Primed vs Unprimed Facilitatory and Depressive Paired Associative Stimulation
Following brain injury (e.g. stroke), application of non-invasive brain stimulation may improve rehabilitative efforts. However, the most effective method of non-invasive brain stimulation is unknown. Paired associative stimulation (PAS) is a method of non-invasive brain stimulation that pairs an electrical peripheral nerve stimulus with a magnetic stimulus to the head. This method can be applied in a manner that increases (facilitates) or decreases (depresses) excitability within the brain. Furthermore, applying two consecutive PAS sessions within minutes of each other (called primed PAS) may augment changes in excitability more than a single PAS session alone.
Thus, the purpose of this study is to compare the effect of a double PAS session (primed PAS) to the effect of a single PAS session (unprimed PAS) and a sham PAS session in healthy individuals.
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- ≥ 18 and ≤ 30 years of age
- Elicitable motor evoked potential from the motor cortex contralateral to the dominant hand
- Elicitable N20 sensory evoked potential
Exclusion Criteria:
- History of neurological disease
- Seizure within the past 2 years
- Currently taking epileptogenic medication
- Peripheral neuropathy
- Cognitive impairment and/or major psychiatric disorder
- Metal in the head (dental permitted)
- Pacemaker or other indwelling devices
- Pregnancy
学习计划
研究是如何设计的？
设计细节
- 主要用途：设备可行性
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Primed PAS 1A
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
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其他名称：
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实验性的：Unprimed PAS 1B
A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.
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其他名称：
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假比较器：Sham PAS
A single session of sham paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied
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其他名称：
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实验性的：Primed PAS 2A
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
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其他名称：
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实验性的：Unprimed PAS 2B
A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.
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其他名称：
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实验性的：Primed PAS 1C
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
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其他名称：
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实验性的：Primed PAS 2C
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
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其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change from baseline peak-to-peak amplitude of motor evoked potential
大体时间：Immediately before and within 60 minutes following intervention
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Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG).
The peak-to-peak amplitude of the EMG response will be measured.
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Immediately before and within 60 minutes following intervention
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Change from baseline resting motor threshold
大体时间：Immediately before and within 60 minutes following intervention
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Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG).
The lowest stimulator output needed to elicit a consistent response will be recorded.
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Immediately before and within 60 minutes following intervention
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合作者和调查者
调查人员
- 首席研究员：Kate Frost, MS、University of Minnesota
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 1601M82561
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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