Primed vs Unprimed Facilitatory and Depressive Paired Associative Stimulation
Following brain injury (e.g. stroke), application of non-invasive brain stimulation may improve rehabilitative efforts. However, the most effective method of non-invasive brain stimulation is unknown. Paired associative stimulation (PAS) is a method of non-invasive brain stimulation that pairs an electrical peripheral nerve stimulus with a magnetic stimulus to the head. This method can be applied in a manner that increases (facilitates) or decreases (depresses) excitability within the brain. Furthermore, applying two consecutive PAS sessions within minutes of each other (called primed PAS) may augment changes in excitability more than a single PAS session alone.
Thus, the purpose of this study is to compare the effect of a double PAS session (primed PAS) to the effect of a single PAS session (unprimed PAS) and a sham PAS session in healthy individuals.
Studieöversikt
Status
Betingelser
Intervention / Behandling
Studietyp
Inskrivning (Faktisk)
Fas
- Inte tillämpbar
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Beskrivning
Inclusion Criteria:
- ≥ 18 and ≤ 30 years of age
- Elicitable motor evoked potential from the motor cortex contralateral to the dominant hand
- Elicitable N20 sensory evoked potential
Exclusion Criteria:
- History of neurological disease
- Seizure within the past 2 years
- Currently taking epileptogenic medication
- Peripheral neuropathy
- Cognitive impairment and/or major psychiatric disorder
- Metal in the head (dental permitted)
- Pacemaker or other indwelling devices
- Pregnancy
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Enhetens genomförbarhet
- Tilldelning: Randomiserad
- Interventionsmodell: Crossover tilldelning
- Maskning: Dubbel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: Primed PAS 1A
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
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Andra namn:
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Experimentell: Unprimed PAS 1B
A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.
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Andra namn:
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Sham Comparator: Sham PAS
A single session of sham paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied
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Andra namn:
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Experimentell: Primed PAS 2A
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
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Andra namn:
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Experimentell: Unprimed PAS 2B
A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.
|
Andra namn:
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Experimentell: Primed PAS 1C
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
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Andra namn:
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Experimentell: Primed PAS 2C
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
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Andra namn:
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Change from baseline peak-to-peak amplitude of motor evoked potential
Tidsram: Immediately before and within 60 minutes following intervention
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Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG).
The peak-to-peak amplitude of the EMG response will be measured.
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Immediately before and within 60 minutes following intervention
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Change from baseline resting motor threshold
Tidsram: Immediately before and within 60 minutes following intervention
|
Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG).
The lowest stimulator output needed to elicit a consistent response will be recorded.
|
Immediately before and within 60 minutes following intervention
|
Samarbetspartners och utredare
Sponsor
Utredare
- Huvudutredare: Kate Frost, MS, University of Minnesota
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Faktisk)
Avslutad studie (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Andra studie-ID-nummer
- 1601M82561
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