Postoperative Pain Treatment in Total Hip Arthroplasty: A Study to Assess the Effect of Local Analgesia

Inclusion Criteria:

• Scheduled for an uncemented unilateral Total Hip Replacement because of osteoarthritis
• Willingness and possibility to follow the instructions of the study
• 18 years or older
• written informed consent and authority after it has been read and understood.

Exclusion Criteria:

• Operation with anterior approach or using navigation
• Do not understand or speech danish
• Can not use the pain-score Numerical Rating Scale (NRS)
• Special indications for Total Hip Replacement
• Anaesthetized in general anaesthesia where a tube is demanded
• Daily use of strong opioids, based on the investigators assessment
• Fertile women
• ASA-score: 3 and 4
• Known allergy against the standardized pain treatment, the study drugs and placebo, Ropivacaine, Ketorolac, Adrenalin.
• Treatment with Lithium, Dihydroergotamin, full anticoagulant treatment or MAO-inhibitor
• Following illness:
• Active gastric ulcer or earlier gastrointestinal bleeding, ulceration or perforation of any kind.
• Suspicions of manifest gastrointestinal bleeding and/or cerebrovascular bleeding
• Haemorrhagic diathesis
• Coagulation disorder
• Severe thrombocytopenia
• Severe heart insufficiency
• Severe risk of postoperative bleeding or delayed haemostatic
• Myocardium hypertrophy or ischaemic heart disease
• Hypertension
• Hypovolemics
• Anhydration
• angiooedema
• Asthma
• Bronchospasm
• Severe liver insufficiency
• Rhinostenosis because of polyostotic
• Narrow-angled glaucoma
• Phaeochromocytoma
• Low plasm-potassium
• Thyreotoxicosis