Narrow-band imaging versus white light for the detection of proximal colon serrated lesions: a randomized, controlled trial
Douglas K Rex, Ryan Clodfelter, Farrah Rahmani, Hala Fatima, Toyia N James-Stevenson, John C Tang, Hak Nam Kim, Lee McHenry, Charles J Kahi, Nicholas A Rogers, Debra J Helper, Sashidhar V Sagi, William R Kessler, John M Wo, Monika Fischer, Paul Y Kwo, Douglas K Rex, Ryan Clodfelter, Farrah Rahmani, Hala Fatima, Toyia N James-Stevenson, John C Tang, Hak Nam Kim, Lee McHenry, Charles J Kahi, Nicholas A Rogers, Debra J Helper, Sashidhar V Sagi, William R Kessler, John M Wo, Monika Fischer, Paul Y Kwo
Abstract
Background: The value of narrow-band imaging (NBI) for detecting serrated lesions is unknown.
Objective: To assess NBI for the detection of proximal colon serrated lesions.
Design: Randomized, controlled trial.
Setting: Two academic hospital outpatient units.
Patients: Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations.
Interventions: Randomization to colon inspection in NBI versus white-light colonoscopy.
Main outcome measurements: The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon.
Results: The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups.
Limitations: Lack of blinding, endoscopic estimation of polyp location.
Conclusion: NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. (
Clinical trial registration number: NCT01572428.).
Copyright © 2016 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
Source: PubMed