Infantile Hepatic Hemangioendothelioma: An Uncommon Cause of Persistent Pulmonary Hypertension in a Newborn Infant

Trassanee Chatmethakul, Ramachandra Bhat, Maryam Alkaabi, Abdul Siddiqui, Keith Peevy, Michael Zayek, Trassanee Chatmethakul, Ramachandra Bhat, Maryam Alkaabi, Abdul Siddiqui, Keith Peevy, Michael Zayek

Abstract

Multifocal and diffuse infantile hepatic hemangioendotheliomas commonly present with signs of high-output congestive heart failure. In addition, prolonged persistent pulmonary overcirculation eventually leads to the development of pulmonary hypertension at a later age. We report a 2-day old, full-term infant with multifocal, large infantile hepatic hemangioendothelioma, who presented with an early onset of pulmonary hypertension, managed successfully with supportive care and systemic therapy directed toward the involution of infantile hepatic hemangioendothelioma.

Keywords: infantile hepatic hemangioendothelioma; persistent pulmonary hypertension of the newborn; propranolol; steroid.

Figures

Fig. 1
Fig. 1
Echocardiogram showing tricuspid regurgitation with peak jet velocity of 4.4 m/sec.
Fig. 2
Fig. 2
Liver magnetic resonance imaging showing T2-weighted image, and pre- and post-gadolinium contrast T1-weighted images.

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