Correlation of Pain, Obesity and Fertility Potential.
Obesity, Pain and Fertility: is There Any Association?
Studieöversikt
Status
Betingelser
Detaljerad beskrivning
Obesity is associated with several disorders including chronic musculoskeletal pain. For example obesity has been implicated in the development or progression of low back pain and knee osteoarthritis. The mechanism by which obesity causes lumbar back pain is poorly understood, but the contribution of both mechanical and system factors is likely. Direct mechanical stress on the intervertebral discs and adjacent structures are suspected to be mechanisms through which obesity affects the spine, leading to subsequent low back pain. The link between obesity and knee osteoarthritis has also been demonstrated, but potential factors underlying the association of obesity with knee osteoarthritis has not entirely been elucidated.
It is a well-known fact that obesity leads to an excess load on the joint, increased cartilage turnover, increased collagen type 2 degradation products and increased risk of degenerative meniscal lesions. Although all of these factors have been proposed to lead to knee osteoarthritis, no causal relationship has been demonstrated.
Studietyp
Inskrivning (Förväntat)
Kontakter och platser
Studieorter
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Aalborg, Danmark, DK-9000
- Rekrytering
- Clinic for Neuro- and Orthopaedic Diseases, Aalborg University Hospital
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Kontakt:
- Sten Rasmussen, M.D.
- E-post: sten.rasmussen@rn.dk
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Underutredare:
- Fereshteh Dardmeh, PhD stud.
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Huvudutredare:
- Sten Rasmussen, M.D
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Huvudutredare:
- Hans I. Nielsen, PhD, MSc
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Underutredare:
- Parisa Gazerani, PhD
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Underutredare:
- Hiva Alipour, PhD stud.
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Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Testmetod
Studera befolkning
Beskrivning
Inclusion Criteria:
- Men between 18-45 years with low back pain or knee pain recruited among referees to the orthopaedic outpatient clinics at Aalborg University Hospital
- Pain more than 3 months
- Patients can be on a daily use of Paracetamol 1 gram x 4, NSAID x 3-4 or combined
- Patients will be included regardless of their BMI but will be put in their respective BMI subgroup after the required measurements have been taken
- Regarding low back pain the LBPRS >9, knee pain the KOOS <75 (0-100, i.c. 100 = no problems)
- Healthy men in the age 18-45 years (matched with enrolled patients)
Exclusion Criteria:
- Malignancy
- Ongoing infection
- Drug addiction defined as the use of cannabis, opioids or other psycho drugs
- Previous neurologic, musculoskeletal or mental diseases
- Lack of ability to cooperate
- Pain rating
- Patients with a pain rate below 3
- Medication
- Patients taking Morphine drugs
Studieplan
Hur är studien utformad?
Designdetaljer
- Observationsmodeller: Case-Control
- Tidsperspektiv: Retrospektiv
Kohorter och interventioner
Grupp / Kohort |
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Group I
Overweight osteoarthritis patients
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Group II
Normal weight osteoarthritis patients.
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Group III
Overweight healthy men.
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Group IV
Normal weight healthy men.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Progressive motility
Tidsram: 6 months
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Progressive motility as in the world health organization lower reference limits for sperm quality.
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6 months
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Pain
Tidsram: 6 months
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The patients will be tested for their pain in terms of intensity and quality.
Intensity will be rated on a visual analogue scale (VAS 0-10) for ongoing pain.
Pressure pain will be measured by application of a handheld pressure algometer.
A validated Danish version of short form McGill Pain Questionnaire will be given to evaluate the quality of pain.
In addition, distribution of pain will be mapped by drawing on a body chart.
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6 months
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Samarbetspartners och utredare
Samarbetspartners
Utredare
- Studierektor: Sten Rasmussen, M.D., Clinic for Neuro- and Orthopaedic Diseases, Aalborg University Hospital
- Studierektor: Hans I. Nielsen, PhD, Department of Health Science and Technology, Aalborg University
- Huvudutredare: Fereshteh Dardmeh, PhD stud., Department of Health Science and Technology, Aalborg University
- Studiestol: Parisa Gazerani, PhD, Department of Health Science and Technology, Aalborg University
- Studiestol: Hiva Alipour, PhD stud., Department of Health Science and Technology, Aalborg University
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Förväntat)
Avslutad studie (Förväntat)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- N-20140025
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