The Management and Outcomes of Pharmacological Treatments for Tinnitus

Devon Beebe Palumbo, Kathleen Joos, Dirk De Ridder, Sven Vanneste, Devon Beebe Palumbo, Kathleen Joos, Dirk De Ridder, Sven Vanneste

Abstract

Tinnitus, a phantom sensation experienced by people around the world, currently is endured without a known cure. Some find the condition tolerable, while others are tortured on a daily basis from the incessant phantom noises. For those who seek treatment, oftentimes, they have a comorbid condition (e.g., depression, anxiety, insomnia), which is treated pharmaceutically. These products aim to reduce the comorbities associated with tinnitus thereby minimizing the overall burden present. Because of the phantom nature of tinnitus, it is often compared to neurologic pain. Since pain can be managed with pharmaceutical options, it is reasonable to assume that similar agents might work to alleviate tinnitus. The effects of antidepressants, benzodiazepines, anticonvulsants, and glutamate antagonists are reviewed in this paper. Table 1 summarizes the pharmaceutical products discussed. Due to the variety of comorbid factors and potential causes of tinnitus, there may not be one pharmaceutical treatment that will combat every type of tinnitus. Nevertheless, a product that finally addresses the true cause of tinnitus, and not just its comorbidities, will benefit millions of people worldwide.

References

    1. Shargorodsky J., Curhan G.C., Farwell W.R. Prevalence and characteristics of tinnitus among US adults. Am. J. Med. 2010;123(8):711–718. doi: 10.1016/j.amjmed.2010.02.015.
    1. Krog N.H., Engdahl B., Tambs K. The association between tinnitus and mental health in a general population sample: results from the HUNT Study. J. Psychosom. Res. 2010;69(3):289–298. doi: 10.1016/j.jpsychores.2010.03.008.
    1. Davis A., El Rafaie A. In: Epidemiology of Tinnitus; Tyler, R. S. Handbook T., Singular T.L., editors. San Diego, CA: 2000. pp. 1–23.
    1. Joos K., Vanneste S., De Ridder D. Disentangling depression and distress networks in the tinnitus brain. PLoS One. 2012;7(7):e40544. doi: 10.1371/journal.pone.0040544.
    1. Schecklmann M., Landgrebe M., Poeppl T.B., Kreuzer P., Männer P., Marienhagen J., Wack D.S., Kleinjung T., Hajak G., Langguth B. Neural correlates of tinnitus duration and distress: a positron emission tomography study. Hum. Brain Mapp. 2013;34(1):233–240. doi: 10.1002/hbm.21426.
    1. Vanneste S., Joos K., De Ridder D. Prefrontal cortex based sex differences in tinnitus perception: same tinnitus intensity, same tinnitus distress, different mood. PLoS One. 2012;7(2):e31182. doi: 10.1371/journal.pone.0031182.
    1. Golm D., Schmidt-Samoa C., Dechent P., Kroner-Herwig B. Neural correlates of tinnitus related distress: an fMRI-study. 2013.
    1. Langguth B., Kreuzer P.M., Kleinjung T., De Ridder D. Tinnitus: causes and clinical management. Lancet Neurol. 2013;12(9):920–930. doi: 10.1016/S1474-4422(13)70160-1.
    1. House J.W., Brackmann D.E. Tinnitus: Surgical Treatment. Ciba Foundation Symposium. . 1981;85:204–216. doi: 10.1002/9780470720677.ch12.
    1. Kreuzer P.M., Landgrebe M., Vielsmeier V., Kleinjung T., De Ridder D., Langguth B. Trauma-associated tinnitus. J. Head Trauma Rehabil. 2014;29(5):432–442. doi: 10.1097/HTR.0b013e31829d3129.
    1. Moller A.R. Pathophysiology of tinnitus. 2003.
    1. Møller A.R. Similarities between chronic pain and tinnitus. Am. J. Otol. 1997;18(5):577–585.
    1. Moller A.R. Similarities between severe tinnitus and chronic pain. J. Am. Acad. Audiol. 2000;11(3):115–124.
    1. Tonndorf J. The analogy between tinnitus and pain: a suggestion for a physiological basis of chronic tinnitus. Hear. Res. 1987;28(2-3):271–275. doi: 10.1016/0378-5955(87)90054-2.
    1. De Ridder D., Elgoyhen A.B., Romo R., Langguth B. Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc. Natl. Acad. Sci. USA. 2011;108(20):8075–8080. doi: 10.1073/pnas.1018466108.
    1. Cacace A.T., Cousins J.P., Parnes S.M., Semenoff D., Holmes T., McFarland D.J., Davenport C., Stegbauer K., Lovely T.J. Cutaneous-evoked tinnitus. I. Phenomenology, psychophysics and functional imaging. Audiol. Neurootol. 1999;4(5):247–257. doi: 10.1159/000013848.
    1. Cacace A.T., Cousins J.P., Parnes S.M., McFarland D.J., Semenoff D., Holmes T., Davenport C., Stegbauer K., Lovely T.J. Cutaneous-evoked tinnitus. II. Review Of neuroanatomical, physiological and functional imaging studies. Audiol. Neurootol. 1999;4(5):258–268. doi: 10.1159/000013849.
    1. LeDoux J.E. Brain mechanisms of emotion and emotional learning. Curr. Opin. Neurobiol. 1992;2(2):191–197. doi: 10.1016/0959-4388(92)90011-9.
    1. Melding P.S., Goodey R.J., Thorne P.R. The use of intravenous lignocaine in the diagnosis and treatment of tinnitus. J. Laryngol. Otol. 1978;92(2):115–121. doi: 10.1017/S002221510008511X.
    1. De Ridder D., Vanneste S., Engineer N.D., Kilgard M.P. Safety and efficacy of vagus nerve stimulation paired with tones for the treatment of tinnitus: a case series. Neuromodulation. 2014;17(2):170–179. doi: 10.1111/ner.12127.
    1. Engineer N.D., Riley J.R., Seale J.D., Vrana W.A., Shetake J.A., Sudanagunta S.P., Borland M.S., Kilgard M.P. Reversing pathological neural activity using targeted plasticity. Nature. 2011;470(7332):101–104. doi: 10.1038/nature09656.
    1. Zheng Y., McNamara E., Stiles L., Darlington C.L., Smith P.F. Evidence that Memantine Reduces Chronic Tinnitus Caused by Acoustic Trauma in Rats. Front. Neurol. 2012;3:127. doi: 10.3389/fneur.2012.00127.
    1. Figueiredo R.R., Langguth B., Mello de Oliveira P., Aparecida de Azevedo A. Tinnitus treatment with memantine. Otolaryngol. Head Neck Surg. 2008;138(4):492–496. doi: 10.1016/j.otohns.2007.11.027.
    1. Zheng Y., Hooton K., Smith P.F., Darlington C.L. Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatment in rats. Acta Otolaryngol. 2008;128(1):48–52. doi: 10.1080/00016480701361939.
    1. Hoekstra C.E., Rynja S.P., van Zanten G.A., Rovers M.M. Anticonvulsants for tinnitus. 2011.
    1. Moller A.R. A double-blind placebo-controlled trial of baclofen in the treatment of tinnitus. Am. J. Otol. 1997;18(2):268–269. doi: 10.1016/S0079-6123(07)66036-1.
    1. De Ridder D., De Mulder G., Menovsky T., Sunaert S., Kovacs S. Electrical stimulation of auditory and somatosensory cortices for treatment of tinnitus and pain. Prog. Brain Res. 2007;166:377–388. doi: 10.1016/S0079-6123(07)66036-1.
    1. De Ridder D., Moller A., Langguth B., De Ridder D., Kleinjung T. Textbook of Tinnitus. New York: Springer:; 2011. In Similarities between treatments of tinnitus and central pain; pp. 753–762.
    1. De Ridder D., Vanneste S., Menovsky T., Langguth B. Surgical brain modulation for tinnitus: the past, present and future. J. Neurosurg. Sci. 2012;56(4):323–340.
    1. De Ridder D., Ryu H., Møller A.R., Nowé V., Van de Heyning P., Verlooy J. Functional anatomy of the human cochlear nerve and its role in microvascular decompressions for tinnitus. Neurosurgery. 2004;54(2):381–388. doi: 10.1227/01.NEU.0000103420.53487.79.
    1. Levine R.A. Somatic (craniocervical) tinnitus and the dorsal cochlear nucleus hypothesis. Am. J. Otolaryngol. 1999;20(6):351–362. doi: 10.1016/S0196-0709(99)90074-1.
    1. Puel J.L. Chemical synaptic transmission in the cochlea. Prog. Neurobiol. 1995;47(6):449–476. doi: 10.1016/0301-0082(95)00028-3.
    1. Puel J.L., Ruel J., Guitton M., Pujol R. The inner hair cell afferent/efferent synapses revisited: a basis for new therapeutic strategies. Adv. Otorhinolaryngol. 2002;59:124–130. doi: 10.1159/000059250.
    1. Szczepaniak W.S., Moller A.R. Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis. Hear Res. . 1996; 97 : 46 –53. doi: 10.1016/0378-5955(96)00052-4.
    1. Baldo P., Doree C., Lazzarini R., Molin P., McFerran D.J. Antidepressants for patients with tinnitus. 2006.
    1. Sullivan M.D., Dobie R.A., Sakai C.S., Katon W.J. Treatment of depressed tinnitus patients with nortriptyline. Ann. Otol. Rhinol. Laryngol. 1989;98(11):867–872. doi: 10.1177/000348948909801107.
    1. Sullivan M., Katon W., Russo J., Dobie R., Sakai C. A randomized trial of nortriptyline for severe chronic tinnitus. 1993.
    1. Podoshin L., Ben-David Y., Fradis M., Malatskey S., Hafner H. Idiopathic Subjective Tinnitus Treated by Amitriptyline Hydrochloride/Biofeedback. Int. Tinnitus J. 1995;1(1):54–60.
    1. Bayar N., Böke B., Turan E., Belgin E. Efficacy of amitriptyline in the treatment of subjective tinnitus. J. Otolaryngol. 2001;30(5):300–303. doi: 10.2310/7070.2001.19597.
    1. Mendis D., Johnston M. An unusual case of prolonged tinnitus following low-dose amitriptyline. J. Psychopharmacol. (Oxford) 2008;22(5):574–575. doi: 10.1177/0269881107082126.
    1. Tandon R., Grunhaus L., Greden J.F. Imipramine and tinnitus. J. Clin. Psychiatry. 1987;48(3):109–111.
    1. Evans D.L., Golden R.N. Protriptyline and tinnitus. J. Clin. Psychopharmacol. 1981;1(6):404–406. doi: 10.1097/00004714-198111000-00013.
    1. Zöger S., Svedlund J., Holgers K.M. The effects of sertraline on severe tinnitus suffering--a randomized, double-blind, placebo-controlled study. J. Clin. Psychopharmacol. 2006;26(1):32–39. doi: 10.1097/01.jcp.0000195111.86650.19.
    1. Robinson S.K., Viirre E.S., Bailey K.A., Gerke M.A., Harris J.P., Stein M.B. Randomized placebo-controlled trial of a selective serotonin reuptake inhibitor in the treatment of nondepressed tinnitus subjects. 2005.
    1. Meeus O., De Ridder D., Van de Heyning P. Administration of the combination clonazepam-Deanxit as treatment for tinnitus. Otol. Neurotol. 2011;32(4):701–709. doi: 10.1097/MAO.0b013e31820e737c.
    1. Sziklai I., Szilvássy J., Szilvássy Z. Tinnitus control by dopamine agonist pramipexole in presbycusis patients: a randomized, placebo-controlled, double-blind study. Laryngoscope. 2011;121(4):888–893. doi: 10.1002/lary.21461.
    1. de Azevedo A.A., Langguth B., de Oliveira P.M., Rodrigues Figueiredo R. Tinnitus treatment with piribedil guided by electrocochleography and acoustic otoemissions. Otol. Neurotol. 2009;30(5):676–680. doi: 10.1097/MAO.0b013e3181ab8fd5.
    1. Salvi R., Lobarinas E., Sun W. Pharmacological Treatments for Tinnitus: New and Old. Drugs Future. 2009;34(5):381–400. doi: 10.1358/dof.2009.034.05.1362442.
    1. Johnson R.M., Brummett R., Schleuning A. Use of alprazolam for relief of tinnitus. A double-blind study. Arch. Otolaryngol. Head Neck Surg. 1993;119(8):842–845. doi: 10.1001/archotol.1993.01880200042006.
    1. Jalali M.M., Kousha A., Naghavi S.E., Soleimani R., Banan R. The effects of alprazolam on tinnitus: a cross-over randomized clinical trial. Med. Sci. Monit. 2009;15(11):PI55–PI60.
    1. Han S.S., Nam E.C., Won J.Y., Lee K.U., Chun W., Choi H.K., Levine R.A. Clonazepam quiets tinnitus: a randomised crossover study with Ginkgo biloba. J. Neurol. Neurosurg. Psychiatry. 2012;83(8):821–827. doi: 10.1136/jnnp-2012-302273.
    1. Bauer C.A., Brozoski T.J. Effect of gabapentin on the sensation and impact of tinnitus. Laryngoscope. 2006;116(5):675–681. doi: 10.1097/.
    1. Witsell D.L., Hannley M.T., Stinnet S., Tucci D.L. Treatment of tinnitus with gabapentin: a pilot study. Otol. Neurotol. 2007;28(1):11–15. doi: 10.1097/01.mao.0000235967.53474.93.
    1. Reed H.T., Meltzer J., Crews P., Norris C.H., Quine D.B., Guth P.S. Amino-oxyacetic acid as a palliative in tinnitus. Arch. Otolaryngol. 1985;111(12):803–805. doi: 10.1001/archotol.1985.00800140047008.
    1. Simpson J.J., Gilbert A.M., Weiner G.M., Davies W.E. The assessment of lamotrigine, an antiepileptic drug, in the treatment of tinnitus. Am. J. Otol. 1999;20(5):627–631.
    1. Donaldson I. Tegretol: a double blind trial in tinnitus. J. Laryngol. Otol. 1981;95(9):947–951. doi: 10.1017/S0022215100091659.
    1. Salembier L., De Ridder D., Van de Heyning P.H. The use of flupirtine in treatment of tinnitus. Acta Otolaryngol. Suppl. 2006;(556):93–95. doi: 10.1080/03655230600895242.
    1. Suckfull M., Althaus M., Ellers-Lenz B., Gebauer A., Gortelmeyer R., Jastreboff P.J., Moebius H.J., Rosenberg T., Russ H., Wirth Y., Krueger H. A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus. 2011.
    1. Sönmez O., Külahlı I., Vural A., Sahin M.I., Aydın M. The evaluation of ozone and betahistine in the treatment of tinnitus. Eur. Arch. Otorhinolaryngol. 2013;270(7):1999–2006. doi: 10.1007/s00405-012-2228-8.
    1. Canis M., Olzowy B., Welz C., Suckfüll M., Stelter K. Simvastatin and Ginkgo biloba in the treatment of subacute tinnitus: a retrospective study of 94 patients. Am. J. Otolaryngol. 2011;32(1):19–23. doi: 10.1016/j.amjoto.2009.09.004.
    1. Azevedo A.A., Figueiredo R.R. Treatment of tinnitus with acamprosate. Prog. Brain Res. 2007;166:273–277. doi: 10.1016/S0079-6123(07)66025-7.
    1. Sharma D.K., Kaur S., Singh J., Kaur I. Role of acamprosate in sensorineural tinnitus. Indian J. Pharmacol. 2012;44(1):93–96. doi: 10.4103/0253-7613.91876.
    1. Vanneste S., Azevedo A., De Ridder D. The effect of naltrexone on the perception and distress in tinnitus: an open-label pilot study. 2013.
    1. Coelho C., Figueiredo R., Frank E., Burger J., Schecklmann M., Landgrebe M., Langguth B., Elgoyhen A.B. Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study. Audiol. Neurootol. 2012;17(3):179–188. doi: 10.1159/000335657.
    1. Vanneste S., Figueiredo R., De Ridder D. Treatment of tinnitus with cyclobenzaprine: an open-label study. Int. J. Clin. Pharmacol. Ther. 2012;50(5):338–344. doi: 10.5414/CP201617.
    1. Berkiten G., Yildirim G., Topaloglu I., Ugras H. Vitamin B12 levels in patients with tinnitus and effectiveness of vitamin B12 treatment on hearing threshold and tinnitus. B-ENT. 2013;9(2):111–116.
    1. Coelho C., Witt S.A., Ji H., Hansen M.R., Gantz B., Tyler R. Zinc to treat tinnitus in the elderly: a randomized placebo controlled crossover trial. Otol. Neurotol. 2013;34(6):1146–1154. doi: 10.1097/MAO.0b013e31827e609e.
    1. Elgoyhen A.B., Langguth B., Nowak W., Schecklmann M., De Ridder D., Vanneste S. Identifying tinnitus-related genes based on a side-effect network analysis. CPT Pharmacometrics Syst. Pharmacol. 2014;3:e97. doi: 10.1038/psp.2013.75.
    1. Veterans Benefits Administration Annual Benefits Report. 2013, FY 2012. 2013.
    1. Langguth B., Elgoyhen A.B. Emerging pharmacotherapy of tinnitus. Expert Opin. Emerg. Drugs. 2011;16(4):603–606. doi: 10.1517/14728214.2011.644273.

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