The Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients
the Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients
Abdominal aortic aneurysm (AAA) is a common disease that develops from degeneration of the aortic wall. The natural history of AAA is gradual expansion and if left untreated may result in rupture and death. The mechanism of the development of this disease is unknown however it appears to be multifactorial and possibly related to degradation processes within the arterial wall. There is growing evidence that Angiotensin receptor blockers ( ARBS) may have an inhibitory effect on remodelling processes within the arterial wall, thus inhibiting degeneration of the vessel wall.
Study hypothesis: ARBS are associated with smaller diameters of aortas among hypertensive patients, and are associated with a lower rate of aortic expansion compared to other antihypertensive drugs.
研究概览
研究类型
注册 (预期的)
联系人和位置
学习地点
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Tel Hashomer、以色列
- 招聘中
- Sheba Medical Center
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接触:
- Daniel Silverberg, MD
- 邮箱:Daniel.Silverberg@sheba.health.gov.il
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- medically treated hypertensive patients, ages 50-80
Exclusion Criteria:
- pregnant women
- patients previously treated for aortic disease
- unable to sign informed consent, minors
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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ARBs
Hypertensive patients treated with ARBs
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ACE inhibitors
Hypertensive patients treated with ACE inhibitors
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non ARB/ACE
Hypertensive patients treated with non ARBs or ACE inhibitors meds
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合作者和调查者
调查人员
- 首席研究员:Daniel Silverberg, MD、Sheba Medical Center
研究记录日期
研究主要日期
学习开始
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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