Effects of Different Coffee Amounts on Energy Intake, Appetite, Glucose Metabolism and Inflammatory Markers

The Effect of Different Amounts of Coffee on Dietary Intake, Appetite-related Feeling, Appetite Hormones, Glucose Metabolism and Inflammatory Markers of Normal Weight and Overweight/Obese Individuals

The purpose of the study is to investigate whether different doses of caffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and glucose metabolism compared to water consumption in normal weight and overweight/obese participants.

Study Overview

• Status: Completed
• Conditions: Inflammation; Obesity
• Intervention / Treatment: Other: coffee

• Study Type: Interventional
• Enrollment (Actual): 33
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Greece
  • Athens, Greece, 17671
    • Metabolic Unit of the Department of Nutrition and Dietetics, Harokopio University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• apparently healthy
• habitual coffee drinkers (>= 1cup of coffee/day)

Exclusion Criteria:

• smokers
• restrained eaters (as this was evaluated using the Dutch Eating Behaviour Questionnaire)
• those who reported slimming or any other dietary regime
• athletes
• participants with a known diagnosis of either hypertension, diabetes, impaired glucose tolerance or a fasting blood glucose concentration above 125 mg/dl
• subjects on medication for hypertension or on medication known to alter glucose metabolism
• subjects who were on medication that may have an impact on appetite and sensory functioning or who reported a metabolic or
• endocrine disease,
• gastrointestinal disorders,
• a history of medical or surgical events that may have affected the study outcomes

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: coffee3	Other: coffee; Comparison of different amounts of coffee
Experimental: coffee6	Other: coffee; Comparison of different amounts of coffee
Placebo Comparator: water	Other: coffee; Comparison of different amounts of coffee

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
energy intake ad libitum	180 min after breakfast/drink consumption
total energy intake	One day
appetite feelings	fasting (-15 min)
appetite feelings	immediately after breakfast/drink consumption (0 min)
appetite feelings	15 min after breakfast/drink consumption
appetite feelings	30 min after breakfast/drink consumption
appetite feelings	60 min after breakfast/drink consumption
appetite feelings	90 min after breakfast/drink consumption
appetite feelings	120 min after breakfast/drink consumption
appetite feelings	150 min after breakfast/drink consumption
appetite feelings	180 min after breakfast/drink consumption
appetite hormones	fasting (-15 min)
appetite hormones	immediately after breakfast/drink consumption (0 min)
appetite hormones	15 min after breakfast/drink consumption
appetite hormones	30 min after breakfast/drink consumption
appetite hormones	60 min after breakfast/drink consumption
appetite hormones	90 min after breakfast/drink consumption
appetite hormones	120 min after breakfast/drink consumption
appetite hormones	150 min after breakfast/drink consumption
appetite hormones	180 min after breakfast/drink consumption
markers of inflammation	fasting (-15 min)
markers of inflammation	immediately after breakfast/drink consumption (0 min)
markers of inflammation	15 min after breakfast/drink consumption
markers of inflammation	30 min after breakfast/drink consumption
markers of inflammation	60 min after breakfast/drink consumption
markers of inflammation	90 min after breakfast/drink consumption
markers of inflammation	120 min after breakfast/drink consumption
markers of inflammation	150 min after breakfast/drink consumption
markers of inflammation	180 min after breakfast/drink consumption
markers of glucose metabolism	fasting (-15 min)
markers of glucose metabolism	immediately after breakfast/drink consumption (0 min)
markers of glucose metabolism	15 min after breakfast/drink consumption
markers of glucose metabolism	30 min after breakfast/drink consumption
markers of glucose metabolism	60 min after breakfast/drink consumption
markers of glucose metabolism	90 min after breakfast/drink consumption
markers of glucose metabolism	120 min after breakfast/drink consumption
markers of glucose metabolism	150 min after breakfast/drink consumption
markers of glucose metabolism	180 min after breakfast/drink consumption

Secondary Outcome Measures

Outcome Measure	Time Frame
% carbohydrates ad libitum	180 min after breakfast/drink consumption
% carbohydrates total day	One day
% protein ad libitum	180 min after breakfast/drink consumption
% protein total day	One day
% fat	180 min after breakfast/drink consumption
% fat total day	One day

Collaborators and Investigators

• Sponsor: Harokopio University
• Investigators: Principal Investigator: Mary Yannakoulia, PhD, Harokopio University

Publications and helpful links

General Publications

• Perakakis N, Kokkinos A, Angelidi AM, Tsilingiris D, Gavrieli A, Yannakoulia M, Tentolouris N, Mantzoros CS. Circulating levels of five proglucagon-derived peptides in response to intravenous or oral glucose or lipids and to a mixed-meal in subjects with normal weight, overweight, and obesity. Clin Nutr. 2022 Sep;41(9):1969-1976. doi: 10.1016/j.clnu.2022.07.001. Epub 2022 Jul 19.
• Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7. doi: 10.3945/jn.110.137323. Epub 2011 Feb 23.
• Gavrieli A, Fragopoulou E, Mantzoros CS, Yannakoulia M. Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial. Metabolism. 2013 Aug;62(8):1099-106. doi: 10.1016/j.metabol.2013.02.003. Epub 2013 Mar 15.

Study record dates

Study Major Dates

• Study Start: January 1, 2011
• Primary Completion (Actual): June 1, 2011
• Study Completion (Actual): June 1, 2011

Study Registration Dates

• First Submitted: December 16, 2011
• First Submitted That Met QC Criteria: December 19, 2011
• First Posted (Estimate): December 20, 2011

Study Record Updates

• Last Update Posted (Estimate): December 20, 2011
• Last Update Submitted That Met QC Criteria: December 19, 2011
• Last Verified: December 1, 2011

More Information

Terms related to this study

• Keywords: randomized controlled trial; appetite; energy intake; inflammation; coffee; glucose metabolism; overweight/obese
• Additional Relevant MeSH Terms: Pathologic Processes; Inflammation
• Other Study ID Numbers: CofSt3