One-year strabismus outcomes in the Infant Aphakia Treatment Study

Erick D Bothun, Julia Cleveland, Michael J Lynn, Stephen P Christiansen, Deborah K Vanderveen, Dan E Neely, Stacey J Kruger, Scott R Lambert, Infant Aphakic Treatment Study, Scott R Lambert, Lindreth Dubois, Michael Lynn MS, Betsy Bridgman, Marianne Celano, Julia Cleveland, George Cotsonis, Carey Drews-Botsch, Nana Freret, Lu Lu, Seegar Swanson, Thandeka Tutu-Gxashe, E Eugenie Hartmann, Clara Edwards, Claudio Busettini, Samuel Hayley, Scott R Lambert, Edward G Buckley, David A Plager, M Edward Wilson, Michael Lynn, Lindreth Dubois, Carolyn Drews-Botsch, E Eugenie Hartmann, Donald F Everett, Buddy Russell, Michael Ward, M Edward Wilson, Margaret Bozic, Deborah K Vanderveen, Theresa A Mansfield, Kathryn Bisceglia Miller, Stephen P Christiansen, Erick D Bothun, Ann Holleschau, Jason Jedlicka, Patricia Winters, Jacob Lang, Elias I Traboulsi, Susan Crowe, Heather Hasley Cimino, Kimberly G Yen, Maria Castanes, Alma Sanchez, Shirley York, David T Wheeler, Ann U Stout, Paula Rauch, Kimberly Beaudet, Pam Berg, Scott R Lambert, Amy K Hutchinson, Lindreth Dubois, Rachel Robb, Marla J Shainberg, Edward G Buckley, Sharon F Freedman, Lois Duncan, B W Phillips, John T Petrowski, David Morrison, Sandy Owings COA, Ron Biernacki CO, Christine Franklin, David A Plager, Daniel E Neely, Michele Whitaker, Donna Bates, Dana Donaldson, Stacey Kruger, Charlotte Tibi, Susan Vega, David R Weakley, David R Stager Jr, Joost Felius, Clare Dias, Debra L Sager, Todd Brantley, Robert Hardy, Eileen Birch, Ken Cheng, Richard Hertle, Craig Kollman, Marshalyn Yeargin-Allsopp, Cyd McDowell, Donald F Everett, Allen Beck, Erick D Bothun, Julia Cleveland, Michael J Lynn, Stephen P Christiansen, Deborah K Vanderveen, Dan E Neely, Stacey J Kruger, Scott R Lambert, Infant Aphakic Treatment Study, Scott R Lambert, Lindreth Dubois, Michael Lynn MS, Betsy Bridgman, Marianne Celano, Julia Cleveland, George Cotsonis, Carey Drews-Botsch, Nana Freret, Lu Lu, Seegar Swanson, Thandeka Tutu-Gxashe, E Eugenie Hartmann, Clara Edwards, Claudio Busettini, Samuel Hayley, Scott R Lambert, Edward G Buckley, David A Plager, M Edward Wilson, Michael Lynn, Lindreth Dubois, Carolyn Drews-Botsch, E Eugenie Hartmann, Donald F Everett, Buddy Russell, Michael Ward, M Edward Wilson, Margaret Bozic, Deborah K Vanderveen, Theresa A Mansfield, Kathryn Bisceglia Miller, Stephen P Christiansen, Erick D Bothun, Ann Holleschau, Jason Jedlicka, Patricia Winters, Jacob Lang, Elias I Traboulsi, Susan Crowe, Heather Hasley Cimino, Kimberly G Yen, Maria Castanes, Alma Sanchez, Shirley York, David T Wheeler, Ann U Stout, Paula Rauch, Kimberly Beaudet, Pam Berg, Scott R Lambert, Amy K Hutchinson, Lindreth Dubois, Rachel Robb, Marla J Shainberg, Edward G Buckley, Sharon F Freedman, Lois Duncan, B W Phillips, John T Petrowski, David Morrison, Sandy Owings COA, Ron Biernacki CO, Christine Franklin, David A Plager, Daniel E Neely, Michele Whitaker, Donna Bates, Dana Donaldson, Stacey Kruger, Charlotte Tibi, Susan Vega, David R Weakley, David R Stager Jr, Joost Felius, Clare Dias, Debra L Sager, Todd Brantley, Robert Hardy, Eileen Birch, Ken Cheng, Richard Hertle, Craig Kollman, Marshalyn Yeargin-Allsopp, Cyd McDowell, Donald F Everett, Allen Beck

Abstract

Objective: To evaluate the characteristics of strabismus in infants who underwent cataract surgery with and without intraocular lens (IOL) implantation.

Design: Secondary outcome analysis in a prospective, randomized clinical trial.

Participants: The Infant Aphakia Treatment Study is a randomized, multicenter (n = 12), clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with a unilateral congenital cataract.

Intervention: Infants underwent cataract surgery with or without placement of an IOL.

Main outcome measures: The proportion of patients in whom strabismus developed during the first 12 months of follow-up was calculated using the life-table method and was compared across treatment groups and age strata using a log-rank test.

Results: Strabismus developed within the first 12 months of follow-up in 38 pseudophakic infants (life-table estimate, 66.7%) and 42 infants (life-table estimate, 74.5%) treated with contact lenses (P = 0.59). The younger cohort (<49 days) at the time of surgery demonstrated less strabismus (29 of 50; life-table estimate, 58.0%) than the older cohort (≥ 49 days; 51 of 64; life-table estimate, 80.0%; P<0.01).

Conclusions: Intraocular lens placement does not prevent the early development of strabismus after congenital cataract surgery. However, strabismus was less likely to develop in infants whose cataract was removed at an earlier age.

Financial disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.