- ICH GCP
- Registro degli studi clinici negli Stati Uniti
- Sperimentazione clinica NCT01867372
Early Markers of Alzheimer's Disease: Structural and Functional Brain Changes
Early Markers of Alzheimer's Disease in BLSA Participants: Structural and Functional Brain Changes
Background:
- Participants in the Baltimore Longitudinal Study of Aging are being studied to examine changes in brain structure and function over time, and to determine if these changes can predict the likelihood that an individual will develop thinking and memory impairments such as Alzheimer s disease later in life. Imaging studies and neuropsychological testing have been conducted on current participants, and new participants are being recruited to the study. To develop better treatments and therapies for aging-related memory loss and other disorders, researchers are interested in determining whether early prediction of thinking and memory impairments are accurate and in evaluating factors that affect these predictions.
Objectives:
- To use imaging studies and tests of thinking and memory to determine early markers of Alzheimer s disease and other cognitive impairments.
Eligibility:
- Current participants and new recruits to the Baltimore Longitudinal Study of Aging.
Design:
- Participants will be screened with a full medical history and physical examination, as well as blood and urine tests.
- Participants will have testing visits as directed by the study researchers. All participants will have tests as part of their an initial enrollment in the study, and may be asked to return yearly, 2 years later, or 4 years later for repeated tests.
- At each visit, participants will have brain imaging scans (including magnetic resonance imaging and/or magnetic resonance spectroscopy to measure brain structure and function, and positron emission tomography to study blood flow in the brain) to evaluate brain structure and function. Participants will also take tests of memory and problem-solving skills.
- Treatment will not be provided as part of this protocol.
Panoramica dello studio
Stato
Condizioni
Descrizione dettagliata
Tipo di studio
Iscrizione (Effettivo)
Contatti e Sedi
Luoghi di studio
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Maryland
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Baltimore, Maryland, Stati Uniti, 21205
- Johns Hopkins University
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Baltimore, Maryland, Stati Uniti, 21205
- Kennedy Krieger Institute
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Baltimore, Maryland, Stati Uniti, 21224
- National Institute of Aging, Clinical Research Unit
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Criteri di partecipazione
Criteri di ammissibilità
Età idonea allo studio
Accetta volontari sani
Sessi ammissibili allo studio
Descrizione
- INCLUSION CRITERIA:
BLSA participants who do not meet exclusion criteria
EXCLUSION CRITERIA:
- Miscellaneous: Body weight > 300 pounds, history of significant radiation exposure.
- Participants with pacemakers, implanted electronic hearing devices, aneurysm clips, shrapnel, unallowed prosthetic or any other metallic device in their bodies.
- Pre-existing CNS disease or severe cardiovascular disease (MI, CABG, angioplasty).
Piano di studio
Come è strutturato lo studio?
Dettagli di progettazione
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Lasso di tempo |
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Accelerated preclinical changes in brain structure and function in specific regions will predict which individuals develop cognitive impairment and Alzheimer s disease
Lasso di tempo: Ongoing
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Ongoing
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Changes in brain structure are predictors of cognitive decline and impairment though neuroimaging assessments
Lasso di tempo: Ongoing
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Ongoing
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Collaboratori e investigatori
Collaboratori
Investigatori
- Investigatore principale: Susan M Resnick, Ph.D., National Institute on Aging (NIA)
Studiare le date dei record
Studia le date principali
Inizio studio
Completamento primario (Effettivo)
Completamento dello studio
Date di iscrizione allo studio
Primo inviato
Primo inviato che soddisfa i criteri di controllo qualità
Primo Inserito (Stima)
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo verificato
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- 999903328
- 03-AG-N328
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .