The Effects of Losartan on Social Reward
21 oktober 2020 uppdaterad av: Benjamin Becker, University of Electronic Science and Technology of China
Losartan Effects on the Social Reward in Humans
The aim of the study is to investigate the effect of losartan (50mg, single dose) on social reward
Studieöversikt
Status
Okänd
Betingelser
Intervention / Behandling
Detaljerad beskrivning
In a double-blind, between-subject, placebo-controlled design the effects of a single dose of losartan (50mg) on social reward in healthy participants will be examined.
90 minutes after subjects administrate 50mg losartan or placebo, participants will undergo a social incentive delay task.
Neural activity will be assessed by the acquisition of functional magnetic resonance imaging (fMRI) data.
Studietyp
Interventionell
Inskrivning (Förväntat)
90
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
-
-
Sichuan
-
Chengdu, Sichuan, Kina, 611731
- Rekrytering
- University of Electronic Science and Technology of China
-
Kontakt:
- Weihua Zhao, PhD
- E-post: zarazhao.uestc@outlook.com
-
-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år till 30 år (Vuxen)
Tar emot friska volontärer
Ja
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
- Healthy subjects without past or current psychiatric or neurological disorders
Exclusion Criteria:
- history of head injury
- medical or psychiatric illness
- hypertension
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Grundläggande vetenskap
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Dubbel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: Losartan grupp
Läkemedel: Losartan
|
administration of losartan (50 mg) (oral)
Andra namn:
|
|
Placebo-jämförare: Placebogrupp
Läkemedel: Placebo oral tablett
|
administrering av placebo (oralt)
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Losartan effects on neural activity as assessed by blood oxygenation dependent (BOLD) fMRI during the anticipation of social feedback.
Tidsram: 90 minutes to 105 minutes after treatment
|
The social incentive delay task provides subjects with trial-wise feedback on their performance (as assessed by reaction time).
Neural activity will be measured by functional magnetic resonance imaging (fMRI).
To examine effects of treatment during the anticipation of social feedback fMRI-based neural indices during the anticipation period will be compared between the losartan and the placebo treated group using a Generalized Linear Model approach.
The analysis will focus on brain systems that play an important role in the anticipation of reward and punishment (prefrontal cortex and subcortical regions, including the striatum)
|
90 minutes to 105 minutes after treatment
|
|
Losartan effects on neural activity as assessed by blood oxygenation dependent (BOLD) fMRI during the consummation of social feedback.
Tidsram: 90 minutes to 105 minutes after treatment
|
The social incentive delay task provides subjects with trial-wise feedback on their performance (as assessed by reaction time).
Following each trial the feedback will be indicated by positive and negative social stimuli.
Neural activity will be measured by functional magnetic resonance imaging (fMRI).
To examine effects of treatment during the consummation of social feedback fMRI-based neural indices during the presentation of the feedback will be compared between the losartan and the placebo treated group using a Generalized Linear Model approach.
The analysis will focus on brain systems that play an important role in reward and punishment (prefrontal cortex and subcortical regions, including the striatum)
|
90 minutes to 105 minutes after treatment
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Effects of Losartan on arousal ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
Tidsram: 150 minutes to 160 minutes after treatment
|
Following the fMRI assessment participants will be asked to rate the arousal of the stimuli presented during fMRI.
Arousal will be assessed on 1-9 Likert rating scales.
To examine effects of treatment on arousal ratings the losartan and placebo groups will be compared using Generalized Linear Model approach.
|
150 minutes to 160 minutes after treatment
|
|
Effects of Losartan on valence ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
Tidsram: 150 minutes to 160 minutes after treatment
|
Following the fMRI assessment participants will be asked to rate the valence of the stimuli presented during fMRI.
Valence will be assessed on 1-9 Likert rating scales.
To examine effects of treatment on valence ratings the losartan and placebo groups will be compared using Generalized Linear Model approach.
|
150 minutes to 160 minutes after treatment
|
|
Effects of Losartan on intensity ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
Tidsram: 150 minutes to 160 minutes after treatment
|
Following the fMRI assessment participants will be asked to rate the intensity of the stimuli presented during fMRI.
Intensity will be assessed on 1-9 Likert rating scales.
To examine effects of treatment on intensity ratings the losartan and placebo groups will be compared using Generalized Linear Model approach.
|
150 minutes to 160 minutes after treatment
|
|
Effects of Losartan on likeability ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
Tidsram: 150 minutes to 160 minutes after treatment
|
Following the fMRI assessment participants will be asked to rate the likeability of the stimuli presented during fMRI.
Likeability will be assessed on 1-9 Likert rating scales.
To examine effects of treatment on likeability ratings the losartan and placebo groups will be compared using Generalized Linear Model approach.
|
150 minutes to 160 minutes after treatment
|
|
Effects of Losartan on dislikeability ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
Tidsram: 150 minutes to 160 minutes after treatment
|
Following the fMRI assessment participants will be asked to rate the dislikeability of the stimuli presented during fMRI.
Dislikeability will be assessed on 1-9 Likert rating scales.
To examine effects of treatment on dislikeability ratings the losartan and placebo groups will be compared using Generalized Linear Model approach.
|
150 minutes to 160 minutes after treatment
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Utredare
- Huvudutredare: Benjamin Becker, PhD, University of Electronic Science and Technology of China
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
10 oktober 2020
Primärt slutförande (Förväntat)
31 december 2021
Avslutad studie (Förväntat)
31 mars 2022
Studieregistreringsdatum
Först inskickad
9 oktober 2020
Först inskickad som uppfyllde QC-kriterierna
21 oktober 2020
Första postat (Faktisk)
27 oktober 2020
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
27 oktober 2020
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
21 oktober 2020
Senast verifierad
1 oktober 2020
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- UESTC-neuSCAN-72
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
NEJ
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Nej
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
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