Risk Factors and Prediction Score of ARDS After Cardiac Surgery
2021年1月28日 更新者:Guangfa Zhu、Beijing Anzhen Hospital
Acute respiratory distress syndrome following cardiac surgery severely affects the prognosis of patients; the mortality is up to 40%.
Although experience many years of research and exploration, the effective methods for the treatment of acute respiratory distress syndrome is still relatively limited at present, including lung protective mechanical ventilation respiratory support, fluid management, glucocorticoid and other integrated organ function maintenance measures.
It is currently the research of acute respiratory distress syndrome aims at the early discovery and takes effective measures to prevent its occurrence, hoping to improve the prognosis of patients.
According to risk factors is established through the analysis of lung injury score early warning system, the early identification of acute respiratory distress syndrome patients at high risk, before the occurrence of acute respiratory distress syndrome take corresponding preventive measures can effectively reduce the incidence rate and mortality.
So far, domestic and foreign research on the establishment of acute respiratory distress syndrome scoring early warning system is less.
Cardiac surgery has significant characteristics, type of operation, location, operation, intraoperative blood transfusion and oxygenation, postoperative factors, are likely to be the factors of acute respiratory distress syndrome.
As far as investigators know, so far there are few specialized for acute respiratory distress syndrome predicting lung injury after cardiac surgery.
This study will be completed after the implementation of individualized dynamic lung injury score evaluation of cardiac surgery patients, identification of high-risk acute respiratory distress syndrome patients, to assist clinicians in early decision, take preventive measures.
This study will improve the prognosis of acute respiratory distress syndrome patients after cardiac surgery; it is of great significance to improve the level of intensive care after cardiac surgery.
研究概览
研究类型
观察性的
注册 (实际的)
1333
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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Beijing
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Beijing、Beijing、中国、100029
- Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
不
有资格学习的性别
全部
取样方法
非概率样本
研究人群
Patients of cardiac surgery in Beijing Anzhen hospital
描述
Inclusion Criteria:
- Retrospective group: cardiac surgery patients accepted from Jan 2013 to Dec 2015
- Prospective group: cardiac surgery patients accepted from 2017 January to December
Exclusion Criteria:
- refused to participate in the study
- age less than 18 years old
- before operation performed mechanical ventilation
- before operation underwent IABP treatment
- before operation continuous renal replacement therapy
- before operation undergoing in vitro membrane oxygenator treatment
- before operation has the pulmonary imaging showed bilateral pulmonary diffuse exudation of interstitial pneumonia, pulmonary infection or respiratory failure
- the major trauma, sepsis, aspiration, shock, acute heart failure
- before operation diagnosed as malignant tumor
- Incomplete data.
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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ARDS
ARDS patients after cardiac surgery
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This is a clinical observational study, no intervention was included.
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non-ARDS
non-ARDS patients after cardiac surgery
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This is a clinical observational study, no intervention was included.
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propective group
patients of cardiac surgery including ARDS and non-ARDS patients
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This is a clinical observational study, no intervention was included.
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
大体时间:up to 12months
|
up to 12months
|
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The number of patients of cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
大体时间:up to 12months
|
up to 12months
|
|
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
大体时间:up to 12months
|
up to 12months
|
|
The number of patients of cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
大体时间:up to 12months
|
up to 12months
|
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The number of diabetic patients in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
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The number of diabetic patients in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
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The number of chronic obstructive pulmonary disease patients in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
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The number of chronic obstructive pulmonary disease patients in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The type of operation in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The type of operation in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The body mass index in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The body mass index in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The heart function in ARDS group before operation.
大体时间:up to 1 month
|
up to 1 month
|
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The heart function in non-ARDS group before operation.
大体时间:up to 1 month
|
up to 1 month
|
|
The oxygenation in ARDS group before operation.
大体时间:up to 1 month
|
up to 1 month
|
|
The oxygenation in non-ARDS group before operation.
大体时间:up to 1 month
|
up to 1 month
|
|
The drug taken by patients in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The drug taken by patients in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The nutrition situation of patients in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The nutrition situation of patients in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The process of operation in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The process of operation in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The blood transfusion of patients during operation in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The blood transfusion of patients during operation in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The oxygenation of patients during operation in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The oxygenation of patients during operation in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The drug taken by patients after operation in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The drug taken by patients after operation in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The oxygenation of patients after operation in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The oxygenation of patients after operation in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The situation of mechanical ventilation of patients after operation in ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
|
The situation of mechanical ventilation of patients after operation in non-ARDS group.
大体时间:up to 1 month
|
up to 1 month
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
The mortality of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
大体时间:up to 1months
|
up to 1months
|
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The morbidity of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
大体时间:up to 1months
|
up to 1months
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 学习椅:Guangfa Zhu、Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- ARDS Definition Task Force; Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012 Jun 20;307(23):2526-33. doi: 10.1001/jama.2012.5669.
- Kogan A, Preisman S, Levin S, Raanani E, Sternik L. Adult respiratory distress syndrome following cardiac surgery. J Card Surg. 2014 Jan;29(1):41-6. doi: 10.1111/jocs.12264. Epub 2013 Dec 3.
- Berg KS, Stenseth R, Pleym H, Wahba A, Videm V. Mortality risk prediction in cardiac surgery: comparing a novel model with the EuroSCORE. Acta Anaesthesiol Scand. 2011 Mar;55(3):313-21. doi: 10.1111/j.1399-6576.2010.02393.x.
- Forel JM, Voillet F, Pulina D, Gacouin A, Perrin G, Barrau K, Jaber S, Arnal JM, Fathallah M, Auquier P, Roch A, Azoulay E, Papazian L. Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy. Crit Care. 2012 Dec 12;16(2):R65. doi: 10.1186/cc11312.
- Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR 3rd, Morris AH; National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med. 2015 Feb;43(2):288-95. doi: 10.1097/CCM.0000000000000715.
- Festic E, Kor DJ, Gajic O. Prevention of acute respiratory distress syndrome. Curr Opin Crit Care. 2015 Feb;21(1):82-90. doi: 10.1097/MCC.0000000000000174.
- Rubenfeld GD. Who cares about preventing acute respiratory distress syndrome? Am J Respir Crit Care Med. 2015 Feb 1;191(3):255-60. doi: 10.1164/rccm.201408-1574CP.
- Beitler JR, Schoenfeld DA, Thompson BT. Preventing ARDS: progress, promise, and pitfalls. Chest. 2014 Oct;146(4):1102-1113. doi: 10.1378/chest.14-0555.
- Milot J, Perron J, Lacasse Y, Letourneau L, Cartier PC, Maltais F. Incidence and predictors of ARDS after cardiac surgery. Chest. 2001 Mar;119(3):884-8. doi: 10.1378/chest.119.3.884.
- Michalopoulos A, Prapas S, Falagas ME. The incidence of adult respiratory distress syndrome in patients undergoing off-pump coronary artery bypass grafting surgery. Eur J Anaesthesiol. 2006 Jan;23(1):80. doi: 10.1017/S0265021505211821. No abstract available.
- Vakili M, Shirani S, Paknejad O, Yousefshahi F. Acute Respiratory Distress Syndrome diagnosis after coronary artery bypass: comparison between diagnostic criteria and clinical picture. Acta Med Iran. 2015;53(1):51-6.
- Kor DJ, Lingineni RK, Gajic O, Park PK, Blum JM, Hou PC, Hoth JJ, Anderson HL 3rd, Bajwa EK, Bartz RR, Adesanya A, Festic E, Gong MN, Carter RE, Talmor DS. Predicting risk of postoperative lung injury in high-risk surgical patients: a multicenter cohort study. Anesthesiology. 2014 May;120(5):1168-81. doi: 10.1097/ALN.0000000000000216.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2017年7月1日
初级完成 (实际的)
2017年9月30日
研究完成 (实际的)
2017年9月30日
研究注册日期
首次提交
2016年4月25日
首先提交符合 QC 标准的
2016年4月29日
首次发布 (估计)
2016年5月3日
研究记录更新
最后更新发布 (实际的)
2021年2月1日
上次提交的符合 QC 标准的更新
2021年1月28日
最后验证
2019年12月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.