Effects of 3 Months of Supervised Exercise Training
Effects of 3 Months of Supervised Exercise Training on Cardiometabolic and Inflammatory Biomarkers According to Glucose Tolerance (Normal, Intolerance and Type 2 Diabetes): Measures in Unstimulated and Stimulated Conditions
The incidence of type 2 diabetes is increasing worldwide. Because of cardiovascular morbidity and mortality associated with type 2 diabetes, it is imperative to propose methods of prevention and this in early stage of abnormal glucose metabolism.
This study will assess the beneficial effects of physical activity (acute and chronic effects) (the subjects being their own controls) on cardiometabolic and inflammatory biomarkers in 3 conditions : unstimulated (fasting and resting conditions) and stimulated conditions: postprandial response to a standardized meal preceded or not by an exercise bout.
The investigators hypothesized that an acute bout of exercise will decrease the postprandial inflammatory response to a standardized meal and that this effect of exercise will be increased after 3 months of exercise training.
研究概览
详细说明
This is a prospective study over 4 months, open, nonrandomized. 45 overweight or obese male subjects will complete 3 experimental sessions (0700-1400h) before and after 3 months of supervised physical training. During a first session, subjects will remain inactive and fasted (basal conditions). During the second session a standardized meal will be offered (postprandial response to a standardized meal). The third session will consist in the realization of an exercise bout (60min at 60%VO2 max) followed by a standardized meal (same meal that the previous day).
Several blood (catheter), salivary and urinary samples will be collected during the 3 sessions, throughout the experimental day.
研究类型
注册 (预期的)
阶段
- 不适用
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Male Caucasian Adults between 30 and 65 years old Sedentary criteria based on the determination of fasting glucose (WHO 1999):
- normal if fasting plasma glucose (FPG) <1.10 g / l
- diabetes if fasting glucose> 1.26 g / l (7 mmol / l) twice
- nondiabetic fasting hyperglycemia: 1.10 g / l ≤ FPG ≤ 1.26 g / l
- glucose intolerance : if plasma glucose at 120 minutes during the OGTT (75g) is between 1.40 g / l and 2 g/ l.
Body mass index 25 BMI 35kg/m2 Affiliated to National Health Insurance Subject giving his written informed consent Subject considered as normal after clinical examination and medical questionnaire
Exclusion Criteria:
- - drugs that interfere with the parameters determined
- diabetic treated with insulin, glitazones or glinides
- eating disorders like bulimia and vomiting
- special diet, vegan or vegetarian
- autoimmune disease or inflammatory progressive desease requiring prolonged treatment
- regular physical activity (> 1 hour of physical activity per week for at least 6 months)
- smoking (> 5 cigarettes / day)
- weight change greater than 5% of the total weight in the 3 months preceding the study
- contra-indication to physical activity
- chronic pathologies: cancer, inflammatory, cardiac, pulmonary, renal, gastrointestinal or liver diseases
- Being in exclusion on the National Volunteers Data file
- No one under guardianship or not subject to social security.
- Being under someone's supervision
- Subjects deprived of their liberty by judicial or administrative.
- Refusal to sign the information sheet and written consent for particip
学习计划
研究是如何设计的?
设计细节
- 主要用途:基础科学
- 分配:非随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
supervised physical training on cardiometabolic and inflammatory biomarkers
大体时间:after 3 months
|
after 3 months
|
次要结果测量
结果测量 |
大体时间 |
---|---|
relationships between cortisol secretion and the postprandial inflammatory responses depending on the level of glucose tolerance
大体时间:after 3 months
|
after 3 months
|
合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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