Comparative in vitro efficacies of various catheter lock solutions

Abstract

MEDTA (minocycline-edetate calcium disodium), taurolidine (2%)-polyvinylpyrolidine (5%) (T/PVP), and ethanol as potential catheter lock solutions have a unique mechanism of action, broad-spectrum activity, and anticoagulant properties. Traditional lock solutions minocycline (M), rifampin (R), ciprofloxacin (C), and vancomycin, except pharmacologic concentrations of C and R and of M and R, were less effective than MEDTA and T/PVP.

Figures

FIG. 1.

Effects of therapeutic concentrations of antibiotic lock solutions on the growth of S. aureus (A) and C. albicans (B). M, minocycline; C, ciprofloxacin; V, vancomycin; R, rifampin; M + R, minocycline plus rifampin; C + R, ciprofloxacin plus rifampin; V + R, vancomycin plus rifampin.

FIG. 2.

Effects of pharmacologic concentrations of antibiotic lock solutions on the growth of S. aureus (A), S. epidermidis (B), P. aeruginosa (C), and C. albicans (D). M, minocycline; C, ciprofloxacin; V, vancomycin; R, rifampin; M + R, minocycline plus rifampin; C + R, ciprofloxacin plus rifampin; V + R, vancomycin plus rifampin; T 2%, PVP 5%, 2% taurolidine-5% polyvinylpyrolidine; MEDTA, minocycline-edetate calcium disodium.