicol 2009;47:1636–41
    1. Saborit JM, Aquilina NJ, Meddings C, et al. Measurement of personal exposure to volatile organic compounds and particle associated PAH in three UK regions. Environ Sci Technol 2009;43:4582–8
    1. Choi H, Perera F, Pac A, et al. Estimating individual-level exposure to airborne polycyclic aromatic hydrocarbons throughout the gestational period based on personal, indoor, and outdoor monitoring. Environ Health Perspect 2008;116:1509–18
    1. Daher N, Saleh R, Jaroudi E, et al. Comparison of carcinogen, carbon monoxide, and ultrafine particle emissions from Narghile waterpipe and cigarette smoking: sidestream smoke measurements and assessment of second-hand smoke emission factors. Atmos Environ 2010;44:8–14
    1. Brunnemann KD, Cox JE, Hoffmann D. Analysis of tobacco-specific N-Nitrosamines in indoor air. Carcinogenesis 1992;13:2415–18
    1. Scherer G, von MC, von ML, et al. Biomonitoring after controlled exposure to environmental tobacco smoke (ETS). Exp Pathol 1989;37:158–63
    1. Schick SF, Glantz S. Concentrations of the carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research. Cancer Epidemiol Biomark Prev 2007;16:1547–53
    1. Thompson BT, Mizaikoff B. Real-time fourier transform-infrared analysis of carbon monoxide and nitric oxide in sidestream cigarette smoke. Appl Spectrosc 2006;60:272–8
    1. Vainiotalo S, Vaananen V, Vaaranrinta R. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke. Environ Res 2008;108:280–8
    1. Weber A. Annoyance and irritation by passive smoking. Prev Med 1984;13:618–25
    1. Hugod C. Indoor air pollution with smoke constituents–an experimental investigation. Prev Med 1984;13:582–8
    1. Kim S, Aung T, Berkeley E, et al. Measurement of nicotine in household dust. Environ Res 2008;108:289–93
    1. Diette GB, Hansel NN, Buckley TJ, et al. Home indoor pollutant exposures among inner-city children with and without asthma. Environ Health Perspect 2007;115:1665–9
    1. Breysse PN, Buckley TJ, Williams D, et al. Indoor exposures to air pollutants and allergens in the homes of asthmatic children in inner-city Baltimore. Environ Res 2005;98:167–76
    1. Willers S, Hein HO, Jansson L. Assessment of environmental tobacco smoke exposure: urinary cotinine concentrations in children are strongly associated with the house dust concentrations of nicotine at home. Indoor Air 2004;14:83–6
    1. Whitehead T, Metayer C, Ward MH, et al. Is house-dust nicotine a good surrogate for household smoking? Am J Epidemiol 2009;169:1113–23
    1. Matt GE, Quintana PJ, Hovell MF, et al. Households contaminated by environmental tobacco smoke: sources of infant exposures. Tob Control 2004;13:29–37
    1. Matt GE, Quintana PJ, Hovell MF, et al. Residual tobacco smoke pollution in used cars for Sale: air, dust, and surfaces. Nicotine Tob Res 2008;10:1467–75
    1. Navas-Acien A, Peruga A, Breysse P, et al. Secondhand tobacco smoke in public places in Latin America, 2002-2003. JAMA 2004;291:2741–5
    1. Marbury MC, Hammond SK, Haley NJ. Measuring exposure to environmental tobacco smoke in studies of acute health effects. Am J Epidemiol 1993;137:1089–97
    1. Hammond SK. Exposure of U.S. workers to environmental tobacco smoke. Environ Health Perspect 1999;107(Suppl 2):329–40
    1. Jenkins RA, Guerin MR, Tomkins BA. The Chemistry Of Environmental Tobacco Smoke: Composition An Measurement. 2nd edn Boca Raton, Florida: Lewis Publishers, 2000
    1. Hammond SK. Evaluating exposure to environmental tobacco smoke. In: Winegar ED, Keith LH, eds. Sampling and Analysis of Airborne Pollutants. Boca Raton, Fl: Lewis Publishers, 1993:319–38
    1. Coultas DB, Samet JM, McCarthy JF, et al. Variability of measures of exposure to environmental tobacco smoke in the home. Am Rev Respir Dis 1990;142:602–6
    1. Guerin MR, Jenkins RA, Tomkins BA. The Chemistry Of Environmental Tobacco Smoke: Composition And Measurement. Chelsea, MI: Lewis Publishers, 1992:1–330
    1. Jones MR, Navas-Acien A, Yuan J, et al. Secondhand tobacco smoke concentrations in motor vehicles: a pilot study. Tob Control 2009;18:399–404
    1. Miesner EA, Rudnick SN, Hu FC, et al. Particulate and nicotine sampling in public facilities and offices. JAPCA 1989;39:1577–82
    1. Schenker MB, Vedal S, Baatterman S, et al. Health effects of air pollution due to coal combustion in the chestnut ridge region of Pennsylvania: cross-section survey of children. Arch Environ Health 1986;41:104–8
    1. Schenker MB, Samuels SJ, Kado NY, et al. Markers of Exposure to Diesel Exhaust in Railroad Workers. Capitol City Press. Montpelier, VT: Health Effects Institute, 1990. Report No.: 33.
    1. Schenker MB, Kado NY, Hammond SK, et al. Urinary mutagenic activity in workers exposed to diesel exhaust. Environ Res 1992;57:133–48
    1. Wipfli H, Avila-Tang E, Navas-Acien A, et al. Secondhand smoke exposure among women and children: evidence from 31 countries. Am J Public Health 2008;98:672–9
    1. Blanco-Marquizo A, Goja B, Peruga A, et al. Reduction of secondhand tobacco smoke in public places following National smoke-free legislation in Uruguay. Tob Control 2010;19:231–4
    1. Mulcahy M, Evans DS, Hammond SK, et al. Secondhand smoke exposure and risk following the Irish smoking ban: an assessment of salivary cotinine concentrations in hotel workers and air nicotine levels in bars. Tob Control 2005;14:384–8
    1. Edwards R, Thomson G, Wilson N, et al. After the smoke has cleared: evaluation of the impact of a new national smoke-free law in new Zealand. Tob Control 2008;17:e2.
    1. Fong GT, Cummings KM, Borland R, et al. The conceptual framework of the international tobacco control (ITC) policy evaluation project. Tob Control 2006;15(Suppl 3):iii3–11
    1. Agbenyikey W, Wellington E, Gyapong J, et al. Secondhand tobacco smoke exposure in selected public places (PM2.5 and air nicotine) and non-smoking employees (hair nicotine) in Ghana. Tob Control 2010;18:399–404
    1. Erazo M, Iglesias V, Droppelmann A, et al. Secondhand tobacco smoke in bars and restaurants in Santiago, Chile: evaluation of partial smoking ban legislation in public places. Tob Control 2010;19:469–74
    1. Gorini G. Impact of the Italian smoking ban and comparison with the evaluation of the Scottish ban. Epidemiol Prev 2011;35(3–4 Suppl. 1):4–18
    1. Kaur J, Vinayak P. Air nicotine monitoring for second hand smoke exposure in public places in India. Indian J Community Med 2011;36:98–103
    1. Nebot M, Lopez MJ, Ariza C, et al. Impact of the Spanish smoking law on exposure to secondhand smoke in offices and hospitality venues: before-and-after study. Environ Health Perspect 2009;117:344–7
    1. Connolly GN, Carpenter CM, Travers MJ, et al. How smoke-free laws improve air quality: a global study of Irish pubs. Nicotine Tob Res 2009;11:600–5
    1. Rees VW, Connolly GN. Measuring air quality to protect children from secondhand smoke in cars. Am J Prev Med 2006;31:363–8
    1. Sendzik T, Fong GT, Travers MJ, et al. An experimental investigation of tobacco smoke pollution in cars. Nicotine Tob Res 2009;11:627–34
    1. Nardini S, Cagnin R, Invernizzi G, et al. Indoor particulate matter measurement as a tool in the process of the implementation of smoke-free hospitals. Monaldi Arch Chest Dis 2004;61:183–92
    1. Avila-Tang E, Travers MJ, Navas-Acien A. Promoting smoke-free environments in Latin America: a comparison of methods to assess secondhand smoke exposure. Salud Publica Mex 2010;52(Suppl 2):S138–48
    1. Daly BJ, Schmid K, Riediker M. Contribution of fine particulate matter sources to indoor exposure in bars, restaurants, and cafes. Indoor Air 2010;20:204–12
    1. Repace JL, Hyde JN, Brugge D. Air pollution in Boston bars before and after a smoking ban. BMC Public Health 2006;6:266.
    1. Klepeis NE, Apte MG, Gundel LA, et al. Determining size-specific emission factors for environmental tobacco smoke particles. Aerosol Sci Technol 2003;37:780–90
    1. Institute of Medicine (IOM) Secondhand Smoke Exposure and Cardiovascular Effects: Making Sense of the Evidence. Committe on Secondhand Smoke Exposure and Acture Coronary Events. Washington DC: National Academy of Sciences, 2010
    1. World Health Organization WHO Air Quality Guidelines For Particulate Matter, Ozone, Nitrogen Dioxide, and Sulfur Dioxide. Global Update, 2005. Geneva, Switzerland: WHO Press, 2005
    1. U.S.Environmental Protection Agency Particulate Matter Standards. 2010.
    1. World Health Organization WHO Guidelines for Indoor Air Quality: Selected Pollutants. Bonn, Germany: in puncto druck+medien GmbH; 2010
    1. Pope CA, III, Burnett RT, Krewski D, et al. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation 2009;120:941–8
    1. Lee K, Hahn EJ, Pieper N, et al. Differential impacts of smoke-free laws on indoor air quality. J Environ Health 2008;70:24–30, 54.
    1. Sem GJ, Tsurubayashi K. A new mass sensor for respirable dust measurement. Am Ind Hyg Assoc J 1975;36:791–800
    1. Ramachandran G, Adgate JL, Pratt GC, et al. Characterizing indoor and outdoor 15 minute average PM[Sub2.5] concentrations in urban neighborhoods. Aerosol Sci Technol 2003;37:33
    1. Malm WC, Day DE, Kreidenweis SM. Light scattering characteristics of aerosols as a function of relative humidity: part I–a comparison of measured scattering and aerosol concentrations using the theoretical models. J Air Waste Manag Assoc 2000;50:686–700
    1. Akbar-Khanzadeh F, Greco TM. Health and social concerns of restaurant/bar workers exposed to environmental tobacco smoke. Med Lav 1996;87:122–32
    1. Aviado DM. Carbon monoxide as an index of environmental tobacco smoke exposure. Eur J Respir Dis 1984;133:47–60
    1. Jo WK, Oh JW, Dong JI. Evaluation of exposure to carbon monoxide associated with passive smoking. Environ Res 2004;94:309–18
    1. Repace JL, Ott WR, Klepeis NE. Indoor air pollution from cigar smoke. In: National Cancer Institute Smoking and Tobacco Control Monograph No. 9. Cigars- Health Effects and Trends. Bethesda, MD: National Institutes of Health, National Cancer Institute, 1998
    1. Bardana EJ, ed. Indoor Air Pollution and Health. New York: Marcel Dekker, Inc, 1996
    1. LaKind JS, Jenkins RA, Naiman DQ, et al. Use of environmental tobacco smoke constituents as markers for exposure. Risk Anal 1999;19:359–73
    1. Agency for Toxic Substances and Disease Registry Agency for Toxic Substances and Disease Registry (ATSDR), Public Health Statement for Polycyclic Aromatic Hydrocarbons (PAHs). Atlanta, GA: U.S Department of Health and Human Services, Public Health Service, 1995
    1. Repace JL, Jiang RT, Acevedo-Bolton V, et al. Fine particle air pollution and secondhand smoke exposures and risks inside 66 US Casinos. Environ Res 2011;111:473–84
    1. U.S.Environmental Protection Agency Methods for Organic Chemical Analysis of Municipal and Industrial Wastewater: Method 610- Polynuclear Aronmatic Hydorcarbons. 2010.
    1. Ott WR, Siegmann HC. Using multiple continous fine particle monitors to characterize tobacco, incense, candle, cooking, wood burning, and vehicular sources in indoor, outdoor, and in-transit settings. Atmos Environ 2006;40:821–43
    1. Repace JL. Secondhand smoke in Pennsylvania Casinos: a study of nonsmokers' exposure, dose, and risk. Am J Public Health 2009;99:1478–85
    1. Eisner MD, Jacob P, III, Benowitz NL, et al. Longer term exposure to secondhand smoke and health outcomes in COPD: impact of Urine 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol. Nicotine Tob Res 2009;11:945–53
    1. Hecht SS. Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. Carcinogenesis 2002;23:907–22
    1. Matt GE, Quintana PJ, Zakarian JM, et al. When smokers move out and non-smokers move in: residential thirdhand smoke pollution and exposure. Tob Control 2011;20:e1.
    1. Hein HO, Suadicani P, Skov P, et al. Indoor dust exposure: an unnoticed aspect of involuntary smoking. Arch Environ Health 1991;46:98–101
    1. Benton M, Chua MJ, Gu F, et al. Environmental nicotine contamination in latent fingermarks from smoker contacts and passive smoking. Forensic Sci Int 2010;200:28–34
    1. Sleiman M, Gundel LA, Pankow JF, et al. Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards. Proc Natl Acad Sci U S A 2010;107:6576–81
    1. Winickoff JP, Friebely J, Tanski SE, et al. Beliefs about the health effects of “Thirdhand” smoke and home smoking bans. Pediatrics 2009;123:e74–9
    1. Daisey JM. Tracers for assessing exposure to environmental tobacco smoke: what are they tracing? Environ health Perspect 1999;107(Suppl 2):319–27
    1. Ellingsen DG, Fladseth G, Daae HL, et al. Airborne exposure and biological monitoring of bar and restaurant workers before and after the introduction of a smoking ban. J Environ Monit 2006;8:362–8
    1. Chiu YH, Hart JE, Smith TJ, et al. Nicotine contamination in particulate matter sampling. Int J Environ Res Public Health 2009;6:601–7
    1. Butz AM, Breysse P, Rand C, et al. Household smoking behavior: effects on indoor air quality and health of urban children with asthma. Matern Child Health J 2011;15:460–8
    1. Coultas DB, Samet JM, McCarthy JF, et al. A personal monitoring study to assess workplace exposure to environmental tobacco smoke. Am J Public Health 1990;80:988–90
    1. Kado NY, McCurdy SA, Tesluk SJ, et al. Measuring personal exposure to airborne mutagens and nicotine in environmental tobacco smoke. Mutat Res 1991;261:75–82
    1. LaKind JS, Ginevan ME, Naiman DQ, et al. Distribution of exposure concentrations and doses for constituents of environmental tobacco smoke. Risk Anal 1999;19:375–90
    1. Rumchev K, Jamrozik K, Stick S, et al. How free of tobacco smoke are ‘smoke-free’ homes? Indoor Air 2008;18:202–8
    1. Thompson CV, Jenkins RA, Higgins CE. A thermal desorption method for the determination of nicotine in indoor environments. Environ Sci Technol 1989;23:429–35
    1. Van Loy MD, Riley WJ, Daisey JM, et al. Dynamic behavior of semivolatile organic compounds in indoor air. 2. Nicotine and phenanthrene with carpet and wallboard. Environ Sci Technol 2001;35:560–7
    1. Berman BA, Wong GC, Bastani R, et al. Household smoking behavior and ETS exposure among children with asthma in low-income, minority households. Addict Behav 2003;28:111–28
    1. O'Connor TZ, Holford TR, Leaderer BP, et al. Measurement of exposure to environmental tobacco smoke in pregnant women. Am J Epidemiol 1995;142:1315–21
    1. Coghlin J, Hammond SK, Gann PH. Development of epidemiologic tools for measuring environmental tobacco smoke exposure. Am J Epidemiol 1989;130:696–704
    1. Emerson JA, Hovell MF, Meltzer SB, et al. The accuracy of environmental tobacco smoke exposure measures among asthmatic children. J Clin Epidemiol 1995;48:1251–9
    1. Wallace LA. Indoor particles: a review. J Air Waste Manag Assoc 1996;46:98–126
    1. Ozkaynak H, Xue J, Spengler J, et al. Personal exposure to airborne particles and metals: results from the particle TEAM study in Riverside, California. J Expo Anal Environ Epidemiol 1996;6:57–78
    1. Hyland A, Travers MJ, Dresler C, et al. A 32-Country comparison of tobacco smoke derived particle levels in indoor public places. Tob Control 2008;17:159–65
    1. Brauer M, Mannetje A. Restaurant smoking restrictions and environmental tobacco smoke exposure. Am J Public Health 1998;88:1834–6
    1. Jiang RO, Cheng KI, Acevedo-Bolton V, et al. Measurement of fine particles and smoking activity in a statewide survey of 36 California Indian Casinos. J Expo Sci Environ Epidemiol 2011;21:31–41
    1. Liu R, Yang Y, Travers MJ, et al. A cross sectional study on levels of secondhand smoke in restaurants and bars in five cities in China. Tob Control 2011;20:397–402
    1. Saade G, Seidenberg AB, Rees VW, et al. Indoor secondhand tobacco smoke emission levels in six Lebanese Cities. Tob Control 2010;19:138–42

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