S. Aureus Colonization in Atopic Dermatitis
Staphylococcus Aureus Colonization in Atopic Dermatitis
The purpose of this study is to characterize the bacterial strains that colonize children with atopic dermatitis.
The investigators hypothesize that rectal cultures will be more sensitive than anterior nares cultures for detecting S. aureus colonization, and that strains of S. aureus colonizing patients with atopic dermatitis will be resistant to commonly used topical antibiotic ointments.
研究概览
地位
条件
详细说明
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritis and eczematous lesions with a worldwide prevalence of 15-20%. The burden of disease is highest in the most developed nations and predominantly affects children, with 50% of cases arising in the first year of life, and most others arising in the first 5 years. There is a well-known increased susceptibility to skin infection with S. aureus in patients with AD, and such infections are associated with clinical deterioration. While it is routine to evaluate for S. aureus colonization in the anterior nares, there is recent evidence suggesting that rectal colonization may be more significant. The significance of colonization site has not been evaluated in the AD population.
Additionally, while topical antibiotics are a mainstay of treatment in AD, there is no routine data on the resistance to these agents.
Our aim is to characterize the S. aureus colonization patterns in children with AD, including site of colonization and antibiotic resistance. We will analyze routinely-collected skin culture specimens from children with AD seen at our center and determine antibiotic susceptibility profiles. The significance of colonization site will be analyzed.
研究类型
注册 (预期的)
联系人和位置
学习地点
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New York
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New York、New York、美国、10032
- Columbia University Medical Center / Department of Dermatology
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- subjects with a diagnosis of atopic dermatitis seen by the Columbia University Medical Center department of dermatology
- subjects ages 0 to 18 years
Exclusion Criteria:
- those patients in which a definitive diagnosis of AD cannot be made
- subjects over the age of 18 years old
- subjects with evidence of acute systemic illness
- subjects currently taking systemic antibiotics
- subjects with viral or fungal skin infection
- any individual who declines participation
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Difference in rectal and nasal S. aureus colonization rates in a population of children with atopic dermatitis
大体时间：Up to 3 years
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Up to 3 years
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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Rates of resistance to commonly used topical antibiotic ointments in strains of S. aureus that colonize a population of children with atopic dermatitis
大体时间：Up to 20 years
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Up to 20 years
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合作者和调查者
调查人员
- 首席研究员：Christine T Lauren, MD、Columbia University
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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