Simons Variation in Individuals Project (Simons VIP): a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders
Simons Vip Consortium, John E Spiro, Arthur L Beaudet, Christie M Brewton, Zili Chu, Allison G Dempsey, Yolanda L Evans, Silvia Garza, Jill V Hunter, Stephen M Kanne, Anna L Laakman, Morgan W Lasala, Ashlie V Llorens, Gabriela Marzano, Timothy J Moss, Kerri P Nowell, Monica B Proud, Melissa B Ramocki, Qixuan Chen, Roger Vaughan, Jeffrey Berman, Lisa Blaskey, Katherine Hines, Sudha Kessler, Sarah Y Khan, Saba Qasmieh, Audrey Lynn Bibb, Andrea M Paal, Patricia Z Page, Bethanny Smith-Packard, Randy Buckner, Jordan Burko, Alyss Lian Cavanagh, Bettina Cerban, Anne V Snow, P Ellen Grant, LeeAnne Green Snyder, Rebecca McNally Keehn, David T Miller, Fiona K Miller, Jennifer Endre Olson, Sarah J Spence, Christina Triantafallou, Nicole Visyak, Constance Atwell, Marta Benedetti, Gerald D Fischbach, Marion Greenup, Alan Packer, Jennifer Tjernagel, Polina Bukshpun, Maxwell Cheong, Corby Dale, Sarah E Gobuty, Leighton Hinkley, Rita J Jeremy, Hana Lee, Tracy L Luks, Elysa J Marco, Alastair J Martin, Kathleen E McGovern, Pratik Mukherjee, Srikantan S Nagarajan, Julia Owen, Brianna M Paul, Nicholas J Pojman, Tuhin Sinha, Vivek Swarnakar, Mari Wakahiro, Hanalore Alupay, Benjamin Aaronson, Sean Ackerman, Katy Ankenmann, Elizabeth Aylward, Jenna Elgin, Jennifer Gerdts, Kelly Johnson, Beau Reilly, Dennis Shaw, Kyle Steinman, Arianne Stevens, Tracey Ward, Julia Wenegrat, Timothy P L Roberts, David H Ledbetter, Christa Lese Martin, Robin P Goin-Kochel, Raphael Bernier, W Andrew Faucett, Elliott H Sherr, Ellen Hanson, Wendy K Chung, Simons Vip Consortium, John E Spiro, Arthur L Beaudet, Christie M Brewton, Zili Chu, Allison G Dempsey, Yolanda L Evans, Silvia Garza, Jill V Hunter, Stephen M Kanne, Anna L Laakman, Morgan W Lasala, Ashlie V Llorens, Gabriela Marzano, Timothy J Moss, Kerri P Nowell, Monica B Proud, Melissa B Ramocki, Qixuan Chen, Roger Vaughan, Jeffrey Berman, Lisa Blaskey, Katherine Hines, Sudha Kessler, Sarah Y Khan, Saba Qasmieh, Audrey Lynn Bibb, Andrea M Paal, Patricia Z Page, Bethanny Smith-Packard, Randy Buckner, Jordan Burko, Alyss Lian Cavanagh, Bettina Cerban, Anne V Snow, P Ellen Grant, LeeAnne Green Snyder, Rebecca McNally Keehn, David T Miller, Fiona K Miller, Jennifer Endre Olson, Sarah J Spence, Christina Triantafallou, Nicole Visyak, Constance Atwell, Marta Benedetti, Gerald D Fischbach, Marion Greenup, Alan Packer, Jennifer Tjernagel, Polina Bukshpun, Maxwell Cheong, Corby Dale, Sarah E Gobuty, Leighton Hinkley, Rita J Jeremy, Hana Lee, Tracy L Luks, Elysa J Marco, Alastair J Martin, Kathleen E McGovern, Pratik Mukherjee, Srikantan S Nagarajan, Julia Owen, Brianna M Paul, Nicholas J Pojman, Tuhin Sinha, Vivek Swarnakar, Mari Wakahiro, Hanalore Alupay, Benjamin Aaronson, Sean Ackerman, Katy Ankenmann, Elizabeth Aylward, Jenna Elgin, Jennifer Gerdts, Kelly Johnson, Beau Reilly, Dennis Shaw, Kyle Steinman, Arianne Stevens, Tracey Ward, Julia Wenegrat, Timothy P L Roberts, David H Ledbetter, Christa Lese Martin, Robin P Goin-Kochel, Raphael Bernier, W Andrew Faucett, Elliott H Sherr, Ellen Hanson, Wendy K Chung
Abstract
We describe a project aimed at studying a large number of individuals (>200) with specific recurrent genetic variations (deletion or duplication of segment 16p11.2) that increase the risk of developing autism spectrum (ASD) and other developmental disorders. The genetics-first approach augmented by web-based recruitment, multisite collaboration and calibration, and robust data-sharing policies could be adopted by other groups studying neuropsychiatric disorders to accelerate the pace of research.
Copyright © 2012 Elsevier Inc. All rights reserved.
Source: PubMed