Understanding the Genetic Basis of Atherosclerosis and Peripheral Arterial Disease (GenePAD)
The Genetic Determinants of Peripheral Arterial Disease
研究概览
地位
条件
详细说明
Plaque build-up caused by atherosclerosis increases the risk of blood clots, heart attack, and stroke. Blockages of plaque can occur in different areas of the body. PAD, a circulatory disorder in which blockages occur in the peripheral arteries, is one manifestation of atherosclerosis. Individuals with PAD experience reduced blood flow to the legs, which may cause leg pain while walking. Coronary artery disease (CAD), in which plaque builds up in arteries leading to the heart, is another atherosclerosis-related condition. Individuals with PAD and CAD have similar atherosclerosis risk factors, but it remains unknown why some individuals develop one disease and not the other. Genetic differences may influence where atherosclerosis develops. The goal of the study is to identify genetic variations that may cause inherited differences in plaque distribution.
This study will enroll individuals with PAD who have been referred by their doctor for a coronary angiogram to confirm the presence of CAD. A control group composed of individuals who do not have PAD, but have similar risk factors for atherosclerosis, will also be enrolled. All participants will attend one study visit. They will undergo a coronary angiogram, a procedure in which a special dye is inserted intravenously into an artery of the heart. X-rays will be taken to document how blood flows through the artery. Questionnaires assessing quality of life, exercise habits, tobacco exposure, and family medical history will be completed. Participants will also undergo blood pressure measurements and blood collection for genetic analysis. Yearly follow-up phone calls will occur for 5 years to document any hospitalizations.
研究类型
注册 (实际的)
联系人和位置
学习地点
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California
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Stanford、California、美国、94305
- Stanford University
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New York
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New York、New York、美国、10029
- Mt. Sinai Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Hemodynamically significant PAD, as documented by an ankle-brachial index less than 0.9; control group participants will not have PAD
- Received a referral for an elective coronary angiogram
- Suspected CAD
Exclusion Criteria:
- History of radiation treatment
- History of organ transplant
- History of viral diseases (i.e. HIV, hepatitis)
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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1
Subjects with no hemodynamically significant disease (NHSD) of the coronary or peripheral arteries
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2
Subjects with coronary artery disease only
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3
Subjects with both coronary artery disease and peripheral arterial disease
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
Identifying genetic variations that may cause inherited differences in plaque distribution
大体时间:Measured at participants' study visit
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Measured at participants' study visit
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合作者和调查者
调查人员
- 首席研究员:John P. Cooke, MD, PhD、Stanford University
出版物和有用的链接
一般刊物
- Flores AM, Schuler A, Eberhard AV, Olin JW, Cooke JP, Leeper NJ, Shah NH, Ross EG. Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups. J Am Heart Assoc. 2021 Dec 7;10(23):e021976. doi: 10.1161/JAHA.121.021976. Epub 2021 Nov 30.
- Sadrzadeh Rafie AH, Stefanick ML, Sims ST, Phan T, Higgins M, Gabriel A, Assimes T, Narasimhan B, Nead KT, Myers J, Olin J, Cooke JP. Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization. Vasc Med. 2010 Dec;15(6):443-50. doi: 10.1177/1358863X10388345.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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