Early Markers of Alzheimer's Disease: Structural and Functional Brain Changes
Early Markers of Alzheimer's Disease in BLSA Participants: Structural and Functional Brain Changes
Background:
- Participants in the Baltimore Longitudinal Study of Aging are being studied to examine changes in brain structure and function over time, and to determine if these changes can predict the likelihood that an individual will develop thinking and memory impairments such as Alzheimer s disease later in life. Imaging studies and neuropsychological testing have been conducted on current participants, and new participants are being recruited to the study. To develop better treatments and therapies for aging-related memory loss and other disorders, researchers are interested in determining whether early prediction of thinking and memory impairments are accurate and in evaluating factors that affect these predictions.
Objectives:
- To use imaging studies and tests of thinking and memory to determine early markers of Alzheimer s disease and other cognitive impairments.
Eligibility:
- Current participants and new recruits to the Baltimore Longitudinal Study of Aging.
Design:
- Participants will be screened with a full medical history and physical examination, as well as blood and urine tests.
- Participants will have testing visits as directed by the study researchers. All participants will have tests as part of their an initial enrollment in the study, and may be asked to return yearly, 2 years later, or 4 years later for repeated tests.
- At each visit, participants will have brain imaging scans (including magnetic resonance imaging and/or magnetic resonance spectroscopy to measure brain structure and function, and positron emission tomography to study blood flow in the brain) to evaluate brain structure and function. Participants will also take tests of memory and problem-solving skills.
- Treatment will not be provided as part of this protocol.
研究概览
地位
条件
详细说明
研究类型
注册 (实际的)
联系人和位置
学习地点
-
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Maryland
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Baltimore、Maryland、美国、21205
- Johns Hopkins University
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Baltimore、Maryland、美国、21205
- Kennedy Krieger Institute
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Baltimore、Maryland、美国、21224
- National Institute of Aging, Clinical Research Unit
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
- INCLUSION CRITERIA:
BLSA participants who do not meet exclusion criteria
EXCLUSION CRITERIA:
- Miscellaneous: Body weight > 300 pounds, history of significant radiation exposure.
- Participants with pacemakers, implanted electronic hearing devices, aneurysm clips, shrapnel, unallowed prosthetic or any other metallic device in their bodies.
- Pre-existing CNS disease or severe cardiovascular disease (MI, CABG, angioplasty).
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
Accelerated preclinical changes in brain structure and function in specific regions will predict which individuals develop cognitive impairment and Alzheimer s disease
大体时间:Ongoing
|
Ongoing
|
Changes in brain structure are predictors of cognitive decline and impairment though neuroimaging assessments
大体时间:Ongoing
|
Ongoing
|
合作者和调查者
调查人员
- 首席研究员:Susan M Resnick, Ph.D.、National Institute on Aging (NIA)
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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