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Risk Factors and Prediction Score of ARDS After Cardiac Surgery

2021年1月28日 更新者:Guangfa Zhu、Beijing Anzhen Hospital
Acute respiratory distress syndrome following cardiac surgery severely affects the prognosis of patients; the mortality is up to 40%. Although experience many years of research and exploration, the effective methods for the treatment of acute respiratory distress syndrome is still relatively limited at present, including lung protective mechanical ventilation respiratory support, fluid management, glucocorticoid and other integrated organ function maintenance measures. It is currently the research of acute respiratory distress syndrome aims at the early discovery and takes effective measures to prevent its occurrence, hoping to improve the prognosis of patients. According to risk factors is established through the analysis of lung injury score early warning system, the early identification of acute respiratory distress syndrome patients at high risk, before the occurrence of acute respiratory distress syndrome take corresponding preventive measures can effectively reduce the incidence rate and mortality. So far, domestic and foreign research on the establishment of acute respiratory distress syndrome scoring early warning system is less. Cardiac surgery has significant characteristics, type of operation, location, operation, intraoperative blood transfusion and oxygenation, postoperative factors, are likely to be the factors of acute respiratory distress syndrome. As far as investigators know, so far there are few specialized for acute respiratory distress syndrome predicting lung injury after cardiac surgery. This study will be completed after the implementation of individualized dynamic lung injury score evaluation of cardiac surgery patients, identification of high-risk acute respiratory distress syndrome patients, to assist clinicians in early decision, take preventive measures. This study will improve the prognosis of acute respiratory distress syndrome patients after cardiac surgery; it is of great significance to improve the level of intensive care after cardiac surgery.

研究概览

研究类型

观察性的

注册 (实际的)

1333

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习地点

    • Beijing
      • Beijing、Beijing、中国、100029
        • Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 孩子
  • 成人
  • 年长者

接受健康志愿者

有资格学习的性别

全部

取样方法

非概率样本

研究人群

Patients of cardiac surgery in Beijing Anzhen hospital

描述

Inclusion Criteria:

  • Retrospective group: cardiac surgery patients accepted from Jan 2013 to Dec 2015
  • Prospective group: cardiac surgery patients accepted from 2017 January to December

Exclusion Criteria:

  • refused to participate in the study
  • age less than 18 years old
  • before operation performed mechanical ventilation
  • before operation underwent IABP treatment
  • before operation continuous renal replacement therapy
  • before operation undergoing in vitro membrane oxygenator treatment
  • before operation has the pulmonary imaging showed bilateral pulmonary diffuse exudation of interstitial pneumonia, pulmonary infection or respiratory failure
  • the major trauma, sepsis, aspiration, shock, acute heart failure
  • before operation diagnosed as malignant tumor
  • Incomplete data.

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

队列和干预

团体/队列
干预/治疗
ARDS
ARDS patients after cardiac surgery
This is a clinical observational study, no intervention was included.
non-ARDS
non-ARDS patients after cardiac surgery
This is a clinical observational study, no intervention was included.
propective group
patients of cardiac surgery including ARDS and non-ARDS patients
This is a clinical observational study, no intervention was included.

研究衡量的是什么?

主要结果指标

结果测量
大体时间
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
大体时间:up to 12months
up to 12months
The number of patients of cardiac surgery in Anzhen hospital during Jan 2013 to Dec 2015.
大体时间:up to 12months
up to 12months
The number of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
大体时间:up to 12months
up to 12months
The number of patients of cardiac surgery in Anzhen hospital during Jan 2017 to Dec 2017.
大体时间:up to 12months
up to 12months
The number of diabetic patients in ARDS group.
大体时间:up to 1 month
up to 1 month
The number of diabetic patients in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The number of chronic obstructive pulmonary disease patients in ARDS group.
大体时间:up to 1 month
up to 1 month
The number of chronic obstructive pulmonary disease patients in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The type of operation in ARDS group.
大体时间:up to 1 month
up to 1 month
The type of operation in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The body mass index in ARDS group.
大体时间:up to 1 month
up to 1 month
The body mass index in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The heart function in ARDS group before operation.
大体时间:up to 1 month
up to 1 month
The heart function in non-ARDS group before operation.
大体时间:up to 1 month
up to 1 month
The oxygenation in ARDS group before operation.
大体时间:up to 1 month
up to 1 month
The oxygenation in non-ARDS group before operation.
大体时间:up to 1 month
up to 1 month
The drug taken by patients in ARDS group.
大体时间:up to 1 month
up to 1 month
The drug taken by patients in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The nutrition situation of patients in ARDS group.
大体时间:up to 1 month
up to 1 month
The nutrition situation of patients in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The process of operation in ARDS group.
大体时间:up to 1 month
up to 1 month
The process of operation in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The blood transfusion of patients during operation in ARDS group.
大体时间:up to 1 month
up to 1 month
The blood transfusion of patients during operation in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The oxygenation of patients during operation in ARDS group.
大体时间:up to 1 month
up to 1 month
The oxygenation of patients during operation in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The drug taken by patients after operation in ARDS group.
大体时间:up to 1 month
up to 1 month
The drug taken by patients after operation in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The oxygenation of patients after operation in ARDS group.
大体时间:up to 1 month
up to 1 month
The oxygenation of patients after operation in non-ARDS group.
大体时间:up to 1 month
up to 1 month
The situation of mechanical ventilation of patients after operation in ARDS group.
大体时间:up to 1 month
up to 1 month
The situation of mechanical ventilation of patients after operation in non-ARDS group.
大体时间:up to 1 month
up to 1 month

次要结果测量

结果测量
大体时间
The mortality of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
大体时间:up to 1months
up to 1months
The morbidity of acute respiratory distress syndrome following cardiac surgery in Anzhen hospital .
大体时间:up to 1months
up to 1months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

调查人员

  • 学习椅:Guangfa Zhu、Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2017年7月1日

初级完成 (实际的)

2017年9月30日

研究完成 (实际的)

2017年9月30日

研究注册日期

首次提交

2016年4月25日

首先提交符合 QC 标准的

2016年4月29日

首次发布 (估计)

2016年5月3日

研究记录更新

最后更新发布 (实际的)

2021年2月1日

上次提交的符合 QC 标准的更新

2021年1月28日

最后验证

2019年12月1日

更多信息

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

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