Evaluation of Toxic Metals, Trace Elements and Total Antioxidant Activity in Children With Recurrent Wheezing
Sectional Prospective Randomised Study of Evaluation Toxic Metals, Trace Elements Status and Total Antioxidant Activity in Children With Recurrent Wheezing.
研究概览
详细说明
Context:
In many studies it was demonstrated that children are much more susceptible than adults for environmental toxic metal exposure. Hair analysis is a promising tool for routine clinical screening and diagnosis of heavy metal exposure and essential trace element states in the human body. Additionally it was demonstrated that oxidants and antioxidants play a central role in the pathogenesis of many pulmonary diseases including asthma. Furthermore, toxic metals, trace elements and oxidative stress have many pivotal role on immune system.
Objective:
To evaluate and compare hair toxic metals, hair essential trace elements levels and plasma total antioxidant activity between children with recurrent wheezing and age and sex matched healthy children.
Intervention: Hair samples will be collected for the analysis of the toxic metals, trace elements. Blood samples will be collected for the analysis of the cytokine levels and plasma antioxidant activity.
Study Measures:
Differences in hair toxic metals, hair trace elements, plasma cytokine levels and plasma total antioxidant activity will be compared between children with recurrent wheezing and age-sex matched healthy children
研究类型
注册 (实际的)
联系人和位置
学习地点
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Kecioren
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Ankara、Kecioren、火鸡、06380
- Kecioren Eğitim Araştırma Hastanesi
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Children with recurrent wheezing ages between 6 months to 6 years old.
- Age and sex matched healthy children for control group.
- Parental/guardian permission (informed consent)
Exclusion Criteria:
- Systemic corticosteroid use in the last 30 days
- Chronic lung diseases including cystic fibrosis
- Immunodeficiency
- Known renal or hepatic dysfunction
- Respiratory truck infections in the last 30 days
- Anatomic abnormalities of the respiratory tract
- Suspected foreign body aspiration or croup
- Immunosuppressive or immunostimulant treatment
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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1
Children vith recurrent wheezing
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2
Healthy children
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
Hair toxic metal and trace element status in the two groups
大体时间:6 months
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6 months
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次要结果测量
结果测量 |
大体时间 |
---|---|
To compare plasma total antioxidant activity in the two groups.
大体时间:6 months
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6 months
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Effect of heavy metals and trace elements on plasma cytokine levels and difference between the two groups
大体时间:6 months
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6 months
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
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