Effects of Different Coffee Amounts on Energy Intake, Appetite, Glucose Metabolism and Inflammatory Markers
19. december 2011 opdateret af: M. Yannakoulia, Harokopio University
The Effect of Different Amounts of Coffee on Dietary Intake, Appetite-related Feeling, Appetite Hormones, Glucose Metabolism and Inflammatory Markers of Normal Weight and Overweight/Obese Individuals
The purpose of the study is to investigate whether different doses of caffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and glucose metabolism compared to water consumption in normal weight and overweight/obese participants.
Studieoversigt
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
33
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Athens, Grækenland, 17671
- Metabolic Unit of the Department of Nutrition and Dietetics, Harokopio University
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 45 år (Voksen)
Tager imod sunde frivillige
Ja
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- apparently healthy
- habitual coffee drinkers (>= 1cup of coffee/day)
Exclusion Criteria:
- smokers
- restrained eaters (as this was evaluated using the Dutch Eating Behaviour Questionnaire)
- those who reported slimming or any other dietary regime
- athletes
- participants with a known diagnosis of either hypertension, diabetes, impaired glucose tolerance or a fasting blood glucose concentration above 125 mg/dl
- subjects on medication for hypertension or on medication known to alter glucose metabolism
- subjects who were on medication that may have an impact on appetite and sensory functioning or who reported a metabolic or
- endocrine disease,
- gastrointestinal disorders,
- a history of medical or surgical events that may have affected the study outcomes
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Crossover opgave
- Maskning: Enkelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
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Eksperimentel: coffee3
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Comparison of different amounts of coffee
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Eksperimentel: coffee6
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Comparison of different amounts of coffee
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Placebo komparator: water
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Comparison of different amounts of coffee
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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energy intake ad libitum
Tidsramme: 180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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total energy intake
Tidsramme: One day
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One day
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appetite feelings
Tidsramme: fasting (-15 min)
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fasting (-15 min)
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appetite feelings
Tidsramme: immediately after breakfast/drink consumption (0 min)
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immediately after breakfast/drink consumption (0 min)
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|
appetite feelings
Tidsramme: 15 min after breakfast/drink consumption
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15 min after breakfast/drink consumption
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appetite feelings
Tidsramme: 30 min after breakfast/drink consumption
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30 min after breakfast/drink consumption
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appetite feelings
Tidsramme: 60 min after breakfast/drink consumption
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60 min after breakfast/drink consumption
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appetite feelings
Tidsramme: 90 min after breakfast/drink consumption
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90 min after breakfast/drink consumption
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appetite feelings
Tidsramme: 120 min after breakfast/drink consumption
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120 min after breakfast/drink consumption
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appetite feelings
Tidsramme: 150 min after breakfast/drink consumption
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150 min after breakfast/drink consumption
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appetite feelings
Tidsramme: 180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
|
|
appetite hormones
Tidsramme: fasting (-15 min)
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fasting (-15 min)
|
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appetite hormones
Tidsramme: immediately after breakfast/drink consumption (0 min)
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immediately after breakfast/drink consumption (0 min)
|
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appetite hormones
Tidsramme: 15 min after breakfast/drink consumption
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15 min after breakfast/drink consumption
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appetite hormones
Tidsramme: 30 min after breakfast/drink consumption
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30 min after breakfast/drink consumption
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appetite hormones
Tidsramme: 60 min after breakfast/drink consumption
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60 min after breakfast/drink consumption
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appetite hormones
Tidsramme: 90 min after breakfast/drink consumption
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90 min after breakfast/drink consumption
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appetite hormones
Tidsramme: 120 min after breakfast/drink consumption
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120 min after breakfast/drink consumption
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appetite hormones
Tidsramme: 150 min after breakfast/drink consumption
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150 min after breakfast/drink consumption
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appetite hormones
Tidsramme: 180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
|
|
markers of inflammation
Tidsramme: fasting (-15 min)
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fasting (-15 min)
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markers of inflammation
Tidsramme: immediately after breakfast/drink consumption (0 min)
|
immediately after breakfast/drink consumption (0 min)
|
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markers of inflammation
Tidsramme: 15 min after breakfast/drink consumption
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15 min after breakfast/drink consumption
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markers of inflammation
Tidsramme: 30 min after breakfast/drink consumption
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30 min after breakfast/drink consumption
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markers of inflammation
Tidsramme: 60 min after breakfast/drink consumption
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60 min after breakfast/drink consumption
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markers of inflammation
Tidsramme: 90 min after breakfast/drink consumption
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90 min after breakfast/drink consumption
|
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markers of inflammation
Tidsramme: 120 min after breakfast/drink consumption
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120 min after breakfast/drink consumption
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markers of inflammation
Tidsramme: 150 min after breakfast/drink consumption
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150 min after breakfast/drink consumption
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markers of inflammation
Tidsramme: 180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
|
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markers of glucose metabolism
Tidsramme: fasting (-15 min)
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fasting (-15 min)
|
|
markers of glucose metabolism
Tidsramme: immediately after breakfast/drink consumption (0 min)
|
immediately after breakfast/drink consumption (0 min)
|
|
markers of glucose metabolism
Tidsramme: 15 min after breakfast/drink consumption
|
15 min after breakfast/drink consumption
|
|
markers of glucose metabolism
Tidsramme: 30 min after breakfast/drink consumption
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30 min after breakfast/drink consumption
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markers of glucose metabolism
Tidsramme: 60 min after breakfast/drink consumption
|
60 min after breakfast/drink consumption
|
|
markers of glucose metabolism
Tidsramme: 90 min after breakfast/drink consumption
|
90 min after breakfast/drink consumption
|
|
markers of glucose metabolism
Tidsramme: 120 min after breakfast/drink consumption
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120 min after breakfast/drink consumption
|
|
markers of glucose metabolism
Tidsramme: 150 min after breakfast/drink consumption
|
150 min after breakfast/drink consumption
|
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markers of glucose metabolism
Tidsramme: 180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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% carbohydrates ad libitum
Tidsramme: 180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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% carbohydrates total day
Tidsramme: One day
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One day
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% protein ad libitum
Tidsramme: 180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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% protein total day
Tidsramme: One day
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One day
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% fat
Tidsramme: 180 min after breakfast/drink consumption
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180 min after breakfast/drink consumption
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% fat total day
Tidsramme: One day
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One day
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Mary Yannakoulia, PhD, Harokopio University
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Perakakis N, Kokkinos A, Angelidi AM, Tsilingiris D, Gavrieli A, Yannakoulia M, Tentolouris N, Mantzoros CS. Circulating levels of five proglucagon-derived peptides in response to intravenous or oral glucose or lipids and to a mixed-meal in subjects with normal weight, overweight, and obesity. Clin Nutr. 2022 Sep;41(9):1969-1976. doi: 10.1016/j.clnu.2022.07.001. Epub 2022 Jul 19.
- Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7. doi: 10.3945/jn.110.137323. Epub 2011 Feb 23.
- Gavrieli A, Fragopoulou E, Mantzoros CS, Yannakoulia M. Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial. Metabolism. 2013 Aug;62(8):1099-106. doi: 10.1016/j.metabol.2013.02.003. Epub 2013 Mar 15.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. januar 2011
Primær færdiggørelse (Faktiske)
1. juni 2011
Studieafslutning (Faktiske)
1. juni 2011
Datoer for studieregistrering
Først indsendt
16. december 2011
Først indsendt, der opfyldte QC-kriterier
19. december 2011
Først opslået (Skøn)
20. december 2011
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
20. december 2011
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
19. december 2011
Sidst verificeret
1. december 2011
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- CofSt3
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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