Integrated Multidisciplinary Care for Parkinson's Disease: a Controlled Trial
研究概览
详细说明
PD is a complex disorder, with motor as well as non-motor symptoms. Despite the complexity of PD, management of the disease is often 'monodisciplinary' since most patients are only treated by a neurologist. Stimulating compensatory strategies by allied health professionals might offer additional therapeutic relief, but this assumption is mainly based on theoretical arguments and expert opinion. Even less is known about the claim that a multidisciplinary team of multiple professionals active in complementary domains (e.g. physiotherapy, occupational therapy and speech therapy) is superior to management by each of these professionals alone.
This study anticipates to provide more insight in the clinical effectiveness and health care costs of multidisciplinary treatment in PD. Therefore, our multidisciplinary care concept (a comprehensive assessment by a dedicated multidisciplinary team and subsequent treatment by specifically trained health professionals) that is tailored to the patients' individual needs will be compared to usual care in terms of effectiveness and costs.
研究类型
注册 (实际的)
阶段
- 第三阶段
联系人和位置
学习地点
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Almelo、荷兰
- Ziekenhuis Groep Twente, Twenteborg Ziekenhuis
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Arnhem、荷兰
- Ziekenhuis Rijnstate
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Assen、荷兰
- Wilhelmina Ziekenhuis Assen
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Hengelo、荷兰
- Ziekenhuis Groep Twente, Streekziekenhuis Midden-Twente
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Leeuwarden、荷兰
- Medisch Centrum Leeuwarden
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Nijmegen、荷兰
- Canisius Wilhelmina Ziekenhuis
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Patients with Idiopathic PD, diagnosed according to the Brain Bank Criteria of the UK Parkinson's Disease Society
- Regular control by the neurologist
- Living independently in the community
- Able to complete the trial questionnaires
Exclusion Criteria:
- Atypical parkinsonian syndromes
- Hoehn and Yahr stage 5
- Severe cognitive impairment (MMSE<24)
- Presence of other neurological disorders
- Severe co-morbidity (e.g. cancer)
- Planned surgical procedure for PD within the intervention period
- Patients who have already visited the Multidisciplinary Assessment Center
学习计划
研究是如何设计的？
设计细节
- 主要用途：支持治疗
- 分配：非随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：I
Multidisciplinary Care
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A comprehensive individualised assessment by a dedicated multidisciplinary team (Multidisciplinary Assessment Center) and subsequent treatment by specifically trained health professionals (ParkinsonNet).
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其他：II
Usual Care
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No altered organisation of care
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Parkinson's Disease Quality of Life Questionnaire (PDQL)
大体时间：8 months
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8 months
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AMC Linear Disability Score (ALDS)
大体时间：8 months
|
8 months
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
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SF-36 (secundary;utility score)
大体时间：8 months
|
8 months
|
|
UPDRS Motor Examination (part III)(secondary)
大体时间：4 months
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4 months
|
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UPDRS Complications of therapy (part IV)(tertiary)
大体时间：4 months
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4 months
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SPDDS(tertiary)
大体时间：8 months
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8 months
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Modified MACTAR scale(tertiary)
大体时间：8 months
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8 months
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Parkinson Activity Scale(tertiary)
大体时间：4 months
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4 months
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成本（次要）
大体时间：8个月
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8个月
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Frequency of falls (tertiary)
大体时间：8 months
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8 months
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Freezing of Gait Questionnaire (tertiary)
大体时间：8 months
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8 months
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跌倒效能量表（三级）
大体时间：8个月
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8个月
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Non-Motor Symptom Assessment Scale and Quest for Parkinson's Disease (tertiary)
大体时间：8 months (Quest) and 4 months (Scale)
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8 months (Quest) and 4 months (Scale)
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Hospital Anxiety and Depression Scale (tertiary)
大体时间：8 months
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8 months
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Caregiver burden assessed with BELA-A-k (secondary), SF-36 (tertiary), and HADS (tertiary)
大体时间：8 months
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8 months
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合作者和调查者
调查人员
- 首席研究员：Marten Munneke, PhD、UMC St Radboud
- 首席研究员：Bastiaan R Bloem, MD, PhD、UMC St Radboud
- 首席研究员：Marjolein A van der Marck, MSc、UMC St Radboud
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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