EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot)
Aldo P Maggioni, Ulf Dahlström, Gerasimos Filippatos, Ovidiu Chioncel, Marisa Crespo Leiro, Jaroslaw Drozdz, Friedrich Fruhwald, Lars Gullestad, Damien Logeart, Gianna Fabbri, Renato Urso, Marco Metra, John Parissis, Hans Persson, Piotr Ponikowski, Mathias Rauchhaus, Adriaan A Voors, Olav Wendelboe Nielsen, Faiez Zannad, Luigi Tavazzi, Heart Failure Association of the European Society of Cardiology (HFA), Aldo Maggioni, Ulf Dahlström, Gerasimos Filippatos, Luigi Tavazzi, Faiez Zannad, Friedrich Fruhwald, Olav Wendelboe Nielsen, Damien Logeart, Mathias Rauchhaus, John Parissis, Marco Metra, Adriaan Voors, Lars Gullestad, Jaroslaw Drozdz, Ovidiu Chioncel, Marisa Crespo Leiro, Ulf Dahlström, Hans Persson, Angeles Alonso, Roberto Ferrari, Michel Komajda, Luigi Tavazzi, David Wood, Malika Manini, Charles Taylor, Cécile Laroche, Emanuela Fiorucci, Donata Lucci, Lucio Gonzini, J Auer, A Oberrauner, F Fruhwald, M Schumacher, C Ebner, A Hallas, G Espersen, F Gustafsson, N Mattsson, O Wendelboe Nielsen, K Egstrup, S Aagaard, T Gohr, K Huld, A Sejr Knudsen, J Refsgaard, J Charniot, A Juillard, P Pon-Gabrielsen, F Douna, G Jondeau, D Logeart, P Jourdain, L Michel, C Hamm, S Lehinant, A Rieth, O Goeing, H-P Schultheiss, J Von-Schlippenbach, R Knollmann, C Neubüser, H A Katus, T Taeger, C Zugck, H Fink, J Schulz, S Held, W Karmann, J Kreuzer, K Nitsche, K Winter, A Fahnrich, K Bruederlein, M Rauchhaus, C H Turan, J Berentelg, T Ittel, C Rubens, M Hanke, S Stoerk, C Chrysohoou, E Kaldara, A Karavidas, R Margari, V Matzaraki, J Nanas, J T Parissis, I Pozios, P Psarogiannakopoulos, V Pyrgakis, C Stefanadis, J Terrovitis, A Trikas, S Xydonas, A Patrianakos, P Vardas, A Douras, J Nastas, K Ntertsas, T Tsaknakis, P Midi, G Pajes, L Moretti, M Partemi, F Barberini, A Branzi, I Gallelli, F Grigioni, T Ionico, F Pasquale, L Dei Cas, F Delmagro, M Metra, E Tanghetti, A Vaccari, G Mercuro, G M Arcuri, L Marinacci, D Severini, F Cosmi, S Bosi, L Tavazzi, G Di Tano, S Pirelli, R Ferrari, A Fucili, C Minneci, G M Santoro, M Correale, M Di Biase, M Buccolieri, S Mandorla, S Martinelli, M Barbiero, A Giordano, E Zanelli, P Agostoni, C Fiorentini, E Salvioni, C Leuzzi, M G Modena, L Reggianini, F Cobelli, C Opasich, P Baldini, M Romei, G Pulitano, A Ruggeri, F Bologna, G Piovaccari, B Brasolin, F Fedele, M Merlo, G Sinagra, M C Albanese, D Miani, G Linssen, E Rodijk, Y Pinto, P Van Donk, P Dunselman, D Lok, F Brouwers, R M De Jong, R Boen, T Hole, L Rasmussen, E M Christiansen, E Gjertsen, J Lyng, M German, G Hogalmen, L Gullestad, R Skardal, T Apelland, M Figenboum Borgen, E Forfang, T Baak, K Dickstein, I Eide Olsen, D Stachurski, Z Juszczyk, S Stankala, W Gilewski, W Sinkiewicz, P Kasztelowicz, J Gabryel, P Kardaszewicz, M Lazorko-Piega, J Bellwon, K Mosakowska, A Rynkiewicz, S Olczyk, M Pagorek, R Bartlinski, G Borej, J Tarchalski, R Bartkowiak, B Sosnowska-Pasiarska, B Wozakowska-Kaplon, A Krzeminski, K Bury, A Grzegorzko, E Mirek-Bryniarska, J Nessler, M Zabojszcz, M Broncel, J Drozdz, A Poliwczak, A Retwinski, K Wojtczak Soska, S Grajek, E Straburzynska-Migaj, J Kuzniar, T Rzeszuto, G Bednarczyk, P Ruszkowski, E Piasecka-Krysiak, J Zambrzycki, T Nowak, R Szelemej, P Balsam, A Folga, A Kaplon-Cieslicka, S Kowalewski, A Mamcarz, M Marchel, G Opolski, M Welnicki, E Jankowska, P Ponikowski, J Nowak, E Nowalany-Kozielska, P Rozentryt, M Zembala, A Kleinrok, G Prokop-Lewicka, B Kudlinska, M Radoi, C Macarie, D Vinereanu, R Capalneanu, A Giuca, D D Ionescu, E Nechita, M Datcu, C Istrate, M Vladoianu, R Christodorescu, R Lopez Salguero, V M Rodriguez Blanco, M A Castel Lavilla, J Comin-Colet, D Silva Cantillo, J Ortega Bernal, J M Arizon del Prado, A Melero Pita, J Aguero, M Crespo-Leiro, J F Delgado Jimenez, F Torres Calvo, R Izquierdo Gonzalez, B Díaz Molina, D Cremer Luengos, C Navarro Lostal, L Almenar Bonet, P Garcia Gonzalez, F Ridocci Soriano, M J Bosch Campos, P Karlstrom, I Nyrinder, B Olsson, T Pettersson, A Stenberg, U Dahlström, K Lindmark, B Asserlund, Aldo P Maggioni, Ulf Dahlström, Gerasimos Filippatos, Ovidiu Chioncel, Marisa Crespo Leiro, Jaroslaw Drozdz, Friedrich Fruhwald, Lars Gullestad, Damien Logeart, Gianna Fabbri, Renato Urso, Marco Metra, John Parissis, Hans Persson, Piotr Ponikowski, Mathias Rauchhaus, Adriaan A Voors, Olav Wendelboe Nielsen, Faiez Zannad, Luigi Tavazzi, Heart Failure Association of the European Society of Cardiology (HFA), Aldo Maggioni, Ulf Dahlström, Gerasimos Filippatos, Luigi Tavazzi, Faiez Zannad, Friedrich Fruhwald, Olav Wendelboe Nielsen, Damien Logeart, Mathias Rauchhaus, John Parissis, Marco Metra, Adriaan Voors, Lars Gullestad, Jaroslaw Drozdz, Ovidiu Chioncel, Marisa Crespo Leiro, Ulf Dahlström, Hans Persson, Angeles Alonso, Roberto Ferrari, Michel Komajda, Luigi Tavazzi, David Wood, Malika Manini, Charles Taylor, Cécile Laroche, Emanuela Fiorucci, Donata Lucci, Lucio Gonzini, J Auer, A Oberrauner, F Fruhwald, M Schumacher, C Ebner, A Hallas, G Espersen, F Gustafsson, N Mattsson, O Wendelboe Nielsen, K Egstrup, S Aagaard, T Gohr, K Huld, A Sejr Knudsen, J Refsgaard, J Charniot, A Juillard, P Pon-Gabrielsen, F Douna, G Jondeau, D Logeart, P Jourdain, L Michel, C Hamm, S Lehinant, A Rieth, O Goeing, H-P Schultheiss, J Von-Schlippenbach, R Knollmann, C Neubüser, H A Katus, T Taeger, C Zugck, H Fink, J Schulz, S Held, W Karmann, J Kreuzer, K Nitsche, K Winter, A Fahnrich, K Bruederlein, M Rauchhaus, C H Turan, J Berentelg, T Ittel, C Rubens, M Hanke, S Stoerk, C Chrysohoou, E Kaldara, A Karavidas, R Margari, V Matzaraki, J Nanas, J T Parissis, I Pozios, P Psarogiannakopoulos, V Pyrgakis, C Stefanadis, J Terrovitis, A Trikas, S Xydonas, A Patrianakos, P Vardas, A Douras, J Nastas, K Ntertsas, T Tsaknakis, P Midi, G Pajes, L Moretti, M Partemi, F Barberini, A Branzi, I Gallelli, F Grigioni, T Ionico, F Pasquale, L Dei Cas, F Delmagro, M Metra, E Tanghetti, A Vaccari, G Mercuro, G M Arcuri, L Marinacci, D Severini, F Cosmi, S Bosi, L Tavazzi, G Di Tano, S Pirelli, R Ferrari, A Fucili, C Minneci, G M Santoro, M Correale, M Di Biase, M Buccolieri, S Mandorla, S Martinelli, M Barbiero, A Giordano, E Zanelli, P Agostoni, C Fiorentini, E Salvioni, C Leuzzi, M G Modena, L Reggianini, F Cobelli, C Opasich, P Baldini, M Romei, G Pulitano, A Ruggeri, F Bologna, G Piovaccari, B Brasolin, F Fedele, M Merlo, G Sinagra, M C Albanese, D Miani, G Linssen, E Rodijk, Y Pinto, P Van Donk, P Dunselman, D Lok, F Brouwers, R M De Jong, R Boen, T Hole, L Rasmussen, E M Christiansen, E Gjertsen, J Lyng, M German, G Hogalmen, L Gullestad, R Skardal, T Apelland, M Figenboum Borgen, E Forfang, T Baak, K Dickstein, I Eide Olsen, D Stachurski, Z Juszczyk, S Stankala, W Gilewski, W Sinkiewicz, P Kasztelowicz, J Gabryel, P Kardaszewicz, M Lazorko-Piega, J Bellwon, K Mosakowska, A Rynkiewicz, S Olczyk, M Pagorek, R Bartlinski, G Borej, J Tarchalski, R Bartkowiak, B Sosnowska-Pasiarska, B Wozakowska-Kaplon, A Krzeminski, K Bury, A Grzegorzko, E Mirek-Bryniarska, J Nessler, M Zabojszcz, M Broncel, J Drozdz, A Poliwczak, A Retwinski, K Wojtczak Soska, S Grajek, E Straburzynska-Migaj, J Kuzniar, T Rzeszuto, G Bednarczyk, P Ruszkowski, E Piasecka-Krysiak, J Zambrzycki, T Nowak, R Szelemej, P Balsam, A Folga, A Kaplon-Cieslicka, S Kowalewski, A Mamcarz, M Marchel, G Opolski, M Welnicki, E Jankowska, P Ponikowski, J Nowak, E Nowalany-Kozielska, P Rozentryt, M Zembala, A Kleinrok, G Prokop-Lewicka, B Kudlinska, M Radoi, C Macarie, D Vinereanu, R Capalneanu, A Giuca, D D Ionescu, E Nechita, M Datcu, C Istrate, M Vladoianu, R Christodorescu, R Lopez Salguero, V M Rodriguez Blanco, M A Castel Lavilla, J Comin-Colet, D Silva Cantillo, J Ortega Bernal, J M Arizon del Prado, A Melero Pita, J Aguero, M Crespo-Leiro, J F Delgado Jimenez, F Torres Calvo, R Izquierdo Gonzalez, B Díaz Molina, D Cremer Luengos, C Navarro Lostal, L Almenar Bonet, P Garcia Gonzalez, F Ridocci Soriano, M J Bosch Campos, P Karlstrom, I Nyrinder, B Olsson, T Pettersson, A Stenberg, U Dahlström, K Lindmark, B Asserlund
Abstract
Aims: The ESC-HF Pilot survey was aimed to describe clinical epidemiology and 1-year outcomes of outpatients and inpatients with heart failure (HF). The pilot phase was also specifically aimed at validating structure, performance, and quality of the data set for continuing the survey into a permanent Registry.
Methods: The ESC-HF Pilot study is a prospective, multicentre, observational survey conducted in 136 Cardiology Centres in 12 European countries selected to represent the different health systems across Europe. All outpatients with HF and patients admitted for acute HF on 1 day per week for eight consecutive months were included. From October 2009 to May 2010, 5118 patients were included: 1892 (37%) admitted for acute HF and 3226 (63%) patients with chronic HF. The all-cause mortality rate at 1 year was 17.4% in acute HF and 7.2% in chronic stable HF. One-year hospitalization rates were 43.9% and 31.9%, respectively, in hospitalized acute and chronic HF patients. Major regional differences in 1-year mortality were observed that could be explained by differences in characteristics and treatment of the patients.
Conclusion: The ESC-HF Pilot survey confirmed that acute HF is still associated with a very poor medium-term prognosis, while the widespread adoption of evidence-based treatments in patients with chronic HF seems to have improved their outcome profile. Differences across countries may be due to different local medical practice as well to differences in healthcare systems. This pilot study also offered the opportunity to refine the organizational structure for a long-term extended European network.
Keywords: Acute heart failure; Chronic heart failure; Observational studies; Pharmacological treatments; Prognosis.
Source: PubMed