Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell Disease (ETENDARD)
Evaluation of the Characteristics, Prevalence and Prognosis of Pulmonary Hypertension in Adult Patients With Sickle Cell Disease: Study ETENDARD.
研究概览
地位
条件
详细说明
Consecutive adult patients with sickle cell disease (SCD) had a Doppler echocardiography to evaluate if they had a suspected pulmonary hypertension (PH) on the basis of a tricuspid regurgitation jet (TRJ) velocity > or equal at 2.5m/s. In this case, a right heart catheterization was performed to confirm or not this diagnosis and its mechanisms. Each included patient was followed every year for 3 years: during each visit, a clinical evaluation was obtained and a Doppler echocardiography. In case of emergence of a suspected PH, a right heart catheterization was performed to confirm or not this diagnosis and its mechanisms.
Three groups of patients were defined: no PH, precapillary PH, and a third group including post-capillary PH and hyperkinetic state. These groups were well defined on the basis of the results of th Doppler echocardiography and right heart catheterisation.
Characteristics of patients and their prognosis were evaluated in each group.
In the same, way, biological study is planned to evaluate some biological markers of the mechanism of PH, and prognostic factors.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Clamart、法国、92141
- Hôpital Antoine Béclère
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Homozygous SS sickle cell disease
- Male or female > 18 years of age
- VOC (Vaso-Occlusive crisis) or ACS (Acute chest syndrome)within 6 weeks of inclusion ("Stable state")
- Signed written Informed consent
Exclusion Criteria:
- Creatinine clearance < 30 ml/mn
- prothrombin ratio < 50%
- Severe pneumopathy and TLC (Total lung capacity) < 70%
学习计划
研究是如何设计的？
设计细节
合作者和调查者
调查人员
- 首席研究员：Gerald SIMONNEAU, MD、Hopital Antoine Béclère, CLAMART
- 首席研究员：Frederic Galacteros, MD、Hopital Henri Mondor, Creteil
- 研究主任：Serge ADNOT, MD、Hopital Henri Mondor, Creteil
- 研究主任：Bernard MAITRE, MD、Hopital Henri Mondor, Creteil
- 研究主任：Marc HUMBERT, MD、Hopital Antoine Béclère, CLAMART
- 研究主任：Robert GIROT, MD、Hôpital TENON, PARIS
- 研究主任：François LIONNET, MD、Hôpital TENON, PARIS
- 研究主任：Françoise DRISS, MD、Hôpital Bicêtre, KREMLIN BICETRE
- 学习椅：Olivier LAMBOTTE, MD、Hôpital Bicêtre, KREMLIN BICETRE
- 研究主任：Jocelyn INAMO, MD、CHU Fort de France
- 研究主任：Gylna LOKO, MD、CHU Fort de France
- 研究主任：Olivier SITBON, MD、Hopital Antoine Béclère, CLAMART
- 研究主任：Xavier Jaïs, MD、Hopital Antoine Béclère, CLAMART
- 学习椅：Anoosha Habibi, MD、Hopital Henri Mondor, Creteil
- 学习椅：Dora Bachir, MD、Hopital Henri Mondor, Creteil
- 学习椅：Laurent SAVALE, MD、Hopital Henri Mondor, Creteil
- 学习椅：Saadia Eddahibi, MD、Hopital Henri Mondor, Creteil
- 学习椅：Gilles Garcia, MD、Hopital Antoine Béclère, CLAMART
出版物和有用的链接
一般刊物
- Rubin LJ, Badesch DB, Barst RJ, Galie N, Black CM, Keogh A, Pulido T, Frost A, Roux S, Leconte I, Landzberg M, Simonneau G. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med. 2002 Mar 21;346(12):896-903. doi: 10.1056/NEJMoa012212. Erratum In: N Engl J Med 2002 Apr 18;346(16):1258.
- Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med. 2004 Sep 30;351(14):1425-36. doi: 10.1056/NEJMra040291. No abstract available.
- Simonneau G, Galie N, Rubin LJ, Langleben D, Seeger W, Domenighetti G, Gibbs S, Lebrec D, Speich R, Beghetti M, Rich S, Fishman A. Clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):5S-12S. doi: 10.1016/j.jacc.2004.02.037.
- Lechapt E, Habibi A, Bachir D, Galacteros F, Schaeffer A, Desvaux D, Brochard L, Housset B, Godeau B, Maitre B. Induced sputum versus bronchoalveolar lavage during acute chest syndrome in sickle cell disease. Am J Respir Crit Care Med. 2003 Dec 1;168(11):1373-7. doi: 10.1164/rccm.200302-174OC. Epub 2003 Sep 11.
- Maitre B, Habibi A, Roudot-Thoraval F, Bachir D, Belghiti DD, Galacteros F, Godeau B. Acute chest syndrome in adults with sickle cell disease. Chest. 2000 May;117(5):1386-92. doi: 10.1378/chest.117.5.1386.
- Parent F, Bachir D, Inamo J, Lionnet F, Driss F, Loko G, Habibi A, Bennani S, Savale L, Adnot S, Maitre B, Yaici A, Hajji L, O'Callaghan DS, Clerson P, Girot R, Galacteros F, Simonneau G. A hemodynamic study of pulmonary hypertension in sickle cell disease. N Engl J Med. 2011 Jul 7;365(1):44-53. doi: 10.1056/NEJMoa1005565.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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