Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment
2026年4月29日 更新者：Helen Lavretsky, MD、University of California, Los Angeles
The purpose of this pilot study is to test whether 6 months of supervised weekly Kundalini yoga classes and a brief daily meditation homework assignment can improve memory and thinking in older adults with mild memory complaints when compared to weekly classes of memory training with daily homework assignments.
研究概览
详细说明
The purpose of this pilot study intervention is to investigate brain mechanisms of response to memory enhancement training (MET) compared to Kundalini yoga and "Kirtan Kriya" meditation using functional magnetic resonance imaging (fMRI) that will be acquired from each subject at baseline and at 12 weeks (post-randomization).
Overall, the investigators anticipate recruiting 66 adults with memory complaints and diagnosed with MCI for adults 55 years old and older. Subjects will either receive: (1) MET class for 60 minutes per week; or (2) Kundalini yoga and "Kirtan Kriya" meditation class for 60 minutes per week. All assessments will be completed immediately after the interventions for a total of 10 visits in 12 weeks and a follow-up visit at 6 months (24 weeks)to monitor the overall benefit of the intervention.
研究类型
介入性
注册 (实际的)
81
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
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California
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Los Angeles、California、美国、90095
- UCLA Semel Institute
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
55年 至 90年 (成人、年长者)
接受健康志愿者
不
描述
Inclusion Criteria:
- Mild cognitive impairment amnestic type
- Clinical Dementia Rating scale score of 0.5
- SufficientEnglish proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV
- Capacity to provide informed consent.
Exclusion criteria:
- Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
- Any disabilities preventing their participation in the memory enhancement training (MET) (e.g. severe visual or hearing impairment)
- Insufficient English proficiency
- Diagnosis of dementia
- Mini Mental Health Examination score of 24 and below
- Psychoactive medications
- Participation in a psychotherapy that involves cognitive training
- Do not meet criteria for Mild cognitive impairment subtype
- Prior or current training in yoga.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：支持治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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有源比较器：记忆训练
将针对遗忘性轻度认知障碍 (MCI) 进行团体记忆训练
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参与者将参加为期 12 周的每周记忆训练课程，并在 12 周内接受每日记忆作业（持续时间为 12 分钟）。
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实验性的：Kundalini yoga and meditation
Participants will engage in weekly yoga classes and daily 20 minute meditation
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参与者将每周参加 60 分钟的瑜伽和冥想课程，持续 12 周，并将每天分配 Kirtan Kriya 冥想（持续 12 分钟），持续 12 周。
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Cognitive Measures - Hopkins Verbal Learning Test (HVLT) Total Recall Score
大体时间：At baseline and at 6 months
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Primary outcome measures were administered by a cognitive battery of neuropsychological and included memory and executive functioning.
Verbal memory was measured with the Hopkins Verbal Learning Test (HVLT) total recall scores.
The HVLT form contains 12 nouns, four words each from one of three semantic categories (e.g., precious gems, articles of clothing, vegetables, etc.), to be learned over the course of three learning trials.
When scoring the HVLT, the three learning trials are combined to calculate a total recall score.
Total scores range from 0-36 with higher scores indicating better outcome.
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At baseline and at 6 months
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Clinical Global Impression Scale
大体时间：Baseline, weeks 2, 4, 6, 8, 10, 12, 24
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The CGI measures severity of illness and global improvement.
The CGI is rated on a 7-point scale, with the severity of illness scale using a range of responses from 1 (normal) through to 7 (amongst the most severely ill patients).
CGI global improvement scores range from 1 (very much improved) through to 7 (very much worse).
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Baseline, weeks 2, 4, 6, 8, 10, 12, 24
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Geriatric Depression Scale (GDS)
大体时间：Baseline and Week 24
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Secondary outcomes measures included mood assessments with the GDS, a self-assessment scale often used in geriatric depression trials.
The GDS is a 30-item screening tool used to identify depression in older adults.
In scoring the Geriatric Depression Scale, each item is scored 0 or 1.
The total score on the scale ranges from 0 to 30 with higher scores indicating worse outcome.
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Baseline and Week 24
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Change in Functional Magnetic Resonance Imaging (fMRI) Connectivity
大体时间：Baseline and week 12
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FMRI scans will be obtained at baseline and after 12 weeks follow up.
Default mode network findings were analyzed and significant effects were identified for yoga and memory enhancement training groups.
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Baseline and week 12
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：Helen Lavretsky, MD, MS、UCLA Semel Institute
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2013年9月1日
初级完成 (实际的)
2016年5月1日
研究完成 (实际的)
2016年5月1日
研究注册日期
首次提交
2013年10月30日
首先提交符合 QC 标准的
2013年11月7日
首次发布 (估计的)
2013年11月14日
研究记录更新
最后更新发布 (实际的)
2026年5月22日
上次提交的符合 QC 标准的更新
2026年4月29日
最后验证
2026年4月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.