PROOF: PROtein OverFeeding Effect on Body Weight (PROOF)

Inclusion Criteria:

• Have a BMI of 19-30kg/m2 A cutpoint of 26kg/m2 will be used to allocate treatment across the three diets. See the statistics section for more detail.
• Are willing to eat all of the study foods even when full
• Are willing to eat only foods provided by Pennington and all of the foods provided
• Are willing to live at Pennington for 10-12 weeks possibly without leaving the metabolic unit the entire time
• Are willing to avoid exercise while in the inpatient phase of the study
• Age 18 - 35

Exclusion Criteria:

Participants are ineligible to participate in the study if they…

• Smoke
• Have Diabetes
• Have claustrophobia
• Have a Fasting Blood Sugar >110
• Have a history of cardiovascular disease
• Have an average screening blood pressure >140/90
• Have a history of a major psychiatric, addictive or eating disorder or any psychosocial or scheduling factors that could impede study outcomes
• Post obese (self-reported BMI) must never have had a BMI greater than 32
• Exercise more than 2 hours per week
• Unable to complete VO2 max test.
• Weight gain or loss of > 3kg in the last 6 months
• Have significant renal, hepatic, endocrine, pulmonary or hematological disease, or a history of gout
• Have had previous GI surgery, Obstructive disease of the GI tract, Hypermotility disorder or a history of problems of impairment of the gag reflex.
• Corticosteroid use in the last 2 Months
• You are pregnant or breastfeeding
• Have Irregular menstrual cycles
• Use Depo-Provera, hormone implant or estrogen replacement therapy
• Have an allergy to PABA (a component of a B-vitamin often found in sunscreen)