Sensitivity of an Upper Limb Motion Analysis Protocol to Changes in Kinematics and Muscle Activity After Constraint Induced Therapy in Children With Hemiplegia (MouvsupTCIHemi)
10 september 2026 uppdaterad av: Nantes University Hospital
Quantified Analysis of the Movements of the Upper Limb of Children With Hemiparesis Participating in the Stress Induced Therapy Program
In France, Cerebral Palsy (CP) affects 1 in 450 births.
It results from lesions of the brain, before, during, or shortly after birth.
These non-progressive lesions cause muscle impairments, responsible for activity limitations.
These muscle impairments include muscle stiffness, and muscle weakness.
Children with Unilateral CP (UCP) have these impairments on only one side of the body.
To compensate for activity limitations with their impaired arm, these children over-use their non-impaired arm.
The objective of constraint-induced therapy (CIT) is to minimize this asymmetry which deteriorates mobility on the impaired side, by forcing the child to only use its impaired arm several hours a day during several weeks of therapy.
It is known using clinical tests that this therapy improves the overall motor function of the impaired arm.
However, the underlying mechanisms are yet unknown.
An understanding of these mechanisms would suggest ways to maximize the effectiveness of this therapy, which requires a significant commitment from the child and its family.
The investigaors propose in this project a quantitative and objective evaluation of the effect of CIT on the movements of the impaired arm of children with UCP.
The investogators focus their analysis on muscle activation, to assess which aspect of muscle impairments is modified by CIT.
To this end, the investigators will use sensors identical to those already used in clinics for the Quantified Gait Analysis of children with CP, recognized since 2006 by the Haute Autorité de Santé as providing key supplementary data in the evaluation of complex gait disorders.
Results from this study will provide leads to optimize CIT.
Some children could for example benefit from CIT paired with treatments to reduce muscle stiffness or to strengthen muscles
Studieöversikt
Status
Avslutad
Betingelser
Intervention / Behandling
Detaljerad beskrivning
Quantitative and objective evaluation of upper limb movements will take place in a motion analysis laboratory and will take place as follow:
- A clinical exam of the participant will be performed by the physician to collect maximal passive joint amplitudes with a goniometer and anatomical measures (length, circumference) of the upper limb.
- The participant will be equipped with surface electromyographic electrodes to measure the activation of his superficial muscles, and with retroreflective markers placed on anatomical landmarks of his thorax, shoulder, and arm, to measure upper limb kinematics with a 3D motion capture system composed of 8 VICON cameras.
- Maximal forces of elbow pronosupination and flexion-extension will be measured with a portable dynamometer.
The participant will be placed on a height adjustable bench, in the center of the laboratory. He will be asked to perform upper limb movements:
- A few movements not measured, to familiarize with the equipment;
- Recorded movements: a trial is composed of a few consecutive cycles of a movement such as elbow flexion-extension. A trial usually last about 10seconds. A few seconds-time of rest is imposed between each trial. The required movements are the following: elbow flexion-extension, elbow pronosupination, and "hand to mouth".
- Finally, the participant will be asked to lie down on an exam table and to rest relax, in order to measure the electromyographic signal of his muscles at rest.
Duration of the protocol is about 1h30, with less than 30seconds of effort, and a few minutes of performing simple upper limb movements.
Studietyp
Interventionell
Inskrivning (Faktisk)
28
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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Nantes, Frankrike, 46208
- CHU de Nantes
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
6 år till 17 år (Barn)
Tar emot friska volontärer
Ja
Beskrivning
Inclusion Criteria:
- Participants (excluding healthy volunteers) must have hemiparesis.
- Children must be between 6 and 17 years of age. The protocol requires a minimum concentration difficult to obtain for children under 6 years.
- Participants must be enrolled in a health insurance plan.
Exclusion Criteria:
- Inability to understand or follow instructions during 1h30.
- Physical incapacity to carry out the requested movements
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Övrig
- Tilldelning: Icke-randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
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Övrig: A: Healthy volunteers
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Maximal forces of elbow pronosupination and flexion-extension will be measured with a portable dynamometer.
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Övrig: B: Patient with heamiplegia
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Maximal forces of elbow pronosupination and flexion-extension will be measured with a portable dynamometer.
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Övrig: C: Patient with heamiplegia and constraint induced therapy
arm with constraint induced therapy (done before the protocol)
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Maximal forces of elbow pronosupination and flexion-extension will be measured with a portable dynamometer.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Upper limb muscle activation envelopes
Tidsram: 5 weeks
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Muscle activation envelopes come from electromyographic signals of upper limb muscles.
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5 weeks
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kinematics during active movements
Tidsram: 5 weeks
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Kinematics: angles, velocities, accelerations of the thorax, shoulder, elbow and wrist in the three anatomical plans (sagittal, frontal, transverse).
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5 weeks
|
Samarbetspartners och utredare
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Sponsor
Publikationer och användbara länkar
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Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
28 mars 2017
Primärt slutförande (Faktisk)
17 april 2019
Avslutad studie (Faktisk)
17 april 2019
Studieregistreringsdatum
Först inskickad
20 mars 2017
Först inskickad som uppfyllde QC-kriterierna
28 mars 2017
Första postat (Faktisk)
4 april 2017
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
14 september 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
10 september 2026
Senast verifierad
1 juni 2019
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- RC15_0310
Läkemedels- och apparatinformation, studiedokument
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