A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne

A Bouloc, E Roo, B Imko-Walczuk, A Moga, B Chadoutaud, B Dréno, A Bouloc, E Roo, B Imko-Walczuk, A Moga, B Chadoutaud, B Dréno

Abstract

Introduction: Acne in adult women is an increasing reason for dermatological consultations.

Objective: The aim of this study was to assess in adult women with mild acne the efficacy and tolerance of a daily adjunctive application of a skincare (Normaderm® , Laboratoires Vichy, France) to a fixed combination of adapalene/benzoyl peroxide daily or every other evening and a standard emollient.

Methods: Subjects were randomized to receive the fixed combination applied either every evening or every other evening and a daily application of the standard emollient and the test care or a once daily application of the fixed combination and the standard emollient alone. Clinical evaluations at Day 0, Day 45 and Day 90 included the count of acne lesions, assessment of clinical improvement and local tolerance. The quantitative lipid profile of the stratum corneum of the forehead was also determined.

Results: After 90 days of application, acne had improved in all 299 subjects with a statistically significant difference in favour of the test care regimens (P < 0.05). Moreover, skin quality, subject satisfaction, skin discomfort and sebum composition were in favour of these regimens.

Conclusion: In conclusion, the tested skincare combined with a fixed adapalene and benzoyl peroxide combination provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne.

© 2017 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.

Figures

Figure 1
Figure 1
Mean acne lesion count at Day 0 and Day 90. Differences were statistically significant at Day 90 from Day 0 for all treatment groups. The difference was statistically in favour at Day 90 for Group B (1) and C (2) compared to Group A for papules and pustules (P < 0.05). Mean papules and pustules counts at D0: 11.94 for Group A, 12.04 for Group B, 12.18 for Group C. Mean papules and pustules counts at D90: 3.76 for Group A, 2.93 for Group B, 3.07 for Group C. Mean of the deltas D90 vs. D0 are −8.18 for Group A, −9.11 for Group B, −9.11 for Group C.
Figure 2
Figure 2
Skin aspect, discomfort and stinging at Day 0 and Day 90. At Day 90, all investigated items had significantly improved from Day 0 in all groups (P < 0.05). Differences between Group B and C vs. Group A at Day 90 were significant for all items.
Figure 3
Figure 3
Modifications of lipid compounds at Day 90 compared to Day 0. The differences between Group B (1) and Group C (2) were significant (P < 0.05) compared to Group A. SQOOH, oxidized squalene.

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Source: PubMed

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