Predisposition for delirium and EEG characteristics
S J T van Montfort, E van Dellen, L L Wattel, I M J Kant, T Numan, C J Stam, A J C Slooter, S J T van Montfort, E van Dellen, L L Wattel, I M J Kant, T Numan, C J Stam, A J C Slooter
Abstract
Objective: Delirium is associated with increased electroencephalography (EEG) delta activity, decreased connectivity strength and decreased network integration. To improve our understanding of development of delirium, we studied whether non-delirious individuals with a predisposition for delirium also show these EEG abnormalities.
Methods: Elderly subjects (N = 206) underwent resting-state EEG measurements and were assessed on predisposing delirium risk factors, i.e. older age, alcohol misuse, cognitive impairment, depression, functional impairment, history of stroke and physical status. Delirium-related EEG characteristics of interest were relative delta power, alpha connectivity strength (phase lag index) and network integration (minimum spanning tree leaf fraction). Linear regression analyses were used to investigate the relation between predisposing delirium risk factors and EEG characteristics that are associated with delirium, adjusting for confounding and multiple testing.
Results: Functional impairment was related to a decrease in connectivity strength (adjusted R2 = 0.071, β = 0.201, p < 0.05). None of the other risk factors had significant influence on EEG delta power, connectivity strength or network integration.
Conclusions: Functional impairment seems to be associated with decreased alpha connectivity strength. Other predisposing risk factors for delirium had no effect on the studied EEG characteristics.
Significance: Predisposition for delirium is not consistently related to EEG characteristics that can be found during delirium.
Trial registration: ClinicalTrials.gov NCT02265263.
Keywords: Delirium; EEG; Functional connectivity; Functional impairment; Graph analysis; Risk factors.
Conflict of interest statement
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
Source: PubMed