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A Study of Nivolumab in Participants With Squamous Cell Carcinoma of the Head & Neck (SCCHN) - Patient Reported Outcomes (PRO) (VOLUME-PRO)

2 maj 2022 uppdaterad av: Bristol-Myers Squibb

Nivolumab in the Real World in Patients With Squamous Cell Carcinoma of the Head & Neck (SCCHN) - Patient Reported Outcomes (PRO)

The purpose of the study is to capture the utilization of nivolumab among participants with squamous cell carcinoma of the head and neck (SCCHN) since its approval, and to describe the health related quality of life (HRQoL) among participants treated with nivolumab in a real-world setting.

Studieöversikt

Status

Avslutad

Betingelser

Intervention / Behandling

Detaljerad beskrivning

This is a phase 4 prospective chart review study with patient reported outcome (PRO) administration. The study population consists of participants diagnosed with squamous cell carcinoma of the head and neck (SCCHN) and are being treated with nivolumab. Eligible participants will be enrolled and observed from enrollment up to eight weeks. Demographic and clinical characteristics will be collected at enrollment. PROs will be administered at enrollment and again at a follow-up standard of care visit approximately eight weeks after enrollment.

Studietyp

Observationell

Inskrivning (Faktisk)

509

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studieorter

  • Förenta staterna
    • New Jersey
      • Mount Laurel, New Jersey, Förenta staterna, 08054
        • Local Institution

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

18 år och äldre (Vuxen, Äldre vuxen)

Tar emot friska volontärer

Nej

Kön som är behöriga för studier

Allt

Testmetod

Icke-sannolikhetsprov

Studera befolkning

The population for this study will be approximately 50 adult participants, with a diagnosis of recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) currently being treated with nivolumab in the United Kingdom, Switzerland, Spain, or Canada. The study population will include participants with available data from medical records at enrollment who are willing to complete patient reported outcome (PRO) assessments.

Beskrivning

Inclusion Criteria:

  • Diagnosis of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN)
  • Age ≥18 years at time of nivolumab treatment initiation
  • Investigator has decided that nivolumab is appropriate therapy and the participant had received at least one administration of nivolumab for the treatment of recurrent/metastatic SCCHN prior to enrolment in the study
  • Charts/records include treatment start date of nivolumab
  • Provide consent and is willing to self-complete on-site patient reported outcomes (PROs) on at least one occasion

Exclusion Criteria:

  • Currently enrolled in an interventional clinical trial for their SCCHN
  • Received systemic treatment for any other primary cancer within 6 months of study enrolment

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

  • Observationsmodeller: Kohort
  • Tidsperspektiv: Blivande

Kohorter och interventioner

Grupp / Kohort
Intervention / Behandling
Cohort 1
Participants with squamous cell carcinoma of the head and neck (SCCHN) treated with nivolumab
Biologisk: Nivolumab
Participants in this study are being treated with nivolumab for SCCHN
Andra namn:
  • Opdivo®, BMS-936558

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Distribution of demographic characteristics of R/M SCCHN participants treated with nivolumab: Month and year of birth
Tidsram: At enrollment
Recurrent/Metastatic (R/M) Squamous Cell Carcinoma of the Head & Neck (SCCHN)
At enrollment
Distribution of demographic characteristics of R/M SCCHN participants treated with nivolumab: Sex
Tidsram: At enrollment
At enrollment
Distribution of demographic characteristics of R/M SCCHN participants treated with nivolumab: Race/ethnicity
Tidsram: At enrollment
At enrollment
Distribution of demographic characteristics of R/M SCCHN participants treated with nivolumab: Smoking status
Tidsram: At enrollment
At enrollment
Distribution of clinical characteristics of R/M SCCHN participants treated with nivolumab: Primary tumor location
Tidsram: At enrollment
At enrollment
Distribution of clinical characteristics of R/M SCCHN participants treated with nivolumab: Metastasis locations
Tidsram: At enrollment
At enrollment
Distribution of clinical characteristics of R/M SCCHN participants treated with nivolumab: Histology
Tidsram: At enrollment
At enrollment
Distribution of clinical characteristics of R/M SCCHN participants treated with nivolumab: Date of diagnosis of R/M SCCHN
Tidsram: At enrollment
At enrollment
Distribution of clinical characteristics of R/M SCCHN participants treated with nivolumab: Stage at locally advanced/metastatic SCCHN diagnosis
Tidsram: At enrollment
At enrollment
Distribution of patterns of use of nivolumab treatment in participants with R/M SCCHN: Duration of nivolumab therapy
Tidsram: Up to 8 weeks following enrollment
Up to 8 weeks following enrollment
Distribution of patterns of use of nivolumab treatment in participants with R/M SCCHN: Drug discontinuation
Tidsram: Up to 8 weeks following enrollment
Up to 8 weeks following enrollment
Distribution of doses of nivolumab therapy in participants with R/M SCCHN
Tidsram: Up to 8 weeks following enrollment
Up to 8 weeks following enrollment
Distribution of subsequent treatment in participants discontinuing nivolumab
Tidsram: Up to 8 weeks following enrollment
Up to 8 weeks following enrollment
Distribution of patient reported health-related quality of life (HRQoL) measures through European Organisation for Research and Treatment of Cancer Quality of Life- Core Questionnaire in participants treated with nivolumab for R/M SCCHN
Tidsram: At enrollment, Up to 8 weeks
At enrollment, Up to 8 weeks
Distribution of patient reported HRQoL measures through EQ-5D-5L in participants treated with nivolumab for R/M SCCHN
Tidsram: At enrollment, Up to 8 weeks
At enrollment, Up to 8 weeks
Distribution of patient reported HRQoL measures through European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module in participants treated with nivolumab for R/M SCCHN
Tidsram: At enrollment, Up to 8 weeks
At enrollment, Up to 8 weeks
Distribution of patient reported HRQoL measures through CTSQ in participants treated with nivolumab for R/M SCCHN
Tidsram: At enrollment, Up to 8 weeks
Cancer Therapy Satisfaction Questionnaire (CTSQ)
At enrollment, Up to 8 weeks
Distribution of patient reported HRQoL measures through WPAI:GH in participants treated with nivolumab for R/M SCCHN
Tidsram: At enrollment, Up to 8 weeks
Work Productivity and Activity Impairment Questionnaire: General Health (WPAI:GH)
At enrollment, Up to 8 weeks

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Sponsor

Bristol-Myers Squibb

Publikationer och användbara länkar

Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.

Användbara länkar

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

13 augusti 2020

Primärt slutförande (Faktisk)

18 oktober 2021

Avslutad studie (Faktisk)

18 oktober 2021

Studieregistreringsdatum

Först inskickad

8 september 2021

Först inskickad som uppfyllde QC-kriterierna

24 september 2021

Första postat (Faktisk)

6 oktober 2021

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

5 maj 2022

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

2 maj 2022

Senast verifierad

1 maj 2022

Mer information

Termer relaterade till denna studie

Nyckelord

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

  • CA209-7F9

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