流行病学和肺对有机粉尘暴露的反应
研究概览
详细说明
背景:
1986 年研究开始时,农业是美国最大的雇主之一,有将近 1200 万人。 农场工人比其他职业群体更频繁地住院,并且被发现因受伤和疾病而限制活动的天数最多。 这在很大程度上是由于与农场有关的频繁和致残事故,这使农业成为美国最危险的职业。 根据社会保障残疾记录,与其他工业部门相比,农业工人的呼吸系统残疾率也很高。
农业工人呼吸系统疾病的共同点是接触有机粉尘,有机粉尘被认为是植物颗粒和碎片、微生物及其产品、昆虫和昆虫碎片、包括鱼粉和抗生素在内的饲料添加剂以及鸟类和啮齿动物的复杂混合物蛋白质。 虽然植物粉尘本身是迄今为止最重要的暴露,但产生有机粉尘的产品的生长、储存和后续使用的个别情况影响了特定的暴露。 在某些情况下,如动物禁闭室,包括氨和硫化氢在内的刺激性气体与有机粉尘共存,进一步改变呼吸暴露。
众所周知,在爱荷华州养猪场工作的工人会大量接触谷物粉尘、内毒素、动物皮屑和其他蛋白质、氨气和硫化氢气体,以及包括真菌和嗜热放线菌在内的各种微生物。 横断面流行病学调查记录了呼吸道症状的高发率,包括慢性咳嗽、痰和喘息,以及突出的全身症状,包括发烧、肌痛和不适。 这项研究是职业和免疫性肺病专业研究中心支持的几个项目之一。
资金约占职业和免疫性肺病专业研究中心 (P50HL37121) 用于支持流行病学研究的资金的 35%。
设计叙述:
对先前研究的队列进行了巢式病例对照研究。 该队列的成员在研究的第一年进行了重新调查。 所有参与者都接受了常规体检、胸部 X 光检查、40 岁以上的心电图、常规实验室检查、乙酰甲胆碱激发试验、皮内皮肤试验和支气管肺泡灌洗。 如果 FEF50 为年龄、性别、身高和种族预测值的 60% 或更低,则选择猪圈养农民队列的病例。 每个案例的三个参考对象是从所有未被选为案例的猪圈养农民、非圈养农民和蓝领工人中随机选择的。 在第四年重复测量,在研究的第五年结束。 该研究确定: 流行病学研究在多大程度上低估了农业工人的肺部反应和损伤;与案件显着相关的环境风险因素;特应性和气道反应性升高是否与危险因素显着相关。 该子项目于 1992 年没有续期。
本记录中列出的研究完成日期是从旧格式协议注册和结果系统 (PRS) 中输入的“结束日期”获得的。
研究类型
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
学习计划
研究是如何设计的?
合作者和调查者
出版物和有用的链接
一般刊物
- Merchant JA: Agricultural Respiratory Disease, In: Seminars in Respiratory Medicine - Vol. 7, Number 3. Thieme Inc, pp 211-224, New York, 1986
- Merchant JA: Silicosis Issues - Past, Present, Future. Published in Book: Silica, Silicosis, and Cancer: Controversy in Occupational Medicine, 1986, Goldsmith DF, Winn DM, Shy CM (Eds), Praeger Special Studies, Praeger Scientific, pp 87-90, New York, 1986
- Omenn GS, Merchant J, Boatman E, Dement JM, Kuschner M, Nicholson W, Peto J, Rosenstock L. Contribution of environmental fibers to respiratory cancer. Environ Health Perspect. 1986 Dec;70:51-6. doi: 10.1289/ehp.867051.
- Merchant JA. Preparing for disaster. Am J Public Health. 1986 Mar;76(3):233-5. doi: 10.2105/ajph.76.3.233. No abstract available.
- Merchant JA: Contribution to Report The Health Consequences of Smoking: Cancer and Chronic Lung Disease in the Workplace: A Report of the Surgeon General. U.S. Department of Health and Human Services, Public Health Service, Office on Smoking and Health, U.S. Government Printing Service, Washington, D.C., 1986
- Merchant JA, Boehlecke BA, Taylor G (EDs): Occupational Respiratory Diseases, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, U.S. Government Printing Office, Washington, D.C., 1986
- Dement JM, Merchant JA: Chapter III. C: Asbestosis, in Occupational Respiratory Diseases, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, U.S. Government Printing Office, Washington, D.C., 1986
- Merchant JA: Chapter VI. Byssinosis, in Occupational Respiratory Diseases, U.S. Department of Health and Human Services, Public Health Services, Centers for Disease Control, National Institute for Occupational Safety and Health, U.S. Government Printing Office, Washington, D.C., 1986
- Merchant JA, Hodous T, Taylor G, Reger R: Chapter III. D: Coal Workers Pneumoconiosis, in Occupational Respiratory Diseases, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, U.S. Government Printing Office, Washington, D.C., 1986
- Merchant JA. New dimensions in occupational medicine. Iowa Med. 1987 Apr;77(4):177-9. No abstract available.
- Merchant JA. Agricultural exposures to organic dusts. Occup Med. 1987 Apr-Jun;2(2):409-25.
- Muldoon JT, Wintermeyer LA, Eure JA, Fuortes L, Merchant JA, Van Lier SF, Richards TB. Occupational disease surveillance data sources, 1985. Am J Public Health. 1987 Aug;77(8):1006-8. doi: 10.2105/ajph.77.8.1006.
- Merchant JA, Donham KJ: Health Risks from Animal Confinement Units. Proceedings of the International Symposium on Health and Safety in Agriculture. Saskatoon, Canada. In press, 1987
- Guernsey JR, Morgan DP, Marx JJ, Horvath EP, Pierce P, Merchant JA: The Prognostic Significance of Farmer's Lung Disease Antibodies Relative to Measures of Respiratory Disease. Proceedings of the International Symposium on Health and Safety in Agriculture, Saskatoon, Canada. In press, 1987
- Leistikow BN, Donham KJ, Merchant JA: Health Hazards of Poultry Production: Proceedings of the International Symposium on Health and Safety in Agriculture, Saskatoon, Canada. In press, 1987
- Twiggs JT, Gray RL, Marx JJ Jr. House dust mite (Dermatophagoides farinae) allergen levels in three different sources from homes of patients with allergy to house dust mite. Clin Rev Allergy. 1988 Spring;6(1):35-43. doi: 10.1007/BF02914980. No abstract available.
- Merchant JA: Occupational Parenchymal Lung Disease. Kelley: Textbook of Internal Medicine. In press, 1988
- LaMarte FP, Merchant JA, Casale TB. Acute systemic reactions to carbonless copy paper associated with histamine release. JAMA. 1988 Jul 8;260(2):242-3.
- Schwartz DA, Galvin JR, Dayton CS, Stanford W, Merchant JA, Hunninghake GW. Determinants of restrictive lung function in asbestos-induced pleural fibrosis. J Appl Physiol (1985). 1990 May;68(5):1932-7. doi: 10.1152/jappl.1990.68.5.1932.
- Donham KJ, Merchant JA, Lassise D, Popendorf WJ, Burmeister LF. Preventing respiratory disease in swine confinement workers: intervention through applied epidemiology, education, and consultation. Am J Ind Med. 1990;18(3):241-61. doi: 10.1002/ajim.4700180303.
- Merchant JA, Donham KJ, Popendorf WJ, Burmeister LF, Lassise DG, Lee NF, Weinrich AJ: Acute Responses Among Swine Confinement Workers. Proceedings of Agricultural, Occupational, and Environmental Health: Health Policy Strategies for the Future. Iowa City, Iowa. In press 1988
- Schwartz DA, Landas SK, Lassise DL, Burmeister LF, Hunninghake GW, Merchant JA. Airway injury in swine confinement workers. Ann Intern Med. 1992 Apr 15;116(8):630-5. doi: 10.7326/0003-4819-116-8-630.
- Marx JJ Jr, Twiggs JT, Ault BJ, Merchant JA, Fernandez-Caldas E. Inhaled aeroallergen and storage mite reactivity in a Wisconsin farmer nested case-control study. Am Rev Respir Dis. 1993 Feb;147(2):354-8. doi: 10.1164/ajrccm/147.2.354.
研究记录日期
研究主要日期
学习开始
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- 2009
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