Effects of Different Coffee Amounts on Energy Intake, Appetite, Glucose Metabolism and Inflammatory Markers
2011年12月19日 更新者:M. Yannakoulia、Harokopio University
The Effect of Different Amounts of Coffee on Dietary Intake, Appetite-related Feeling, Appetite Hormones, Glucose Metabolism and Inflammatory Markers of Normal Weight and Overweight/Obese Individuals
The purpose of the study is to investigate whether different doses of caffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and glucose metabolism compared to water consumption in normal weight and overweight/obese participants.
研究概览
研究类型
介入性
注册 (实际的)
33
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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Athens、希腊、17671
- Metabolic Unit of the Department of Nutrition and Dietetics, Harokopio University
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 45年 (成人)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria:
- apparently healthy
- habitual coffee drinkers (>= 1cup of coffee/day)
Exclusion Criteria:
- smokers
- restrained eaters (as this was evaluated using the Dutch Eating Behaviour Questionnaire)
- those who reported slimming or any other dietary regime
- athletes
- participants with a known diagnosis of either hypertension, diabetes, impaired glucose tolerance or a fasting blood glucose concentration above 125 mg/dl
- subjects on medication for hypertension or on medication known to alter glucose metabolism
- subjects who were on medication that may have an impact on appetite and sensory functioning or who reported a metabolic or
- endocrine disease,
- gastrointestinal disorders,
- a history of medical or surgical events that may have affected the study outcomes
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:随机化
- 介入模型:交叉作业
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的:coffee3
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Comparison of different amounts of coffee
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实验性的:coffee6
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Comparison of different amounts of coffee
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安慰剂比较:water
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Comparison of different amounts of coffee
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
energy intake ad libitum
大体时间:180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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total energy intake
大体时间:One day
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One day
|
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appetite feelings
大体时间:fasting (-15 min)
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fasting (-15 min)
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appetite feelings
大体时间:immediately after breakfast/drink consumption (0 min)
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immediately after breakfast/drink consumption (0 min)
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appetite feelings
大体时间:15 min after breakfast/drink consumption
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15 min after breakfast/drink consumption
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appetite feelings
大体时间:30 min after breakfast/drink consumption
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30 min after breakfast/drink consumption
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appetite feelings
大体时间:60 min after breakfast/drink consumption
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60 min after breakfast/drink consumption
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appetite feelings
大体时间:90 min after breakfast/drink consumption
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90 min after breakfast/drink consumption
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appetite feelings
大体时间:120 min after breakfast/drink consumption
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120 min after breakfast/drink consumption
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appetite feelings
大体时间:150 min after breakfast/drink consumption
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150 min after breakfast/drink consumption
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|
appetite feelings
大体时间:180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
|
|
appetite hormones
大体时间:fasting (-15 min)
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fasting (-15 min)
|
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appetite hormones
大体时间:immediately after breakfast/drink consumption (0 min)
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immediately after breakfast/drink consumption (0 min)
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appetite hormones
大体时间:15 min after breakfast/drink consumption
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15 min after breakfast/drink consumption
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appetite hormones
大体时间:30 min after breakfast/drink consumption
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30 min after breakfast/drink consumption
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appetite hormones
大体时间:60 min after breakfast/drink consumption
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60 min after breakfast/drink consumption
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appetite hormones
大体时间:90 min after breakfast/drink consumption
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90 min after breakfast/drink consumption
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appetite hormones
大体时间:120 min after breakfast/drink consumption
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120 min after breakfast/drink consumption
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appetite hormones
大体时间:150 min after breakfast/drink consumption
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150 min after breakfast/drink consumption
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appetite hormones
大体时间:180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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markers of inflammation
大体时间:fasting (-15 min)
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fasting (-15 min)
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markers of inflammation
大体时间:immediately after breakfast/drink consumption (0 min)
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immediately after breakfast/drink consumption (0 min)
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markers of inflammation
大体时间:15 min after breakfast/drink consumption
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15 min after breakfast/drink consumption
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markers of inflammation
大体时间:30 min after breakfast/drink consumption
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30 min after breakfast/drink consumption
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markers of inflammation
大体时间:60 min after breakfast/drink consumption
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60 min after breakfast/drink consumption
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markers of inflammation
大体时间:90 min after breakfast/drink consumption
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90 min after breakfast/drink consumption
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markers of inflammation
大体时间:120 min after breakfast/drink consumption
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120 min after breakfast/drink consumption
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markers of inflammation
大体时间:150 min after breakfast/drink consumption
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150 min after breakfast/drink consumption
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markers of inflammation
大体时间:180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
|
|
markers of glucose metabolism
大体时间:fasting (-15 min)
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fasting (-15 min)
|
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markers of glucose metabolism
大体时间:immediately after breakfast/drink consumption (0 min)
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immediately after breakfast/drink consumption (0 min)
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markers of glucose metabolism
大体时间:15 min after breakfast/drink consumption
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15 min after breakfast/drink consumption
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markers of glucose metabolism
大体时间:30 min after breakfast/drink consumption
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30 min after breakfast/drink consumption
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markers of glucose metabolism
大体时间:60 min after breakfast/drink consumption
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60 min after breakfast/drink consumption
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markers of glucose metabolism
大体时间:90 min after breakfast/drink consumption
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90 min after breakfast/drink consumption
|
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markers of glucose metabolism
大体时间:120 min after breakfast/drink consumption
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120 min after breakfast/drink consumption
|
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markers of glucose metabolism
大体时间:150 min after breakfast/drink consumption
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150 min after breakfast/drink consumption
|
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markers of glucose metabolism
大体时间:180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
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% carbohydrates ad libitum
大体时间:180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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% carbohydrates total day
大体时间:One day
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One day
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% protein ad libitum
大体时间:180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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% protein total day
大体时间:One day
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One day
|
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% fat
大体时间:180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
|
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% fat total day
大体时间:One day
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One day
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员:Mary Yannakoulia, PhD、Harokopio University
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Perakakis N, Kokkinos A, Angelidi AM, Tsilingiris D, Gavrieli A, Yannakoulia M, Tentolouris N, Mantzoros CS. Circulating levels of five proglucagon-derived peptides in response to intravenous or oral glucose or lipids and to a mixed-meal in subjects with normal weight, overweight, and obesity. Clin Nutr. 2022 Sep;41(9):1969-1976. doi: 10.1016/j.clnu.2022.07.001. Epub 2022 Jul 19.
- Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7. doi: 10.3945/jn.110.137323. Epub 2011 Feb 23.
- Gavrieli A, Fragopoulou E, Mantzoros CS, Yannakoulia M. Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial. Metabolism. 2013 Aug;62(8):1099-106. doi: 10.1016/j.metabol.2013.02.003. Epub 2013 Mar 15.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2011年1月1日
初级完成 (实际的)
2011年6月1日
研究完成 (实际的)
2011年6月1日
研究注册日期
首次提交
2011年12月16日
首先提交符合 QC 标准的
2011年12月19日
首次发布 (估计)
2011年12月20日
研究记录更新
最后更新发布 (估计)
2011年12月20日
上次提交的符合 QC 标准的更新
2011年12月19日
最后验证
2011年12月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.