New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial

Rishi Gupta, Jeffrey L Saver, Elad Levy, Osama O Zaidat, Dileep Yavagal, David S Liebeskind, Ahmad Khaldi, Bradley Gross, Michael Lang, Sandra Narayanan, Brian Jankowitz, Kenneth Snyder, Adnan Siddiqui, Jason Davies, Eugene Lin, Ameer Hassan, Ricardo Hanel, Amin Aghaebrahim, Ritesh Kaushal, Ali Malek, Nils Mueller-Kronast, Robert Starke, Hormozd Bozorgchami, Gary Nesbit, Masahiro Horikawa, Ryan Priest, Jesse Liu, Ronald F Budzik, Peter Pema, Nirav Vora, M Asif Taqi, Edgar Samaniego, Qingliang Tony Wang, Erez Nossek, Guilherme Dabus, Italo Linfante, Ajit Puri, Eitan Abergel, Sidney Starkman, Satoshi Tateshima, Ashutosh P Jadhav, TIGER Trial Investigators, Rishi Gupta, Jeffrey L Saver, Elad Levy, Osama O Zaidat, Dileep Yavagal, David S Liebeskind, Ahmad Khaldi, Bradley Gross, Michael Lang, Sandra Narayanan, Brian Jankowitz, Kenneth Snyder, Adnan Siddiqui, Jason Davies, Eugene Lin, Ameer Hassan, Ricardo Hanel, Amin Aghaebrahim, Ritesh Kaushal, Ali Malek, Nils Mueller-Kronast, Robert Starke, Hormozd Bozorgchami, Gary Nesbit, Masahiro Horikawa, Ryan Priest, Jesse Liu, Ronald F Budzik, Peter Pema, Nirav Vora, M Asif Taqi, Edgar Samaniego, Qingliang Tony Wang, Erez Nossek, Guilherme Dabus, Italo Linfante, Ajit Puri, Eitan Abergel, Sidney Starkman, Satoshi Tateshima, Ashutosh P Jadhav, TIGER Trial Investigators

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT03474549.

Keywords: goal; intracranial hemorrhage; laboratories; reperfusion; stent.

Figures

Figure 1.
Figure 1.
Tigertriever device and chart of patient flow through study.A, Tigertriever device including external handle for the operator to control the degree of expansion of the stent retriever. Fine wire mesh mounted on a flexible shaft. The design of the wire mesh (magnified view) is optimized to penetrate the clot and encapsulate it during retrieval. B, Patient screening, enrollment, treatment, and follow-up. ICH indicates intracranial hemorrhage; LVO, large vessel occlusion; mRS, modified Rankin Scale; and NIHSS, National Institutes of Health Stroke Scale.
Figure 2.
Figure 2.
Reperfusion and functional outcomes in main-study phase of TIGER trial (Treatment With Intent to Generate Endovascular Reperfusion).A, Reperfusion degree after first pass, after up to 3 Tigertriever passes, and after rescue therapy. B, Distribution of 90-d global disability outcomes on the modified Rankin Scale (mRS). mRS was available from 114 patients out of the 117 of the main-study group. mTICI indicates modified Thrombolysis in Cerebral Ischemia.

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