Protocol for a multicenter prospective cohort study evaluating sport activity and development of femoroacetabular impingement in the adolescent hip

Axel Öhlin, Nicole Simunovic, Andrew Duong, Olufemi R Ayeni, PREVIEW investigators, Olufemi R Ayeni, Nicole Simunovic, Andrew Duong, Yan Sim, Lehana Thabane, Matthew Skelly, Ajay Shanmugaraj, Diane Heels-Ansdell, Lisa Buckingham, Volker Musahl, Vasco V Mascarenhas, Etienne L Belzile, Sylvie Turmel, Rintje Agricola, Seung-Hoon Baek, Ae-Sun Chang, Axel Öhlin, Axel Öhlin, Nicole Simunovic, Andrew Duong, Olufemi R Ayeni, PREVIEW investigators, Olufemi R Ayeni, Nicole Simunovic, Andrew Duong, Yan Sim, Lehana Thabane, Matthew Skelly, Ajay Shanmugaraj, Diane Heels-Ansdell, Lisa Buckingham, Volker Musahl, Vasco V Mascarenhas, Etienne L Belzile, Sylvie Turmel, Rintje Agricola, Seung-Hoon Baek, Ae-Sun Chang, Axel Öhlin

Abstract

Background: Femoroacetabular impingement (FAI) is an important cause of hip pain in young and active individuals and occurs as a result of size and shape mismatch between the femoral head and acetabulum. Open physes in children can make hips more susceptible to injury, and high impact forces have been suggested to affect the developing femur. The diagnosis of FAI has recently risen, especially within adolescent populations, and there is an increasing trend towards year-round participation in sports with early specialization. The PREVIEW study is an international longitudinal study designed to determine the association between sport specialization in adolescence and the development of hip impingement.

Methods: This is a multicentre prospective cohort study evaluating 200 participants between the ages of 12-14 that include sport specialists at the moderate to vigorous physical activity (MVPA) level and non-sport specialists at any activity level. We will monitor physical activity levels of all participants using an activity log and a wrist-mounted activity tracker, with synced data collected every 3 months during the study period. In addition, participants will be evaluated clinically at 6, 12, and 18 months and radiographically at the time of enrolment and 24 months. The primary outcome is the incidence of FAI between groups at 2 years, determined via MRI. Secondary outcomes include hip function and health-related quality of life between subjects diagnosed with FAI versus no FAI at 2 years, as determined by the Hip Outcome Score (HOS) and Pediatric Quality of Life (PedsQL) questionnaires.

Discussion: It is important to mitigate the risk of developing hip deformities at a young age. Our proposed prospective evaluation of the impact of sport activity and hip development is relevant in this era of early sport specialization in youth. Improving the understanding between sport specialization and the development of pre-arthritic hip disease such as FAI can lead to the development of training protocols that protect the millions of adolescents involved in sports annually.

Trial registration: PREVIEW is registered with clinicaltrials.gov (NCT03891563).

Keywords: Adolescents; Femoroacetabular impingement; Magnetic resonance imaging; Sport specialization.

Conflict of interest statement

Dr. Olufemi Ayeni is an Associate Editor of the BMC Musculoskeletal Disorders Journal.

Figures

Fig. 1
Fig. 1
PREVIEW Study Organization

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