Endovascular aortic repair increases vascular stiffness and alters cardiac structure and function
Yasuharu Takeda, Yasushi Sakata, Tomohito Ohtani, Shunsuke Tamaki, Yosuke Omori, Yasumasa Tsukamoto, Yoshihiro Aizawa, Kazuo Shimamura, Yukitoshi Shirakawa, Toru Kuratani, Yoshiki Sawa, Kazuhiro Yamamoto, Toshiaki Mano, Issei Komuro, Yasuharu Takeda, Yasushi Sakata, Tomohito Ohtani, Shunsuke Tamaki, Yosuke Omori, Yasumasa Tsukamoto, Yoshihiro Aizawa, Kazuo Shimamura, Yukitoshi Shirakawa, Toru Kuratani, Yoshiki Sawa, Kazuhiro Yamamoto, Toshiaki Mano, Issei Komuro
Abstract
Background: Endovascular aortic repair (EVAR) is performed in patients with thoracic or abdominal aortic aneurysm because it is less invasive than conventional open repair. However, the effects of EVAR on vascular and cardiac function remain to be clarified.
Methods and results: We studied the effects of EVAR on several outcome variables in 40 consecutive patients undergoing EVAR for abdominal and/or thoracic aneurysm with preserved ejection fraction. Echocardiography and brachial-ankle pulse wave velocity (baPWV) data were collected before, 1 week, and 1 year after EVAR. Although no changes in blood pressure were found, baPWV, left ventricular mass index (LVMI), and left atrial volume index were significantly elevated at both post-op time periods after EVAR compared with baseline data. The changes in LVMI correlated with those in baPWV (R=0.32, P<0.05). Among the 22 patients who were successfully followed up, 13 showed deterioration in exercise tolerance 1 year after EVAR. Diastolic wall strain, an index for LV distensibility, was lower at baseline in patients with worsening exercise tolerance than in those with unchanged tolerance.
Conclusions: EVAR increased vascular stiffness and induced LV hypertrophy and diastolic dysfunction without a corresponding elevation of blood pressure in the acute and chronic phases. In addition, low LV distensibility at baseline was associated with the impairment of exercise tolerance. EVAR-induced stiffness of arteries leads to limited clinical symptoms.
Source: PubMed