Impact of Bariatric Surgery on Cardiorespiratory Function
Impact of Bariatric Surgery on Cardiorespiratory Function: an Observational Study
Obesity is a growing problem worldwide and its prevention has become one of the leading priorities for the World Health Organisation. Obesity results from chronic imbalance between energy intake and energy expenditure. Although early prevention of obesity is preferable, surgical treatment is often required for severely obese people.
Bariatric surgery has been shown to be the most effective therapy for severe obesity. Weight loss following bariatric surgery results in significant improvements in coexisting comorbidities, such as diabetes and hypertension but there is controversy whether bariatric surgery also improves aerobic capacity.
The purpose of this study is to investigate the effects of bariatric surgery on cardiopulmonary function and on daily physical activity. It is hypothesized that bariatric surgery will improve aerobic capacity and result in beneficial lifestyle changes from sedentary to more active.
Studieöversikt
Status
Betingelser
Studietyp
Inskrivning (Förväntat)
Kontakter och platser
Studieorter
-
-
-
London, Storbritannien, SW17 0RE
- Rekrytering
- St George's Healthcare NHS Trust
-
Kontakt:
- Dimitra Nikoletou
- Telefonnummer: +44 20 8725 5647
- E-post: dinikole@sgul.ac.uk
-
Underutredare:
- Emma R McGlone
-
Underutredare:
- Ommar A Khan
-
-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Testmetod
Studera befolkning
Beskrivning
Inclusion Criteria:
- Ages 18 years to 50 years
- Patients enrolled in the bariatric surgery program of St George's Hospital with BMI > 40 kg/m2, or 35-40 kg/m2 in the presence of other obesity-related comorbidities such as hypertension or type- 2 diabetes
Exclusion Criteria:
- Locomotor difficulties which would prevent participants from completing the cardiopulmonary exercise testing
- Weight > 190 kg (due to weight restrictions of equipment used to transfer patients in the event of medical emergencies)
- Cognitive impairment
- Patients unable to follow instructions in English
Studieplan
Hur är studien utformad?
Designdetaljer
Vad mäter studien?
Primära resultatmått
Resultatmått |
Tidsram |
|---|---|
|
Cardiorespiratory function assessed by peak oxygen consumption (VO2peak)
Tidsram: One to two weeks before surgery and six months after surgery
|
One to two weeks before surgery and six months after surgery
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Lung function
Tidsram: One to two weeks before surgery and six months after surgery
|
Lung function will be assessed by spirometry and body plethysmography
|
One to two weeks before surgery and six months after surgery
|
|
Heart function
Tidsram: One to two weeks before surgery and six months after surgery
|
Echocardiography will be performed to assess heart function.
|
One to two weeks before surgery and six months after surgery
|
|
Inspiratory muscle strength
Tidsram: One to two weeks before surgery and six months after surgery
|
Maximal inspiratory pressure and sniff nasal pressure will be recorded.
|
One to two weeks before surgery and six months after surgery
|
|
Peripheral muscle strength
Tidsram: One to two weeks before surgery and six months after surgery
|
Maximum isometric strength of hand/ forearm, quadriceps and hip flexors muscles will be evaluated
|
One to two weeks before surgery and six months after surgery
|
|
Free living sedentary and physical activity times
Tidsram: One to two weeks before surgery and six months after surgery
|
Daily physical activity habits will be assessed by an accelerometer and International Physical Activity Questionnaire: Long (IPAQ-Long).
Participants will be required to wear the accelerometer for four consecutive days during the two study points.
|
One to two weeks before surgery and six months after surgery
|
Samarbetspartners och utredare
Samarbetspartners
Utredare
- Huvudutredare: Marcia S Volpe, Universidade Federal Triangulo Mineiro
- Studiestol: Dimitra Nikoletou, Kingston University and St George's University of London
- Studierektor: Marcus Reddy, St George's Healthcare NHS Trust
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Förväntat)
Avslutad studie (Förväntat)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- 13.0217
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .